Results 51 to 60 of about 1,017,928 (387)
The atypical chemokine receptor ACKR2 is protective against sepsis [PDF]
, 2018 Sepsis is a systemic inflammatory response as a result of uncontrolled infections. Neutrophils are the first cells to reach the primary sites of infection and chemokines play a key role in recruiting neutrophils.
Alves-Filho, José Carlos +15 more
core +1 more source
Frontiers in Immunology, 2018 Neutrophils are abundant in the circulation and are one of the immune system's first lines of defense against infection. There has been substantial work carried out investigating the role of neutrophils in malaria and it is clear that during infection neutrophils are activated and are capable of clearing malaria parasites by a number of mechanisms ...
Aitken, EH, Alemu, A, Rogerson, SJ
openaire +5 more sources
Purinergic Regulation of Neutrophil Function
Frontiers in Immunology, 2018 Purinergic signaling, which utilizes nucleotides (particularly ATP) and adenosine as transmitter molecules, plays an essential role in immune system. In the extracellular compartment, ATP predominantly functions as a pro-inflammatory molecule through ...
Xu Wang, Deyu Chen
doaj +1 more source
MiR-223 as a Regulator and Therapeutic Target in Liver Diseases
Frontiers in Immunology, 2022 MicroRNAs (miRNAs) are endogenous non-coding single-stranded small molecule RNAs consisting of 20–24 nucleotides that are highly conserved in species evolution. Expression of miRNAs is strictly tissue-specific, and it is chronological in fungi and plants,
Jiarong Gu +5 more
doaj +1 more source
Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis [PDF]
, 2010 © 2010 Cascão et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
AF Mourao +50 more
core +3 more sources
Role of laboratory markers in predicting severity of acute appendicitis
African Journal of Paediatric Surgery, 2018 Background: Accurately differentiating simple and complicated acute appendicitis (CAA) in children preoperatively can be challenging. The aim of this study is to evaluate the ability of the neutrophil-to-lymphocyte ratio (NLR), total leukocyte count (TLC)
Samarth Virmani +3 more
doaj +1 more source
Regulation of neutrophil senescence by microRNAs [PDF]
, 2011 Neutrophils are rapidly recruited to sites of tissue injury or infection, where they protect against invading pathogens. Neutrophil functions are limited by a process of neutrophil senescence, which renders the cells unable to respond to chemoattractants,
A Bonauer +60 more
core +4 more sources
Immunoreceptors on neutrophils
Seminars in Immunology, 2016 Neutrophils play a critical role in the host defense against infection, and they are able to perform a variety of effector mechanisms for this purpose. However, there are also a number of pathological conditions, including autoimmunity and cancer, in which the activities of neutrophils can be harmful to the host. Thus the activities of neutrophils need
van Rees, Dieke J +4 more
openaire +4 more sources
Circulation Research, 2015 More than a century ago, in 1881, Bizzozero1 discovered platelets and their role in primary hemostasis. Since this founding study, it has been shown that, in addition to the scaffold of platelets and fibrin, other proteins and cells play an important role in thrombus formation and stabilization.
Benoît Ho-Tin-Noé +1 more
openaire +2 more sources
Kinetics of peripheral blood neutrophils in severe coronavirus disease 2019
Clinical & Translational Immunology, 2021 Objectives Emerging evidence of dysregulation of the myeloid cell compartment urges investigations on neutrophil characteristics in coronavirus disease 2019 (COVID‐19).
Mieke Metzemaekers +35 more
doaj +1 more source