Results 111 to 120 of about 1,883,437 (383)

A fine-tuned yeast surface-display/secretion platform enables the rapid discovery of neutralizing antibodies against Clostridioides difficile toxins

Microbial Cell Factories, 2023
Background Neutralizing antibody plays a key role in protecting hosts from invasive pathogens and their virulent components. Current high-throughput assays for antibody screening are based on binding activities.
Ying Sun, Yongrong Zhang, Hua Yu, Ashley Saint Fleur, Di Yu, Zhiyong Yang, Hanping Feng   +6 more
doaj   +1 more source

Evidence for West Nile Virus and Usutu Virus Infections in Wild and Resident Birds in Germany, 2017 and 2018 [PDF]

, 2019
Wild birds play an important role as reservoir hosts and vectors for zoonotic arboviruses and foster their spread. Usutu virus (USUV) has been circulating endemically in Germany since 2011, while West Nile virus (WNV) was first diagnosed in several bird ...
Eiden, Martin, Fast, Christine, Fischer, Dominik, Groschup, Martin H., Keller, Markus, Korbel, Rüdiger, Lierz, Michael, Lühken, Renke, Michel, Friederike, Müller, Kerstin, Reuschel, Maximilian, Rinder, Monika, Schmidt, Volker, Schmoock, Martina, Schwehn, Rebekka, Sieg, Michael, Urbaniak, Sylvia, Vahlenkamp, Thomas W., Wysocki, Patrick, Ziegler, Ute   +19 more
core   +2 more sources

Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Hyperimmune Immunoglobulin Demonstrates Potent Neutralization and Antibody-Dependent Cellular Cytotoxicity and Phagocytosis Through N and S Proteins [PDF]

, 2021
José María Soberanes Díez, Carolina S. Romero, Maria Cristina Cruz, Peter Vandeberg, W. Keither Merritt, Edwards Pradenas, Benjamin Trinité, Julià Blanco, Bonaventura Clotet, Todd Willis, Rodrigo Gajardo   +10 more
openalex   +1 more source

Comparison of fluorescent-antibody, neutralizing-antibody, and complement-enhanced neutralizing-antibody assays for detection of serum antibody to respiratory syncytial virus [PDF]

Journal of Clinical Microbiology, 1981
A comparison of three assays for the detection of serum antibody to respiratory syncytial virus (RSV) was carried out on 47 serum samples obtained sequentially from infants and young children with RSV infection. Neutralizing-antibody (NA) activity was determined by a semimicromethod of plaque reduction. Complement-enhanced NA activity was determined by
T N, Kaul, R C, Welliver, P L, Ogra
openaire   +2 more sources

Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients

Cellular & Molecular Immunology, 2020
ARS-CoV-2 outbreak is a world-wide pandemic. The Spike protein plays central role in cell entry of the virus, and triggers significant immuno-response. Our understanding of the immune-response against S protein is still very limited.
Yang Li, Dan-yun Lai, Hai-nan Zhang, He-wei Jiang, Xiao-long Tian, Ming-liang Ma, H. Qi, Q.-f. Meng, Shu-juan Guo, Yanling Wu, Wei Wang, X. Yang, Da-wei Shi, Junbiao Dai, T. Ying, Jie Zhou, S. Tao   +16 more
semanticscholar   +1 more source

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann, Michelle M. Sonsalla, Cora Luzinski, Fernando Zacahua, David A. Harris, Dudley W. Lamming, Albee Messing   +6 more
wiley   +1 more source

Ability of vaccine strain induced antibodies to neutralize field isolates of caliciviruses from Swedish cats [PDF]

, 2015
Background: Feline calicivirus (FCV) is a common cause of upper respiratory tract disease in cats worldwide. Its characteristically high mutation rate leads to escape from the humoral immune response induced by natural infection and/or vaccination and ...
Berndtsson, Louise Treiberg, Hosie, Margaret, Lindhe, Anna, Samman, Ayman, Thibault, Jean-Christophe, Wensman, Jonas Johansson   +5 more
core   +2 more sources

Potent human neutralizing antibodies elicited by SARS-CoV-2 infection

bioRxiv, 2020
The pandemic caused by emerging coronavirus SARS-CoV-2 presents a serious global public health emergency in urgent need of prophylactic and therapeutic interventions.
B. Ju, Qi Zhang, Xiangyang Ge, Ruoke Wang, Jiazhen Yu, S. Shan, Bingjie Zhou, Shuo Song, Xian-Chun Tang, Jinfang Yu, J. Ge, J. Lan, Jing Yuan, Haiyan Wang, Juanjuan Zhao, Shuye Zhang, Youchun Wang, Xuanling Shi, Lei Liu, Xinquan Wang, Zheng Zhang, Linqi Zhang   +21 more
semanticscholar   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Effects of pre-existing anti-adenovirus antibodies on transgene expression levels and therapeutic efficacies of arming oncolytic adenovirus

Scientific Reports, 2022
Oncolytic adenoviruses (OAds), most of which are based on species C human adenovirus serotype 5 (Ad5) (OAd5), have recently received much attention as potential anticancer agents.
Ryosuke Ono, Fumitaka Nishimae, Takuro Wakida, Fuminori Sakurai, Hiroyuki Mizuguchi   +4 more
doaj   +1 more source