Results 11 to 20 of about 4,508,815 (293)

The Adipose-Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte-Derived Neurotrophic Factor for WAT Browning. [PDF]

Adv Sci (Weinh)
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Jia XW, Liu JX, Wang RP, Wu XQ, Che Y, Wu MC, Shang HW, Lu X, Lu T, Wang LL, Jiang CY, Fang DL, Yang C, Gao Y.   +13 more
europepmc   +2 more sources

Mutant huntingtin impairs the post-Golgi trafficking of brain-derived neurotrophic factor but not its Val66Met polymorphism. [PDF]

, 2013
Brain-derived neurotrophic factor (BDNF) polymorphism is associated with the pathophysiology of several neurodegenerative disorders, including Huntington"s disease.
Toro Ruiz, Daniel del, Egea Guri, Gustavo, Ginés Padrós, Silvia, Kojima, Masami, Canals i Coll, Josep M., Alberch i Vié, Jordi, 1959-   +5 more
core   +1 more source

How does conserved dopamine neurotrophic factor protect against and rescue neurodegeneration of PC12 cells?

Neural Regeneration Research, 2017
Conserved dopamine neurotrophic factor protects and rescues dopaminergic neurodegeneration induced by 6-hydroxydopamine in vivo, but its potential value in treating Parkinson's disease remains controversial.
Jia-ming Mei, Chao-shi Niu
doaj   +1 more source

Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system [PDF]

, 2007
Support of ageing neurons by endogenous neurotrophic factors such as glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) may determine whether the neurons resist or succumb to neurodegeneration.
Aron, Liviu, Edgar R Kramer, Zhuang, Xiaoxi, Klein, R., Klaus Beyer, Geert M J Ramakers, Smidt, Marten P., Kramer, E., Ramakers, Geert M. J., Klein, Rüdiger, Beyer, K., Seitz, S., Marten P Smidt, Ramakers, G., Xiaoxi Zhuang, Beyer, Klaus, Zhuang, X., Liviu Aron, Sabine Seitz, Rüdiger Klein, Smidt, M., Seitz, Sabine, Kramer, Edgar R., Aron, L., Kramer Edgar R, Ramakers, Geert M. J, Smidt Marten P, Ramakers Geert M. J, Seitz Sabine, Aron Liviu, Zhuang Xiaoxi, Beyer Klaus, Klein Rüdiger   +32 more
core   +2 more sources

Acetyl-11-keto-beta-boswellic acid promotes sciatic nerve repair after injury: molecular mechanism

Neural Regeneration Research, 2022
Previous studies showed that acetyl-11-keto-beta-boswellic acid (AKBA), the active ingredient in the natural Chinese medicine Boswellia, can stimulate sciatic nerve injury repair via promoting Schwann cell proliferation. However, the underlying molecular
Yao Wang, Zong-Liang Xiong, Xiang-Lin Ma, Chong Zhou, Mo-Han Huo, Xiao-Wen Jiang, Wen-Hui Yu   +6 more
doaj   +1 more source

BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons [PDF]

, 2012
Although brain-derived neurotrophic factor (BDNF) regulates numerous and complex biological processes including memory retention, its extremely low levels in the mature central nervous system have greatly complicated attempts to reliably localize it ...
Ruben Deogracias, Barde, Yves-Alain, Masami Kojima, Dekkers, Martijn, Tomoya Matsumoto, Gundelfinger, Eckart D., Dieni, Sandra, Mihai S. Ionescu, Yves-Alain Barde, Deogracias, Ruben, Matsumoto, Tomoya, Sandra Dieni, Deogracias Pastor, Ruben, Rauskolb, Stefanie, Ionescu, Mihai S., Martijn Dekkers, Stefanie Rauskolb, Eckart D. Gundelfinger, Gundelfinger, Eckart D, Frotscher, Michael, Kojima, Masami, Nestel, Sigrun, Michael Frotscher, Sigrun Nestel, Barde, Yves Alain   +24 more
core   +1 more source

Randomized Trial of Ciliary Neurotrophic Factor Delivered by Encapsulated Cell Intraocular Implants for Retinitis Pigmentosa [PDF]

, 2013
PurposeTo evaluate the safety and effect on visual function of ciliary neurotrophic factor delivered via an intraocular encapsulated cell implant for the treatment of retinitis pigmentosa (RP).DesignCiliary neurotrophic factor for late-stage retinitis ...
Birch, David G, Tao, Weng, Groups, Ciliary Neurotrophic Factor Retinitis Pigmentosa Study, Weleber, Richard G, Duncan, Jacque L, Jaffe, Glenn J   +5 more
core   +1 more source

Antidepressant-like effects of trophic factor receptor signaling

Frontiers in Molecular Neuroscience, 2022
A significant body of research has demonstrated that antidepressants regulate neurotrophic factors and that neurotrophins themselves are capable of independently producing antidepressant-like effects.
Monica Sathyanesan, Monica Sathyanesan, Samuel S. Newton, Samuel S. Newton   +3 more
doaj   +1 more source

Long noncoding nature brain-derived neurotrophic factor antisense is associated with poor prognosis and functional regulation in non–small cell lung caner

Tumor Biology, 2017
In this study, we evaluated the prognostic potential and functional regulation of human nature antisense, brain-derived neurotrophic factor antisense, in non–small cell lung cancer.
MingJing Shen, Zhonghua Xu, Kanqiu Jiang, Weihua Xu, Yongbin Chen, ZhongHeng Xu   +5 more
doaj   +1 more source

Unaltered low nerve growth factor and high brain-derived neurotrophic factor levels in plasma from patients with fibromyalgia after a 15-week progressive resistance exercise

Journal of Rehabilitation Medicine, 2019
Background: The pathophysiology of fibromyalgia includes central and peripheral factors. Neurotrophins, such as nerve growth factor and brain-derived neurotrophic factor, are involved in peripheral and central nervous system development of pain and ...
Anna Jablochkova, Emmanuel Bäckryd, Eva Kosek, Kaisa Mannerkorpi, Malin Ernberg, Björn Gerdle, Bijar Ghafouri   +6 more
doaj   +1 more source