This manuscript reviews the function and fundamental characteristics of the neurotrophins and their receptors to introduce the reader to the differential effects exhibited by the neurotrophins; brain-derived neurotrophic factor and neurotrophin 4/5 when ...
Elizabeth Hernandez-Echeagaray
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Recent Advances in the Molecular and Cellular Mechanisms of gp120-Mediated Neurotoxicity
Axonal degeneration and loss of synapses are often seen in different brain areas of people living with human immunodeficiency virus (HIV). Nevertheless, the underlying causes of the pathological alterations observed in these individuals are poorly ...
Valeria Avdoshina, Italo Mocchetti
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TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death [PDF]
Newborn mice carrying targeted mutations in genes encoding neurotrophins or their signaling Trk receptors display severe neuronal deficits in the peripheral nervous system but not in the CNS. In this study, we show that trkB (¿/¿) mice have a significant
Alcántara Horrillo, Soledad +5 more
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Neurotrophins as Therapeutic Agents for Parkinson’s Disease; New Chances From Focused Ultrasound?
Magnetic Resonance–guided Focused Ultrasound (MRgFUS) represents an effective micro-lesioning approach to target pharmaco-resistant tremor, mostly in patients afflicted by essential tremor (ET) and/or Parkinson’s disease (PD).
Alessandro Stefani +9 more
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Drosophila Neurotrophins Reveal a Common Mechanism for Nervous System Formation [PDF]
Neurotrophic interactions occur in Drosophila, but to date, no neurotrophic factor had been found. Neurotrophins are the main vertebrate secreted signalling molecules that link nervous system structure and function: they regulate neuronal survival ...
Aberle +136 more
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Nörotrofinler, nöronların sağkalımını ve fonksiyonlarını etkileyen, sinaptik fonksiyonu ve sinaptik plastisiteyi kontrol eden polipeptid yapılı büyüme faktör ailesidir. Nörotrofin ailesi üyeleri, sinir büyüme faktörü, beyin kaynaklı nörotrofik faktör, nörotrofin-3, nörotrofin-4/5, nörotrofin-6, ve nörotrofin7’dir.
KAZAK, Filiz, YARIM, Gül Fatma
openaire +4 more sources
Recent advances in understanding neurotrophin signaling [version 1; referees: 2 approved]
The nerve growth factor family of growth factors, collectively known as neurotrophins, are evolutionarily ancient regulators with an enormous range of biological functions.
Mark Bothwell
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Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant disease with a unique tumor microenvironment surrounded by an interlaced network of cancer and noncancerous cells.
Jingbo Li, Rui Kang, Daolin Tang
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The self-organization of combinatoriality and phonotactics in vocalization systems [PDF]
This paper shows how a society of agents can self-organize a shared vocalization system that is discrete, combinatorial and has a form of primitive phonotactics, starting from holistic inarticulate vocalizations. The originality of the system is that: (1)
Oudeyer, Dr. P-Y.
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Angiogenesis in Gynecological Cancers: Role of Neurotrophins
Angiogenesis, or generation of new blood vessels from other pre-existing, is a key process to maintain the supply of nutrients and oxygen in tissues. Unfortunately, this process is exacerbated in pathologies such as retinopathies and cancers with high ...
Maritza P. Garrido +6 more
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