Results 41 to 50 of about 776,059 (341)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis [PDF]

, 2010
© 2010 Cascão et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
AF Mourao, AK Andersson, Ana F Mourão, Ana M Rodrigues, BW Kirkham, C Gabay, DY Chen, Elsa Vieira-Sousa, ER Vossenaar, FA Houssiau, FC Arnett, G Parsonage, H Kokkonen, Helena Canhão, Henrique S Rosário, HJ Kim, IC Chikanza, Inês Perpétuo, J Cedergren, J Duarte, J Pene, JE Fonseca, JE Fonseca, JF Fries, Joaquim Polido-Pereira, João E Fonseca, K Nagatani, L Petrovic-Rackov, LA Joosten, LK Assi, LK Stamp, Luis Graca, M al-Janadi, M Chabaud, M Pelletier, Maria M Souto-Carneiro, ML Prevoo, Mário V Queiroz, P Barrera, P Weinmann, P Youinou, PE Poubelle, R Cascao, R Cascao, R Segal, RA Moura, Rita A Moura, Rita Cascão, S Kotake, SC Liang, TJ Smeets   +50 more
core   +3 more sources

Investigation of Allogeneic Neutrophil Transfusion in Improving Survival Rates of Severe Infection Mice

Cell Transplantation
The management of granulocytopenia-associated infections is challenging, and a high mortality rate is associated with traditional supportive therapies.
Linbin Li, Yunxi Yang, Zaiwen Guo, Xi Gao, Lu Liu, Jiamin Huang, Bingwei Sun   +6 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Nucleosomes and neutrophil extracellular traps in septic and burn patients [PDF]

, 2017
NETosis is a host defense mechanism associated with inflammation and tissue damage. Experimental models show that platelets and von Willebrand factor (VWF) are key elements for intravascular NETosis. We determined NETosis in septic and burn patients at 1
Carestia, Agostina, D'Atri, Lina Paola, Fandiño, María Eugenia, Fondevila, Carlos, Guzman, María Alejandra, Kaufman, Tomás, Magosevich, Débora, Moreno, María Carolina, Schattner, Mirta Ana   +8 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury. [PDF]

, 2018
BACKGROUND: Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2.

core   +2 more sources

Neutrophil-Camouflaged Stealth Liposomes for Photothermal-Induced Tumor Immunotherapy Through Intratumoral Bacterial Activation

Pharmaceutics
Objective: F. nucleatum, a tumor-resident bacterium colonizing breast cancer (BC), results in an immunosuppressive microenvironment and facilitates tumor growth and metastasis.
Xinxin Chen, Jiang Sun, Tingxian Ye, Fanzhu Li   +3 more
doaj   +1 more source

The Antibody Receptor Fc Gamma Receptor IIIb Induces Calcium Entry via Transient Receptor Potential Melastatin 2 in Human Neutrophils

Frontiers in Immunology, 2021
Human neutrophils express two unique antibody receptors for IgG, the FcγRIIa and the FcγRIIIb. FcγRIIa contains an immunoreceptor tyrosine-based activation motif (ITAM) sequence within its cytoplasmic tail, which is important for initiating signaling. In
Omar Rafael Alemán, Nancy Mora, Carlos Rosales   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source