Results 91 to 100 of about 53,997 (300)

Neurotrophins in bronchial asthma [PDF]

Respiratory Research, 2001
Allergic bronchial asthma (BA) is characterized by chronic airway inflammation, development of airway hyperreactivity and recurrent reversible airway obstruction. T-helper 2 cells and their products have been shown to play an important role in this process.
openaire   +4 more sources

Toll-6 and Toll-7 function as neurotrophin receptors in the Drosophila central nervous system

Nature Neuroscience, 2013
Neurotrophin receptors corresponding to vertebrate Trk, p75NTR or Sortilin have not been identified in Drosophila, thus it is unknown how neurotrophism may be implemented in insects.
G. McIlroy, Istvan Foldi, Jukka P Aurikko, J. Wentzell, M. A. Lim, J. Fenton, N. Gay, A. Hidalgo   +7 more
semanticscholar   +1 more source

Effects of the VIVIFRAIL Exercise Protocol on Circulatory and Intracellular Peripheral Mediators Bridging Mitochondrial Dynamics and Inflammation in Robust and Frail Older People

Aging Cell, EarlyView.
Physical activity promotes functional improvements in both robust and physically frail older adults, driven by distinct adaptation mechanisms in the mitochondria‐inflammation axis that are influenced by age and frailty status. ABSTRACT Physical exercise has been associated with healthier aging trajectories, potentially preventing or mitigating age ...
Fiona Limanaqi, Evelyn Ferri, Pasquale Ogno, Franca Rosa Guerini, Gabriela Alexandra Mihali, Tiziano Lucchi, Mario Clerici, Chiara Fenoglio, Laura D'Andrea, Elena Marcello, Mara Biasin, Beatrice Arosio   +11 more
wiley   +1 more source

NT-4 Gene Expression of Male Wistar Rat’s Sciatic Nerve Fiber: The Effect of Decreased Activity on the Form of Spinal Nerve Ligation [PDF]

Journal of Advanced Biomedical Sciences, 2015
Background & Objectives: Painful neuropathy is a state resulting from somatosensory disease or injury. Neurotrophins such as NT-4 are crucial for neural growth and development and protect the integrity of function and structure of nervous system.
M Rahmati, A Kazemi, M Bagherian Rafsanjani, J Taherabadi, M Madahi   +4 more
doaj  

A Single Aplysia Neurotrophin Mediates Synaptic Facilitation via Differentially Processed Isoforms

Cell Reports, 2013
Neurotrophins control the development and adult plasticity of the vertebrate nervous system. Failure to identify invertebrate neurotrophin orthologs, however, has precluded studies in invertebrate models, limiting our understanding of fundamental aspects
Stefan R. Kassabov, Yun-Beom Choi, Kevin A. Karl, Harshad D. Vishwasrao, Craig H. Bailey, Eric R. Kandel   +5 more
doaj   +1 more source

Sodium Phenylbutyrate Enhances Astrocytic Neurotrophin Synthesis via Protein Kinase C (PKC)-mediated Activation of cAMP-response Element-binding Protein (CREB)

Journal of Biological Chemistry, 2013
Background: Increase in neurotrophic factors in the brain is a possible therapeutic approach for different neurodegenerative disorders. Results: Sodium phenylbutyrate, an FDA-approved drug for hyperammonemia, increases neurotrophic factors in brain cells
Grant T. Corbett, Avik Roy, K. Pahan
semanticscholar   +1 more source

CORONIS symposium 2023: Scientific and clinical frontiers in ocular surface innervation

Acta Ophthalmologica, EarlyView.
Abstract The 5th CORONIS Symposium, held during the 2023 Congress of the European Association for Vision and Eye Research (EVER), highlighted the growing importance of ocular surface innervation in eye surface disorders. This article summarises the insights and perspectives shared during the symposium, which focused on the clinical relevance of ocular ...
Anat Galor, Juana Gallar, M. Carmen Acosta, Víctor Meseguer, José Manuel Benítez‐Del‐Castillo, Oliver Stachs, Nóra Szentmáry, Piera Versura, Wolfgang G. K. Müller‐Lierheim, Carlos Belmonte, Jesús Pujol‐Martí   +10 more
wiley   +1 more source

Fetal growth restriction adversely impacts trajectory of hippocampal neurodevelopment and function

Brain Pathology, EarlyView.
Hippocampal neuron dendritogenesis occurs rapidly in late fetal gestation and forms the foundation for connectivity and long term function. Fetal growth restriction caused by placental insufficiency is associated with reduced dendritogenesis in hippocampal neurons, resulting in a significant decrease in the trajectory of neuro‐development.
Ingrid Dudink, Amy E. Sutherland, Margie Castillo‐Melendez, Elham Ahmadzadeh, Tegan A. White, Atul Malhotra, Harold A. Coleman, Helena C. Parkington, Justin M. Dean, Yen Pham, Tamara Yawno, Tara Sepehrizadeh, Graham Jenkin, Emily J. Camm, Beth J. Allison, Suzanne L. Miller   +15 more
wiley   +1 more source

Genetic Dissection of Neurotrophin Signaling through the p75 Neurotrophin Receptor

Cell Reports, 2012
Structural determinants underlying signaling specificity in the tumor necrosis factor receptor superfamily (TNFRSF) are poorly characterized, and it is unclear whether different signaling outputs can be genetically dissociated.
Ioannis Charalampopoulos, Annalisa Vicario, Iosif Pediaditakis, Achille Gravanis, Anastasia Simi, Carlos F. Ibáñez   +5 more
doaj   +1 more source

The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases

Cell Proliferation, EarlyView.
Polymeric nanoparticles represent promising drug (gene) delivery carriers to the brain due to their unique advantages to facilitate the penetration of blood–brain barrier and endocytosis of neuronal cells in neurodegenerative diseases. ABSTRACT In spite of great advances in modern medicine, there are a few effective strategies for the treatment of ...
Lian Jin, Libo Nie, Yan Deng, Ghulam Jilany Khana, Nongyue He   +4 more
wiley   +1 more source