Results 51 to 60 of about 776,059 (341)

The atypical chemokine receptor ACKR2 is protective against sepsis [PDF]

, 2018
Sepsis is a systemic inflammatory response as a result of uncontrolled infections. Neutrophils are the first cells to reach the primary sites of infection and chemokines play a key role in recruiting neutrophils.
Alves-Filho, José Carlos, Amaral, Flávio Almeida, Borges, Vanessa, Castanheira, Fernanda Vargas E. Silva, Cunha, Fernando Queiroz, Cunha, Thiago Mattar, Donate, Paula Barbim, Graham, Gerard J., Kanashiro, Alexandre, Liew, Foo Y., Melo, Paulo Henrique, Pallas, Kenneth, Ramalho, Fernando Silva, Russo, Remo Castro, Sônego, Fabiane, Teixeira, Mauro Martins   +15 more
core   +1 more source

Integrated plasma metabolomics and lipidomics profiling highlight distinctive signatures with hashimoto’s thyroiditis

Scientific Reports
Hashimoto’s Thyroiditis (HT) is an autoimmune disorder characterized by metabolic disturbances. However, a comprehensive metabolic and lipid profile of HT has not been reported.
Guoqiang Wang, Xuan Ye, Ting Lu, Yunxi Yang, Bingwei Sun, Hui Xiao   +5 more
doaj   +1 more source

Targeting Neutrophils in Sepsis: From Mechanism to Translation

Frontiers in Pharmacology, 2021
Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Although our understanding in the pathophysiological features of sepsis has increased significantly during the past decades, there is still lack of specific ...
Xiaofei Shen, Ke Cao, Yang Zhao, Junfeng Du, Junfeng Du, Junfeng Du   +5 more
doaj   +1 more source

Neutrophils in Gliomas [PDF]

Frontiers in Immunology, 2017
Neutrophils are the most abundant white blood cells and are the first recruited to inflammatory sites. Neutrophils are an important component of the tumor stroma and can exert both anti-tumoral and pro-tumoral activities, depending on their maturation and activation state.
Matteo Massara, Matteo Massara, Pasquale Persico, Ornella Bonavita, Ornella Bonavita, Valeria Mollica Poeta, Valeria Mollica Poeta, Massimo Locati, Massimo Locati, Matteo Simonelli, Matteo Simonelli, Raffaella Bonecchi, Raffaella Bonecchi   +12 more
openaire   +4 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Deconjugation Kinetics of Glucuronidated Phase II Flavonoid Metabolites by B-glucuronidase from Neutrophils [PDF]

, 2010
Flavonoids are inactivated by phase II metabolism and occur in the body as glucuronides. Mammalian ß-glucuronidase released from neutrophils at inflammatory sites may be able to deconjugate and thus activate flavonoid glucuronides.
Arts, I.C.W., Bartholomé, R., Bast, A., Dagnelie, P.C., Haenen, G., Hollman, P.C.H., Keijer, J., Kroon, P.A., Needs, P.W., Roos, D.   +9 more
core   +2 more sources

Korelasi Absolute Neutrophil Count Selama Kemoterapi dengan Kualitas Hidup pada Anak dengan Leukemia Limfoblastik Akut

Sari Pediatri
Latar belakang. Leukemia merupakan suatu penyakit keganasan sel darah yang berasal dari sumsum tulang. Toksisitas hematologi yang terjadi selama kemoterapi dapat memicu timbulnya perubahan neutrofil yang memunculkan manifestasi klinis sehingga menurunkan
Deta Putrimingtyas, Pridania Vidya, Muhammad Riza   +2 more
doaj   +1 more source

Neutrophilic Thrombophagocytosis

Archives of Pathology & Laboratory Medicine, 2000
Abstract Thrombocytopenia as a complication of B-cell lymphoma usually results from the removal of platelets from the circulation by splenic and hepatic mononuclear phagocytes.1,2 In the present paper, we describe a case of B-cell lymphoma with thrombocytopenia in which the platelets were phagocytosed by the patient's own neutrophilic ...
J C, Lee, K, Tripathy
openaire   +2 more sources

Heterogeneity Among Neutrophils [PDF]

Archivum Immunologiae et Therapiae Experimentalis, 2017
Neutrophils (PMNs) play a key role in innate defence mechanisms. Generally, PMNs were considered to have a homogeneous population of mature and diversified cells. It seems, however, that their pleiotropic action results from the existence of different subpopulations in this group of cells.
Garley, Marzena, Jabłońska, Ewa
openaire   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source