Results 91 to 100 of about 55,877 (286)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

p75NTR Promotes Circadian‐Driven Mineralization During Tooth Development via CK2/PER2 Pathway

Cell Proliferation, EarlyView.
The diagram illustrates how the circadian rhythm regulates the p75NTR‐CK2‐PER2 axis, driving rhythmic biomineralisation during tooth development. ABSTRACT Circadian rhythm is an essential biological process that synchronises physiological activities with environmental light/dark cycles.
Manzhu Zhao, Hongyan Yuan, Di Wang, Meng Li, Bo Xie, Xuqiang Zou, Mingjie Lu, Ye Qiu, Jinlin Song   +8 more
wiley   +1 more source

Expression of neurotrophin receptors during rat tooth development is developmentally regulated, independent of innervation, and suggests functions in the regulation of morphogenesis and innervation [PDF]

, 1996
Keijo Luukko, Maxim Moshnyakov, Kirsi Sainio, Märt Saarma, Hannu Sariola, Irma Thesleff   +5 more
openalex   +1 more source

The transcriptomic signature of DEPDC5 KO induced mTOR hyperactivation in human neurons and its response to rapamycin treatment

Epilepsia, EarlyView.
Abstract Objective Mutations of the DEP Domain Containing 5 gene (DEPDC5), a mechanistic Target of Rapamycin (mTOR) inhibitor involved in amino acid sensing, are associated with neurological diseases such as epilepsy and/or autism spectrum disorder (ASD). Loss of DEPDC5 impacts early neuronal development via mTOR hyperactivity.
Mattson S. O. Jones, Silvia Lindlar, Johannes Ludwig, Regina Waltes, Afsheen Kumar, Sophie v. Brauchitsch, Andrea Rossi, Evelyn Ullrich, Stefan Momma, Christine M. Freitag, Jasmin K. Hefendehl, Karl Martin Klein, Felix Rosenow, Denise Haslinger, Andreas G. Chiocchetti   +14 more
wiley   +1 more source

Optimizing transport methods to preserve function of self‐innervating muscle cells for laryngeal injection

Laryngoscope Investigative Otolaryngology
Objectives Recently, our laboratory has discovered a self‐innervating population of muscle cells, called motor endplate‐expressing cells (MEEs). The cells innately release a wide variety of neurotrophic factors into the microenvironment promoting ...
Samuel L. Kaefer, Lujuan Zhang, Sarah Brookes, Rachel A. Morrison, Sherry Voytik‐Harbin, Stacey Halum   +5 more
doaj   +1 more source

The relationship between psychological distress and neurotrophins in patients with alopecia areata: A crosssectional study

Turkderm Turkish Archives of Dermatology and Venereology
Background and Design: Alopecia areata (AA) is a common, chronic, autoimmune disease that causes psychological effects on patients. Distress and psychological factors play roles in the onset and flares of the disease.
Hatice Parlak Subaşı, Hilal Kaya Erdoğan, Ersoy Acer, Evin Kocatürk, Ali Ercan Altınöz, Zeynep Nurhan Saraçoğlu, Muzaffer Bilgin   +6 more
doaj   +1 more source

Exploring the roles of conserved context‐dependent cis‐regulatory elements (cdCREs) in multicellularity, human health and disease

The FEBS Journal, EarlyView.
Conserved context‐dependent cis‐regulatory elements act as a major reservoir of disease‐associated polymorphisms in the human genome and are also affected by epigenetic change. This ‘state‐of‐the‐art’ review explores the latest developments in studying these enigmatic elements and how the effects of disease‐associated polymorphisms and environmentally ...
Andrew McEwan, Alexander Rattray, Greg Hutchings, Elizabeth Hay, Chris Murgatroyd, Alasdair MacKenzie   +5 more
wiley   +1 more source

Expression of Neurotrophin-3 and trkC following Focal Cerebral Ischemia in Adult Rat Brain with Treadmill Exercise [PDF]

, 2017
Jin Young Chung, Min-Wook Kim, Wooseok Im, In Koo Hwang, Moon-Suk Bang, Manho Kim   +5 more
openalex   +1 more source

Bacterial porphyrins in healthy skin: Microbiota components impact melanogenesis and age‐related processes leading to Porphyr'ageing

International Journal of Cosmetic Science, EarlyView.
Porphyrins, previously linked only to acne inflammation, are now implicated in skin ageing. Their presence correlates with increased melanin, inflammation, and oxidative stress, contributing to premature ageing signs. This study introduces the concept of “Porphyr'ageing,” highlighting the detrimental effects of bacterial metabolites on skin health and ...
Marie Meunier, Morgane De Tollenaere, Cyrille Jarrin, Emilie Chapuis, Marine Bracq, Laura Lapierre, Catherine Zanchetta, Jean Tiguemounine, Amandine Scandolera, Romain Reynaud   +9 more
wiley   +1 more source

Effects of Psychosocial Interventions on Loneliness Amongst Long‐Term Care Residents: A Systematic Review and Meta‐Analysis

Journal of Advanced Nursing, EarlyView.
ABSTRACT Background Loneliness significantly affects the physical and mental health of older adults, particularly those in long‐term care settings. Despite the high prevalence of loneliness, comprehensive reviews on psychosocial interventions targeting loneliness in these populations are scarce.
Jodie Cheuk‐Yan Szeto, Lily Man‐Lee Chan, Wilfred Wing‐Fung Sin, Daniel Yee‐Tak Fong, Jojo Yan‐Yan Kwok   +4 more
wiley   +1 more source