Results 31 to 40 of about 140,096 (282)

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

The effect of physical exercise on circulating brain‐derived neurotrophic factor in healthy subjects: A meta‐analysis of randomized controlled trials

Brain and Behavior, 2022
Objective To investigate how physical exercise (PE) would affect brain‐derived neurotrophic factor (BDNF) in randomized controlled trials (RCTs) of healthy subjects.
Ya‐Hai Wang, Huan‐Huan Zhou, Qiang Luo, Sidong Cui   +3 more
doaj   +1 more source

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source

Reduced Cortical Thicknesses of Adolescents with Bipolar Disorder and Relationship with Brain-derived Neurotrophic Factor

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, 2023
Cortical thickness (CT) and brain-derived neurotrophic factor (BDNF) were widely investigated in bipolar disorder (BD). Previous studies focused on the association between the volume of subcortical regions and neurotrophic factor levels.
İnal Neslihan, Cavusoglu Berrin, Ermiş Çağatay, Turan Serkan, Gormez Vahdet, Karabay Nuri   +5 more
doaj   +1 more source

Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Tyrosine kinase inhibitors are the cornerstone of chronic myeloid leukemia treatment. Newer agents have more potency and a broader spectrum of action, but also a higher potential for neuropsychiatric side effects. We present a case of a patient on imatinib who developed progressive cognitive, mood, and behavioral alterations.
Ashley Jones, Samuele Bonomi, Keith E. Stockerl‐Goldstein, Randall J. Bateman   +3 more
wiley   +1 more source

Neurotrophic Factors in Multiple Sclerosis: a Review of the Mechanism [PDF]

Neurology Letters
The objective of this review is to examine the mechanistic roles of neurotrophic factors (NTFs) in the pathology of multiple sclerosis (MS) and their potential as therapeutic agents. MS is a chronic autoimmune disease of the central nervous system (CNS),
Samaneh Azizpour, Vahid Moghadasi
doaj   +1 more source

Brain-derived neurotrophic factor and mental disorders

Biomedical Journal, 2020
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in the brain, and is one of the most widely investigated molecule in psychiatric disorders.
Chin-Chuen Lin, Tiao-Lai Huang
doaj   +1 more source

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

Brain region–specific roles of brain-derived neurotrophic factor in social stress–induced depressive-like behavior

Neural Regeneration Research
Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral response. Recent studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific ...
Man Han, Deyang Zeng, Wei Tan, Xingxing Chen, Shuyuan Bai, Qiong Wu, Yushan Chen, Zhen Wei, Yufei Mei, Yan Zeng   +9 more
doaj   +1 more source

Astrocyte‐Guided Maturation of Neural Constructs in a Modular Biosynthetic Hydrogel for Biohybrid Neurotechnologies

Advanced Functional Materials, EarlyView.
A modular biosynthetic PVA–gelatin hydrogel crosslinked via visible‐light thiol‐ene chemistry is engineered as a coating for neural electrodes. Optimizing matrix composition and mechanical properties enables the hydrogel to support astrocytic populations that guide neural differentiation and functional maturation.
Martina Genta, Sofia Peressotti, Roberto Portillo‐Lara, Josef Goding, Rylie Green   +4 more
wiley   +1 more source