Results 161 to 170 of about 195,340 (251)

Neuronal CD59 isoforms IRIS-1 and IRIS-2 as regulators of neurotransmitter release with implications for Alzheimer's disease. [PDF]

Alzheimers Res Ther
Golec E, Olsson R, Tuysuz EC, Karlsson M, Serjieh Y, King BC, Wennström M, Blom AM.   +7 more
europepmc   +1 more source

A Selectfluor‐based Polonovski Rearrangement Leading to Novel Entities for Synthetic and Medicinal Applications

Chemistry – A European Journal, EarlyView.
Starting from carboxylic acids and Selectfluor‐derivatives, functionalized diazabicyclooctanes can be obtained via a novel Polonovski‐type rearrangement proceeding under mild reaction conditions. Besides their use in organic synthesis the unique structure and reactivity of the rearrangement products enables applications in medicinal chemistry ...
Jakob Kuhn, Susanne Gradl, Vanessa Osterloh, Peter Gmeiner, Harald Hübner, Markus R. Heinrich   +5 more
wiley   +1 more source

Correlation between evoked neurotransmitter release and adaptive functions in SYT1-associated neurodevelopmental disorder. [PDF]

EBioMedicine
Park PY, Bleakley LE, Saraya N, Al-Jawahiri R, Eck J, Aloi MA, Melland H, Baker K, Gordon SL.   +8 more
europepmc   +1 more source

How Amino Acids Intercalate in CaFe Layered Double Hydroxides: A Combined RIXS and NEXAFS Study

ChemPhysChem, Volume 26, Issue 6, March 15, 2025.
Intercalation of amino acids in layered double hydroxides offers a road to functional (bio)catalysts. With resonant soft x‐ray spectroscopy we probe the electronic structure of these systems and observe activation and passivation of electronic states as well as bond formation between the amino acid and the LDH upon intercalation.
R. Büchner, A. Born, K. Ruotsalainen, R. Decker, A. Pietzsch   +4 more
wiley   +1 more source

A high-performance GRAB sensor reveals differences in the dynamics and molecular regulation between neuropeptide and neurotransmitter release. [PDF]

Nat Commun
Xia X, Li Y.
europepmc   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

CB1R activates the epilepsy-associated protein Go to regulate neurotransmitter release and synaptic plasticity in the cerebellum. [PDF]

Proc Natl Acad Sci U S A
Choi JM, Acharya R, Cha HL, Lee KW, Seo J, Yang E, Kim H, Yoon JH, Chang DY, Kim SS, Kim SJ, Birnbaumer L, Suh-Kim H.   +12 more
europepmc   +1 more source

Advances in vital‐sign prediction and early‐warning models for underground coal mine workers integrating environmental factors

Deep Underground Science and Engineering, EarlyView.
This review synthesizes advances in predicting miners' vital signs by integrating environmental monitoring (dust, temperature, and gas) with physiological data. It highlights multi‐source data fusion techniques and early‐warning models for enhanced occupational safety in underground coal mines.
Junji Zhu, Dawei Cui, Yingjie Liu, Yuntao Liang, Yue Zhang   +4 more
wiley   +1 more source

The β integrin modulates serotonin sensitivity via NPxY motifs to regulate egg laying and mechanosensation behaviors in Caenorhabditis elegans

Developmental Dynamics, EarlyView.
Abstract Background Integrin is an αβ heterodimeric receptor to the extracellular matrix; its binding to the matrix recruits focal adhesions to two NPxY motifs, the tyrosine phosphorylation sites in the cytoplasmic domain. Studies found that replacing tyrosines (Y) with phenylalanines (F) in the motif of β1 integrin displayed little developmental or ...
Josh Haram Bumm, Daniel Dogeon Lee, Zhongqiang Qiu, Angela Haeun Choi, Meghana Kolluri, Michael J. Olsen, Lianzijun Wang, Myeongwoo Lee   +7 more
wiley   +1 more source

Applications of functional neurotransmitter release imaging with genetically encoded sensors in psychiatric research. [PDF]

Neuropsychopharmacology
Wright EC, Scott E, Tian L.
europepmc   +1 more source