Results 11 to 20 of about 12,876,613 (271)

Peripheral blood neurotrophic factor levels in children with autism spectrum disorder: a meta-analysis

Scientific Reports, 2021
Increasing evidence suggests that abnormal regulation of neurotrophic factors is involved in the etiology and pathogenesis of Autism Spectrum Disorder (ASD).
Shu-Han Liu, Xiao-Jie Shi, Fang-Cheng Fan, Yong Cheng   +3 more
doaj   +2 more sources

Unaltered low nerve growth factor and high brain-derived neurotrophic factor levels in plasma from patients with fibromyalgia after a 15-week progressive resistance exercise

Journal of Rehabilitation Medicine, 2019
Background: The pathophysiology of fibromyalgia includes central and peripheral factors. Neurotrophins, such as nerve growth factor and brain-derived neurotrophic factor, are involved in peripheral and central nervous system development of pain and ...
Anna Jablochkova, Emmanuel Bäckryd, Eva Kosek, Kaisa Mannerkorpi, Malin Ernberg, Björn Gerdle, Bijar Ghafouri   +6 more
doaj   +2 more sources

Brain-derived neurotrophic factor and mental disorders

Biomedical Journal, 2020
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in the brain, and is one of the most widely investigated molecule in psychiatric disorders.
Chin-Chuen Lin, Tiao-Lai Huang
doaj   +2 more sources

Brain-derived neurotrophic factor in Alzheimer’s disease and its pharmaceutical potential

Translational Neurodegeneration, 2022
Synaptic abnormalities are a cardinal feature of Alzheimer’s disease (AD) that are known to arise as the disease progresses. A growing body of evidence suggests that pathological alterations to neuronal circuits and synapses may provide a mechanistic ...
Li Gao, Yun Zhang, Keenan Sterling, Weihong Song   +3 more
semanticscholar   +1 more source

Recent Advances on the Role of Brain-Derived Neurotrophic Factor (BDNF) in Neurodegenerative Diseases

International Journal of Molecular Sciences, 2022
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are essential for neuronal survival and growth. The signaling cascades initiated by BDNF and its receptor are the key regulators of synaptic plasticity, which plays important role in ...
Khairunnuur Fairuz Azman, R. Zakaria
semanticscholar   +1 more source

Brain-Derived Neurotrophic Factor and Nerve Growth Factor Therapeutics for Brain Injury: The Current Translational Challenges in Preclinical and Clinical Research

Journal of Neural Transplantation and Plasticity, 2022
Ischemic stroke and traumatic brain injury (TBI) are among the leading causes of death and disability worldwide with impairments ranging from mild to severe.
Serena-Kaye Sims, Brynna Wilken-Resman, Crystal J Smith, Ashley Mitchell, Lilly McGonegal, Catrina Sims-Robinson   +5 more
semanticscholar   +1 more source

Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer

International Journal of Molecular Sciences, 2020
Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin receptor kinase B (TrkB) and the low affinity p75 neurotrophin receptor (p75NTR ...
L. Colucci-D'Amato, Luisa Speranza, Floriana Volpicelli   +2 more
semanticscholar   +1 more source

Brain-Derived Neurotrophic Factor and Diabetes

International Journal of Molecular Sciences, 2020
Diabetes and its chronic complications still represent a great clinical problem, despite improvements made in the diagnosis and treatment of the disease.
Olga Różańska, A. Uruska, D. Zozulinska-Ziolkiewicz   +2 more
semanticscholar   +1 more source

Caspase-2 is upregulated after sciatic nerve transection and its inhibition protects dorsal root ganglion neurons from Apoptosis after serum withdrawal [PDF]

, 2013
Sciatic nerve (SN) transection-induced apoptosis of dorsal root ganglion neurons (DRGN) is one factor determining the efficacy of peripheral axonal regeneration and the return of sensation.
A Madro, A McKay Hart, Alexandre Hiroaki Kihara, AM Hart, AM Vincent, Ann Logan, B Zhivotovsky, C Wetmore, CM Troy, CM Troy, CR Lin, D Chauvier, D Guseva, E Pannese, F Chen, G Jancso, G Terenghi, H Aldskogius, H Saito, H Vakifahmetoglu, IS Raginov, JX Tong, JX Tong, L Stefanis, LA O'Reilly, LH Ho, LJ Pagliari, M Hanani, M Lamkanfi, Martin Berry, MD Wood, PA Colussi, R Haviv, RU Janicke, S Kumar, S Kumar, S Tu, SS Arkhipova, T Gordon, V Schaeffer, Vasanthy Vigneswara, X Cao, XY Song, Z Ahmed, Z Ahmed, Z Ahmed, Z Ahmed, Z Gao, Zubair Ahmed   +48 more
core   +5 more sources

Ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons [PDF]

, 1989
Although evidence obtained with the PC12 cell line has suggested a role for the ras oncogene proteins in the signal transduction of nerve growth factor-mediated fiber outgrowth, little is known about the signal transduction mechanisms involved in the ...
Barde, Y. A., Borasio, Gian Domenico, Heumann, R., John, J., Sendtner, M., Wittinghofer, A.   +5 more
core   +2 more sources