Results 61 to 70 of about 454,570 (346)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Trace nano-Ti addition for graphene nanoplatelets/copper composites to simultaneously enhance strength-ductility and wear resistance

Journal of Materials Research and Technology
Graphene nanoplatelets (GNPs)/copper composites containing nano-Ti addition were prepared using the vacuum hot-pressing sintering process. The effect of Nano-Ti on microstructure and mechanical properties of GNPs/copper composite was investigated. Before
Xinjiang Zhang, Ming Yang, Cailiu Yin, Jianlie Liang, Meng He, Zirun Yang   +5 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Phonetic and Phonological Effects of Depressor Consonants in Malawian CiTonga

Nordic Journal of African Studies, 2022
In this paper we show that certain consonants have the effect of depressing the tone on adjacent vowels in Malawian CiTonga, a Bantu language spoken mainly in Nkhata Bay. We argue that some of these effects are phonological, changing High vowels to Low.
Winfred Mkochi, Jamilläh Rodriguez, Lee Bickmore   +2 more
doaj   +1 more source

Broadly-Neutralizing Antibodies Against Emerging SARS-CoV-2 Variants [PDF]

, 2021
Lok Bahadur Shrestha, Nicodemus Tedla, Rowena A. Bull   +2 more
openalex   +1 more source

Neutralization against Omicron SARS-CoV-2 from previous non-Omicron infection

bioRxiv, 2021
The spread of the Omicron SARS-CoV-2 variant underscores the importance of analyzing the cross-protection from previous non-Omicron infection. We have developed a high-throughput neutralization assay for Omicron SARS-CoV-2 by engineering the Omicron ...
Jing Zou, Hongjie Xia, Xuping Xie, Chaitanya Kurhade, R. Machado, S. Weaver, Ping Ren, P. Shi   +7 more
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Interleukin‐6 neutralization ameliorates symptoms in prematurely aged mice [PDF]

, 2021
Stefano Squarzoni, Elisa Schena, Patrizia Sabatelli, Elisabetta Mattioli, Cristina Capanni, Vittoria Cenni, Maria Rosaria D’Apice, Davide Andrenacci, Giuseppe Sarli, Valeria Pellegrino, Anna Festa, Fabio Baruffaldi, Gianluca Storci, Massimiliano Bonafè, Catia Barboni, Mara Sanapo, Anna Zaghini, Giovanna Lattanzi   +17 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Enhanced SARS-CoV-2 neutralization by dimeric IgA

Science Translational Medicine, 2020
Human dimeric IgA antibodies are potent neutralizers of SARS-CoV-2. Two is better than one for COVID-19 Most individuals that become infected with SARS-CoV-2, the virus that causes COVID-19, produce neutralizing antibodies against the virus. However, the
Zijun Wang, Julio C. C. Lorenzi, F. Muecksch, Shlomo Finkin, Charlotte Viant, C. Gaebler, M. Cipolla, Hans-Heinrich Hoffman, Thiago Y. Oliveira, D. Oren, Victor Ramos, Lilian Nogueira, E. Michailidis, D. Robbiani, A. Gazumyan, C. Rice, T. Hatziioannou, P. Bieniasz, M. Caskey, M. Nussenzweig   +19 more
semanticscholar   +1 more source