Neutrophil Elastase and Chronic Lung Disease [PDF]
Biomolecules, 2021 Neutrophil elastase (NE) is a major inflammatory protease released by neutrophils and is present in the airways of patients with cystic fibrosis (CF), chronic obstructive pulmonary disease, non-CF bronchiectasis, and bronchopulmonary dysplasia.
Judith A Voynow
exaly +5 more sources
Neutrophil elastase-activatable ratiometric photoacoustic nanoprobes for imaging atherosclerotic plaque vulnerability [PDF]
Nature CommunicationsAtherosclerosis is a leading cause of cardiovascular diseases worldwide. Neutrophil elastase, a key protease secreted by neutrophils, contributes significantly to atherosclerosis by degrading the extracellular matrix and destabilizing the fibrous cap of ...
Hui Cao +14 more
doaj +2 more sources
Research progress on the effect of neutrophil elastase and its inhibitors in respiratory diseases [PDF]
Journal of International Medical ResearchNeutrophil elastase is a serine protease secreted by neutrophils that plays a crucial role in the onset and progression of various respiratory diseases.
Cheng-Cheng Liang +4 more
doaj +2 more sources
Neutrophil elastase in bronchiectasis
Respiratory Research, 2017 The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF.
Andrea Gramegna +8 more
doaj +4 more sources
Value of circulating neutrophil elastase for detecting recurrence of differentiated thyroid cancer [PDF]
Endocrine Connections, 2023 Objective: The inflammatory microenvironment has been implicated in differentiated thyroid cancer (DTC). Inflammatory stimuli induce the release of components of neutrophils into extracellular space, leading to formation of neutrophil extracellular trap (
Hyunjae Lee +6 more
doaj +2 more sources
Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model [PDF]
Intensive Care Medicine ExperimentalBackground Neutrophil granulocytes are important parts of the defence against bacterial infections. Their action is a two-edged sword, the mediators killing the intruding bacteria are at the same time causing tissue damage.
Frida Wilske +15 more
doaj +2 more sources
Neutrophil Elastase Defects in Congenital Neutropenia [PDF]
Frontiers in Immunology, 2021 Severe congenital neutropenia (SCN) is a rare hematological condition with heterogenous genetic background. Neutrophil elastase (NE) encoded by ELANE gene is mutated in over half of the SCN cases. The role of NE defects in myelocytes maturation arrest in
Zuzanna Rydzynska +6 more
doaj +3 more sources
Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses [PDF]
Respiratory Research, 2013 Background Chronic asthma is often associated with neutrophilic infiltration in the airways. Neutrophils contain elastase, a potent secretagogue in the airways, nonetheless the role for neutrophil elastase as well as neutrophilic inflammation in allergen-
Koga Hikari +10 more
doaj +4 more sources
Targeted Library of Phosphonic-Type Inhibitors of Human Neutrophil Elastase [PDF]
MoleculesDespite many years of research, human neutrophil elastase (HNE) still remains an area of interest for many researchers. This multifunctional representative of neutrophil serine proteases is one of the most destructive enzymes found in the human body ...
Karolina Torzyk-Jurowska +2 more
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PLoS ONE, 2022 Infection with the SARS-CoV2 virus can vary from asymptomatic, or flu-like with moderate disease, up to critically severe. Severe disease, termed COVID-19, involves acute respiratory deterioration that is frequently fatal.
Richard Wargodsky +12 more
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