Results 41 to 50 of about 12,815,513 (320)

Comparative Analysis of the Effects of Neurotrophic Factors CDNF and GDNF in a Nonhuman Primate Model of Parkinson’s Disease

PLoS ONE, 2016
Cerebral dopamine neurotrophic factor (CDNF) belongs to a newly discovered family of evolutionarily conserved neurotrophic factors. We demonstrate for the first time a therapeutic effect of CDNF in a unilateral 6-hydroxydopamine (6-OHDA) lesion model of ...
Enrique Garea-Rodriguez, A. Eesmaa, P. Lindholm, C. Schlumbohm, J. König, B. Meller, K. Krieglstein, G. Helms, M. Saarma, E. Fuchs   +9 more
semanticscholar   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Serum Brain-Derived Neurotrophic Factors in Taiwanese Patients with Drug-Naïve First-Episode Major Depressive Disorder: Effects of Antidepressants

International Journal of Neuropsychopharmacology, 2016
Background: Brain-derived neurotrophic factors are known to be related to the psychopathology of major depressive disorder. However, studies focusing on drug-naïve first-episode patients are still rare.
Yu‐Jie Chiou, Tiao-Lai Huang
semanticscholar   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

ELISA‐based quantification of neurotrophic growth factors in urine from prostate cancer patients

FASEB BioAdvances, 2021
Non‐invasive procedures are needed for prostate cancer management, and urine represents a potential source of new biomarkers with translational value. Recent evidence has shown that the growth of new nerves in the tumor microenvironment is essential to ...
Brayden March, Kathleen Rebecca Lockhart, Sam Faulkner, Markus Smolny, Robert Rush, Hubert Hondermarck   +5 more
doaj   +1 more source

Activation of signaling pathways following localized delivery of systemically administered neurotrophic factors across the blood–brain barrier using focused ultrasound and microbubbles

Physics in Medicine and Biology, 2012
Babak Baseri, James J. Choi, T. Deffieux, G. Samiotaki, Y. Tung, Oluyemi O. Olumolade, S. Small, B. Morrison, E. Konofagou   +8 more
semanticscholar   +3 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Peripheral biomarkers in bipolar disorder manic episode

Psychiatry and Behavioral Sciences, 2017
Bipolar disorder is a chronic illness of which the etiology is not fully elucidated. Recently, in order to understand the pathophysiogy of bipolar disorder, oxidative stress, inflammation, and neurotrophic factors have been widely studied. Although there
Abdullah Genc, Tevfik Kalelioğlu, Nesrin Karamustafalıoğlu   +2 more
doaj   +1 more source

Alzheimer’s Disease: Challenges and a Therapeutic Opportunity to Treat It with a Neurotrophic Compound

Biomolecules, 2022
Alzheimer’s disease (AD) is a progressive neurodegenerative disease with an insidious onset and multifactorial nature. A deficit in neurogenesis and synaptic plasticity are considered the early pathological features associated with neurofibrillary tau ...
Narjes Baazaoui, Khalid Iqbal
doaj   +1 more source

Delayed onset muscle soreness: Involvement of neurotrophic factors

Journal of Physiological Sciences, 2015
Delayed-onset muscle soreness (DOMS) is quite a common consequence of unaccustomed strenuous exercise, especially exercise containing eccentric contraction (lengthening contraction, LC).
K. Mizumura, T. Taguchi
semanticscholar   +1 more source