Results 41 to 50 of about 441,679 (347)

Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility

Nature, 2020
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein substitution D614G became dominant during the coronavirus disease 2019 (COVID-19) pandemic1,2. However, the effect of this variant on viral spread and vaccine efficacy remains
Jessica A. Plante, Yang Liu, Jianying Liu, Hongjie Xia, Bryan A. Johnson, K. Lokugamage, Xianwen Zhang, Antonio E. Muruato, Jing Zou, Camila R. Fontes-Garfias, D. Mirchandani, Dionna Scharton, J. Bilello, Z. Ku, Z. An, Birte K. Kalveram, Alexander N. Freiberg, Vineet D. Menachery, Xuping Xie, K. Plante, S. Weaver, P. Shi   +21 more
semanticscholar   +1 more source

Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

Nature Microbiology, 2021
Understanding the molecular basis for immune recognition of SARS-CoV-2 spike glycoprotein antigenic sites will inform the development of improved therapeutics. We determined the structures of two human monoclonal antibodies–AZD8895 and AZD1061–which form
Jinhui Dong, Seth J. Zost, Allison J. Greaney, Tyler N. Starr, A. Dingens, E. Chen, Rita E. Chen, J. Case, Rachel E. Sutton, P. Gilchuk, Jessica Rodriguez, Erica Armstrong, Christopher Gainza, Rachel S. Nargi, E. Binshtein, Xuping Xie, Xianwen Zhang, P. Shi, James Logue, S. Weston, M. McGrath, M. Frieman, Tyler Brady, K. Tuffy, H. Bright, Y. Loo, P. McTamney, M. Esser, R. Carnahan, M. Diamond, J. Bloom, J. Crowe   +31 more
semanticscholar   +1 more source

Broad neutralization of SARS-related viruses by human monoclonal antibodies

Science, 2020
Seeking broad protection As scientists develop therapeutic antibodies and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the risk of emergent coronaviruses makes it important to also identify broadly protective antibodies.
Anna Z. Wec, D. Wrapp, A. Herbert, Daniel P. Maurer, Denise Haslwanter, M. Sakharkar, R. Jangra, M. Dieterle, A. Lilov, Deli Huang, Longping V. Tse, N. Johnson, C. Hsieh, Nianshuang Wang, J. Nett, E. Champney, Irina Burnina, Michael E. Brown, Shu Lin, M. Sinclair, Carl Johnson, Sarat Pudi, R. Bortz, A. Wirchnianski, Ethan Laudermilch, Catalina Florez, J. Fels, Cecilia M. O’Brien, B. Graham, D. Nemazee, D. Burton, R. Baric, J. Voss, K. Chandran, J. Dye, J. McLellan, L. Walker   +36 more
semanticscholar   +1 more source

Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529

bioRxiv, 2021
With B.1.1.529 SARS-CoV-2 variant’s rapid spread and substantially increased resistance to neutralization by vaccinee and convalescent sera, monoclonal antibodies with potent neutralization are eagerly sought.
T. Zhou, Lingshu Wang, J. Misasi, A. Pegu, Yi Zhang, Darcy R. Harris, A. Olia, C. A. Talana, E. Yang, Man Chen, M. Choe, W. Shi, I-Ting Teng, A. Creanga, C. Jenkins, K. Leung, Tracy Liu, Erik-Stephane D. Stancofski, T. Stephens, Baoshan Zhang, Y. Tsybovsky, B. Graham, J. Mascola, N. Sullivan, P. Kwong   +24 more
semanticscholar   +1 more source

Recovery of lithium salt from spent lithium‐ion battery by less polar solvent wash and water extraction

Carbon Neutralization, 2023
The lithium hexafluorophosphate (LiPF6) in spent lithium‐ion batteries (LIBs) is a potentially valuable resource and a significant environmental pollutant. Unfortunately, most of the LiPF6 in a spent LIB is difficult to extract because the electrolyte is
Hao Du, Yuqiong Kang, Chenglei Li, Yun Zhao, Yao Tian, Jian Lu, Zhaoyang Chen, Ning Gao, Zhike Li, John Wozny, Tao Li, Li Wang, Naser Tavajohi, Feiyu Kang, Baohua Li   +14 more
doaj   +1 more source

Biochar‐based interfacial evaporation materials derived from lignosulfonate for efficient desalination

Carbon Neutralization, 2023
The solar‐driven interfacial evaporation has attracted great attention for the purpose of alleviating freshwater shortage. Lignosulfonate (LS), a main byproduct of sulfite pulping processes, is an abundant natural resource but has not been reasonably ...
Shilin Chen, Lan Sun, Yuqing Huang, Dongjie Yang, Mingsong Zhou, Dafeng Zheng   +5 more
doaj   +1 more source

Insights into the synergistic effect between nickel and molybdenum for catalyzing urea electrooxidation

Carbon Neutralization, 2022
The efficiency of many clean technologies, such as urea fuel cells, hydrogen production from urea‐containing water splitting, and sewage treatment, and so forth, is restricted due to the sluggish kinetics of the urea oxygen reaction (UOR).
Jiaqi Wang, Funian Mo, Jinbo Fei, Wei Ling, Mangwei Cui, Hao Lei, Li Jiang, Yan Huang   +7 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry

Nature Communications, 2021
Understanding the mechanism for antibody neutralization of SARS-CoV-2 is critical for the development of effective therapeutics and vaccines. We recently isolated a large number of monoclonal antibodies from SARS-CoV-2 infected individuals.
J. Ge, Ruoke Wang, B. Ju, Qi Zhang, Jing Sun, Peng Chen, Senyan Zhang, Yuling Tian, S. Shan, Lin Cheng, Bingjie Zhou, Shuo Song, Juanjuan Zhao, Haiyan Wang, Xuanling Shi, Q. Ding, Lei Liu, Jincun Zhao, Zheng Zhang, Xinquan Wang, Linqi Zhang   +20 more
semanticscholar   +1 more source

State Neutrality [PDF]

, 2012
This article attempts to spell out the main tenets of the principle of state neutrality and to explain how they hang together. It examines the central objections, and explores revisions that may enhance the theory's defensibility. Specifically, it discusses neutrality as non-discrimination, neutrality as shared reasons, objections to liberal neutrality,
openaire   +2 more sources