Results 1 to 10 of about 54,312 (148)
Neutrophil elastase inhibitors [PDF]
Expert Opinion on Therapeutic Patents, 2011 Chronic obstructive pulmonary disease (COPD) constitutes a worldwide health problem. There is currently an urgent and unmet need for the development of small molecule therapeutics capable of blocking and/or reversing the progression of the disorder.
Groutas, William C. +2 more
openaire +3 more sources
Neutrophil Elastase and Chronic Lung Disease [PDF]
Biomolecules, 2021 Neutrophil elastase (NE) is a major inflammatory protease released by neutrophils and is present in the airways of patients with cystic fibrosis (CF), chronic obstructive pulmonary disease, non-CF bronchiectasis, and bronchopulmonary dysplasia. Although NE facilitates leukocyte transmigration to the site of infection and is required for clearance of ...
Judith A. Voynow, Meagan Shinbashi
openaire +3 more sources
Human Neutrophil Elastase Degrades SPLUNC1 and Impairs Airway Epithelial Defense against Bacteria [PDF]
, 2013 Background:Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a significant cause of mortality of COPD patients, and pose a huge burden on healthcare. One of the major causes of AECOPD is airway bacterial (e.g.
Bowler, RP +5 more
core +6 more sources
Neutrophil Elastase Defects in Congenital Neutropenia [PDF]
Frontiers in Immunology, 2021 Severe congenital neutropenia (SCN) is a rare hematological condition with heterogenous genetic background. Neutrophil elastase (NE) encoded byELANEgene is mutated in over half of the SCN cases. The role of NE defects in myelocytes maturation arrest in bone marrow is widely investigated; however, the mechanism underlying this phenomenon has still ...
Zuzanna Rydzynska +6 more
openaire +3 more sources
Hemodialysis membrane-related neutrophil dysfunctions and pentoxifylline - a pilot study [PDF]
, 1990 Hemodialysis treatment is associated with activation of neutrophil granulocytes. Pentoxifylline has been shown to inhibit neutrophil activation in vitro and in vivo.
Hoffmann, H. +3 more
core +1 more source
Visceral leishmaniasis patients display altered composition and maturity of neutrophils as well as impaired neutrophil effector functions [PDF]
, 2016 Immunologically, active visceral leishmaniasis (VL) is characterised by profound immunosuppression, severe systemic inflammatory responses and an impaired capacity to control parasite replication.
Adem, E +19 more
core +3 more sources
Earthworm coelomocyte extracellular traps : structural and functional similarities with neutrophil NETs [PDF]
, 2018 ROD UJ /
Joanna Homa
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Triterpenoids as Neutrophil Elastase Inhibitors [PDF]
Natural Product Communications, 2015 Neutrophile elastase has the capacity to degrade elastin, a protein found in the connective tissue of the lungs. Unchecked elastase leads to pulmonary pathologies. Therefore, the development of elastase inhibitors is currently actively pursued in the therapeutic field.
Dom, Guillaume +4 more
openaire +2 more sources
TRPV4-A Missing Link Between Mechanosensation and Immunity [PDF]
, 2020 Transient receptor potential vanilloid-type 4 (TRPV4) cation channel is widely expressed in all tissues as well as in immune cells and its function as mechanosensitive Ca2+ channel seems to be conserved throughout all mammalian species. Of late, emerging
Kuebler, Wolfgang M., Michalick, Laura
core +1 more source
Neutrophil elastase in bronchiectasis
Respiratory Research, 2017 The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF. In this context, NE seems to be a predictor of long-term clinical outcomes and a possible target of treatment.
A. Gramegna +8 more
openaire +4 more sources