Results 21 to 30 of about 1,017,928 (387)

Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome

Blood, 2020
COVID-19 affects millions of patients worldwide, with clinical presentation ranging from isolated thrombosis to acute respiratory distress syndrome (ARDS) requiring ventilator support.
E. Middleton, Xue-Yan He, F. Denorme, Robert A. Campbell, David Ng, S. Salvatore, Maria Mostyka, Amelia Baxter-Stoltzfus, A. Borczuk, M. Loda, M. Cody, B. Manne, I. Portier, Estelle M. Harris, Aaron C Petrey, E. Beswick, Aleah F. Caulin, A. Iovino, Lisa M. Abegglen, A. Weyrich, M. Rondina, M. Egeblad, J. Schiffman, C. C. Yost   +23 more
semanticscholar   +1 more source

Neutrophils and Asthma

Diagnostics, 2022
Although eosinophilic inflammation is characteristic of asthma pathogenesis, neutrophilic inflammation is also marked, and eosinophils and neutrophils can coexist in some cases. Based on the proportion of sputum cell differentiation, asthma is classified into eosinophilic asthma, neutrophilic asthma, neutrophilic and eosinophilic asthma, and ...
Akira Yamasaki, Ryota Okazaki, Tomoya Harada   +2 more
openaire   +3 more sources

Innate Host Defense against Klebsiella pneumoniae and the Outlook for Development of Immunotherapies

Journal of Innate Immunity, 2021
Klebsiella pneumoniae (K. pneumoniae) is a Gram-negative commensal bacterium and opportunistic pathogen. In healthy individuals, the innate immune system is adept at protecting against K. pneumoniae infection.
Clement Opoku-Temeng, Natalia Malachowa, Scott D. Kobayashi, Frank R. DeLeo   +3 more
doaj   +1 more source

Neutrophils in Psoriasis [PDF]

Frontiers in Immunology, 2019
Neutrophils are the most abundant innate immune cells. The pathogenic roles of neutrophils are related to chronic inflammation and autoimmune diseases. Psoriasis is a chronic systemic inflammatory disease affecting ~2-3% of the world population. The abundant presence of neutrophils in the psoriatic skin lesions serves as a typical histopathologic ...
Chih-Chao Chiang, Chih-Chao Chiang, Chih-Chao Chiang, Wei-Jen Cheng, Wei-Jen Cheng, Wei-Jen Cheng, Michal Korinek, Michal Korinek, Michal Korinek, Cheng-Yu Lin, Tsong-Long Hwang, Tsong-Long Hwang, Tsong-Long Hwang, Tsong-Long Hwang, Tsong-Long Hwang, Tsong-Long Hwang   +15 more
openaire   +4 more sources

S100A8/A9 Is a Marker for the Release of Neutrophil Extracellular Traps and Induces Neutrophil Activation

Cells, 2022
Neutrophils are the most abundant innate immune cells in the circulation and they are the first cells recruited to sites of infection or inflammation. Almost half of the intracellular protein content in neutrophils consists of S100A8 and S100A9, though ...
Evelien G. G. Sprenkeler, J. Zandstra, Nadine D. van Kleef, Ines Goetschalckx, Bibian Verstegen, C. Aarts, H. Janssen, A. Tool, G. van Mierlo, R. van Bruggen, I. Jongerius, T. Kuijpers   +11 more
semanticscholar   +1 more source

Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions. [PDF]

, 2017
Integrin activation is required for neutrophil functions. Impaired integrin activation on neutrophils is the hallmark of leukocyte adhesion deficiency (LAD) syndrome in humans, characterized by impaired leukocyte recruitment and recurrent infections. The
Bardel, Bernadette, Block, Helena, Bokemeyer, Arne, Boras, Mark, Heitplatz, Barbara, Kliche, Stefanie, Lowell, Clifford, Reinhold, Annegret, Rossaint, Jan, Van Marck, Veerle, Volmering, Stephanie, Zarbock, Alexander   +11 more
core   +2 more sources

Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity [PDF]

Open Biology, 2012
Leucocytes form the principal cellular components of immunity and inflammation, existing as multiple subsets defined by distinct phenotypic and functional profiles. To date, this has most notably been documented for lymphocytes and monocytes. In contrast,
Martina Beyrau, Jennifer Victoria Bodkin, Sussan Nourshargh   +2 more
doaj   +1 more source

Neutrophils Lose the Capacity to Suppress T Cell Proliferation Upon Migration Towards Inflamed Joints in Juvenile Idiopathic Arthritis

Frontiers in Immunology, 2022
Neutrophils are highly abundant in synovial fluid of rheumatic inflamed joints. In oligoarticular juvenile idiopathic arthritis (JIA), synovial fluid neutrophils have impaired effector functions and altered phenotype.
Sabine Arve-Butler, Sabine Arve-Butler, Anki Mossberg, Anki Mossberg, Tobias Schmidt, Tobias Schmidt, Charlotte Welinder, Hong Yan, Elisabet Berthold, Elisabet Berthold, Petra Król, Robin Kahn, Robin Kahn   +12 more
doaj   +1 more source

Crucial role of local peroxynitrite formation in neutrophil-induced endothelial cell activation [PDF]

, 2003
Introduction and methods: The reaction of superoxide anions and NO not only results in a decreased availability of NO, but also leads to the formation of peroxynitrite, the role of which in the cardiovascular system is still discussed controversially. In
Gloe, Torsten, Keller, Matthias, Klauss, Volker, Krötz, Florian, Pohl, Ulrich, Schiele, Thomas M., Sohn, Hae-Young, Theisen, Karl, Zahler, Stefan   +8 more
core   +1 more source

Dynamic ROS Production and Gene Expression of Heifers Blood Neutrophil in a Oligofructose Overload Model

Frontiers in Veterinary Science, 2020
Alimentary oligofructose (OF) overload can induce several diseases in cattle, such as ruminal acidosis, laminitis, and synovitis. The role of blood polymorphonuclear neutrophil (PMN) remains unclear during OF overload.
Shuaichen Li, Shuaichen Li, Jiafeng Ding, Jiafeng Ding, Lihong Jiang, Lihong Jiang, Muhammad Abid Hayat, Muhammad Abid Hayat, Qiaozhi Song, Qiaozhi Song, Yuepeng Li, Yuepeng Li, Xianhao Zhang, Xianhao Zhang, Jiantao Zhang, Jiantao Zhang   +15 more
doaj   +1 more source