Results 111 to 120 of about 54,402 (238)

The Multifaceted Legacy of Thalidomide: Chemistry and Biology Driving Modern Drug Design

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Thalidomide serves as a molecular nexus linking chemistry and biology: advances in synthesis and structural understanding enable protein degradation technologies, while its immunomodulatory activity underpins anti‐inflammatory and anticancer therapies.
Konstantina Nikovia, Michael Kapsalis, Michael Georgoulakis, Athanasios Panousis, Constantinos G. Neochoritis   +4 more
wiley   +1 more source

A Novel Role of Neutrophil Elastase in Podocyte Dysfunction Induced by High Glucose, PMA, and MDP. [PDF]

J Cell Physiol
Kulesza T, Wróblewska A, Sawicka J, Audzeyenka I, Rachubik P, Rogacka D, Mallek W, Wysocka M, Lesner A, Piwkowska A.   +9 more
europepmc   +1 more source

A Glucose‐Responsive Intelligent Antibacterial and Oxygen‐Producing Hydrogel Promotes the Healing of Diabetic Wounds by Regulating Cellular Heterogeneity

Advanced Science, Volume 13, Issue 19, 2 April 2026.
We have developed a glucose‐triggered on‐demand drug delivery CF‐CPGaMPN hydrogel based on borate ester bonds. It inactivates microbes, releases oxygen, and enables on‐demand drug release in high‐glucose environments to promote healing of diabetic wounds. Single‐cell sequencing reveals that the CF‐CPGaMPN hydrogel significantly alleviates dysfunctional
Manxuan Liu, Zhongcheng Li, Qian Ren, Ziqian Lu, Yubing Zhang, Yili Guo, Ruomeng Li, Die Hu, Linglin Zhang   +8 more
wiley   +1 more source

Neutrophil Elastase Limits Spread of Staphylococcus aureus during Skin Infection. [PDF]

J Infect Dis
Kanoza M, Folkert J, Ciastoń I, Aliramezani A, Potempa J, Koziel J, Kwiecinski JM.   +6 more
europepmc   +1 more source

Neutrophil Elastase Modulates Cytokine Expression [PDF]

Journal of Biological Chemistry, 2012
Rym Benabid, Julien Wartelle, Laurette Malleret, Nicolas Guyot, Sophie Gangloff, François Lebargy, Azzaq Belaaouaj   +6 more
openaire   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, Volume 6, Issue 4, April 2026.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Research progress on the effect of neutrophil elastase and its inhibitors in respiratory diseases. [PDF]

J Int Med Res
Liang CC, Zhao J, Zhang YQ, Chen J, Wang Y.   +4 more
europepmc   +1 more source

Impaired Phagocytosis in Peritonitis Exudate Secondary to Complement Consumption [PDF]

, 1988
Billing, A., Fröhlich, D., Jochum, Marianne, Kortmann, H.   +3 more
core   +1 more source

Acute Invasive Pulmonary Aspergillosis With CNS Dissemination in an Immunocompetent Individual: A Case Report

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Invasive pulmonary aspergillosis can occur in patients without classical immunosuppression, particularly those with COPD and corticosteroid exposure. Early recognition, prompt antifungal therapy, and vigilance for neurological symptoms are essential to prevent central nervous system dissemination, which carries high mortality and significant ...
Barbare Khatiashvili, Sarah Saife, Islam Rajab, Malina Mohtadi, Arham Hazari, Ghassan Makhoul, Aqsa Zoey Sorathia, Ahmad Huzien, Shivanck Upadhyay   +8 more
wiley   +1 more source

Neutrophil elastase promotes mucin secretion in airway epithelial cells through the MARCKS/ACK1/cortactin pathway. [PDF]

Cent Eur J Immunol
He M, Li Q, Ouyang S, Liu Y, Perelman JM, Kolosov VP, Zhou X, Li Y.   +7 more
europepmc   +1 more source