Results 111 to 120 of about 44,486 (289)

Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons [PDF]

, 2008
Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions.
Georgiev, Danko, Kambe, Yuki, Taniura, Hideo, Yoneda, Yukio   +3 more
core  

Positive autoregulation of GDNF levels in the ventral tegmental area mediates long-lasting inhibition of excessive alcohol consumption. [PDF]

, 2011
Glial cell line-derived neurotrophic factor (GDNF) is an essential growth factor for the survival and maintenance of the midbrain dopaminergic (DA-ergic) neurons.
Ahmadiantehrani, S, Barak, S, Kharazia, V, Ron, D   +3 more
core   +3 more sources

CORONIS symposium 2023: Scientific and clinical frontiers in ocular surface innervation

Acta Ophthalmologica, EarlyView.
Abstract The 5th CORONIS Symposium, held during the 2023 Congress of the European Association for Vision and Eye Research (EVER), highlighted the growing importance of ocular surface innervation in eye surface disorders. This article summarises the insights and perspectives shared during the symposium, which focused on the clinical relevance of ocular ...
Anat Galor, Juana Gallar, M. Carmen Acosta, Víctor Meseguer, José Manuel Benítez‐Del‐Castillo, Oliver Stachs, Nóra Szentmáry, Piera Versura, Wolfgang G. K. Müller‐Lierheim, Carlos Belmonte, Jesús Pujol‐Martí   +10 more
wiley   +1 more source

Involvement of ras p2I in Neurotrophin-induced Response of Sensory, but Not Sympathetic Neurons [PDF]

, 1993
Little is known about the signal transduction mechanisms involved in the response to neurotrophins and other neurotrophic factors in neurons, beyond the activation of the tyrosine kinase activity of the neurotrophin receptors belonging to the trk family.
Barde, Y. A., Borasio, Gian Domenico, Heumann, R., Markus, A., Wittinghofer, A.   +4 more
core   +3 more sources

Fetal growth restriction adversely impacts trajectory of hippocampal neurodevelopment and function

Brain Pathology, EarlyView.
Hippocampal neuron dendritogenesis occurs rapidly in late fetal gestation and forms the foundation for connectivity and long term function. Fetal growth restriction caused by placental insufficiency is associated with reduced dendritogenesis in hippocampal neurons, resulting in a significant decrease in the trajectory of neuro‐development.
Ingrid Dudink, Amy E. Sutherland, Margie Castillo‐Melendez, Elham Ahmadzadeh, Tegan A. White, Atul Malhotra, Harold A. Coleman, Helena C. Parkington, Justin M. Dean, Yen Pham, Tamara Yawno, Tara Sepehrizadeh, Graham Jenkin, Emily J. Camm, Beth J. Allison, Suzanne L. Miller   +15 more
wiley   +1 more source

Role of the RAB27/SYTL Axis in Tumor Microenvironment Construction

Cancer Science, EarlyView.
This review focuses on the role of the RAB27/SYTL axis in various cancer types associated with tumor microenvironment modifications. The importance of this pathway and the potential therapeutic strategies targeting vesicle production for the treatment of cancer are also discussed.
Miwa Tanaka, Takuro Nakamura
wiley   +1 more source

Molecular Biomarkers Predictive of Sertraline Treatment Response in Young Children With Autism Spectrum Disorder. [PDF]

, 2020
Sertraline is one among several selective serotonin reuptake inhibitors (SSRIs) that exhibited improvement of language development in Autism Spectrum Disorder (ASD); however, the molecular mechanism has not been elucidated.
Alolaby, Reem Rafik, Durbin-Johnson, Blythe, Hagerman, Randi, Jasoliya, Mittal, Jiraanont, Poonnada, Tang, Hiu-Tung, Tassone, Flora   +6 more
core  

The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases

Cell Proliferation, EarlyView.
Polymeric nanoparticles represent promising drug (gene) delivery carriers to the brain due to their unique advantages to facilitate the penetration of blood–brain barrier and endocytosis of neuronal cells in neurodegenerative diseases. ABSTRACT In spite of great advances in modern medicine, there are a few effective strategies for the treatment of ...
Lian Jin, Libo Nie, Yan Deng, Ghulam Jilany Khana, Nongyue He   +4 more
wiley   +1 more source

Voluntary running wheel activity reduces seizure burden and affords neuroprotection in a mouse model of acquired epilepsy

Epilepsia, EarlyView.
Abstract Objective Physical exercise may improve neurological deficits and neuronal damage after acute brain injuries and decrease established seizures. We investigated whether voluntary running wheel (RW) activity affects epileptogenesis in a mouse model of acquired epilepsy compared to sedentary mice.
Valentina Kebede, Rossella Di Sapia, Nicole Tonesi, Massimo Rizzi, Silvia Balosso, Daniele Spallaci, Ilaria Craparotta, Laura Pasetto, Valentina Bonetto, Gerardo Marsella, Luca Porcu, Giorgio Rosati, Alessandro Ieraci, Annamaria Vezzani   +13 more
wiley   +1 more source

Activation of adenosine A2A receptors induces TrkB translocation and increases BDNF-mediated phospho-TrkB localization in lipid rafts : implications for neuromodulation [PDF]

, 2010
Copyright © 2010 the authorsBrain-derived neurotrophic factor (BDNF) signaling is critical for neuronal development and transmission. Recruitment of TrkB receptors to lipid rafts has been hown to be necessary for the activation of specific signaling ...
Assaife-Lopes, Natália, Chao, Moses V., Pereira, Daniela B., Ribeiro, Joaquim A., Sebastião, Ana M, Sousa, Vasco C.   +5 more
core   +1 more source