Results 11 to 20 of about 57,341 (275)

Neutrophil elastase inhibitors [PDF]

Expert Opinion on Therapeutic Patents, 2011
Chronic obstructive pulmonary disease (COPD) constitutes a worldwide health problem. There is currently an urgent and unmet need for the development of small molecule therapeutics capable of blocking and/or reversing the progression of the disorder.
Groutas, William C., Dou, Dengfeng, Alliston, Kevin R.   +2 more
openaire   +3 more sources

Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia

Scientific Reports, 2021
Bacterial and viral respiratory infections can initiate acute lung injury and acute respiratory distress syndrome. Neutrophils and their granule enzymes, including neutrophil elastase, are key mediators of the pathophysiology of acute respiratory failure.
Hisanori Domon, Tomoki Maekawa, Toshihito Isono, Kazuyuki Furuta, Chikara Kaito, Yutaka Terao   +5 more
doaj   +1 more source

Phagocyte extracellular traps in children with neutrophilic airway inflammation

ERJ Open Research, 2021
Childhood lung infection is often associated with prominent neutrophilic airway inflammation and excess production of proteases such as neutrophil elastase (NE). The mechanisms responsible for this inflammation are not well understood.
Paul T. King, Lovisa Dousha, Nadeene Clarke, Jennifer Schaefer, Rosemary Carzino, Roleen Sharma, Ken L. Wan, Aveena Anantharajah, Kim O'Sullivan, Zhong X. Lu, Stephen R. Holdsworth, Sarath Ranganathan, Philip G. Bardin, David S. Armstrong   +13 more
doaj   +1 more source

Standardised Sonneratia apetala Buch.-Ham. fruit extract inhibits human neutrophil elastase and attenuates elastase-induced lung injury in mice

Frontiers in Pharmacology, 2022
Chronic obstructive pulmonary disease (COPD) along with asthma is a major and increasing global health problem. Smoking contributes to about 80%–90% of total COPD cases in the world.
Sayantan Sengupta, Nipun Abhinav, Sabita Singh, Sabita Singh, Joytri Dutta, Joytri Dutta, Ulaganathan Mabalirajan, Ulaganathan Mabalirajan, Karthigeyan Kaliyamurthy, Pulok Kumar Mukherjee, Parasuraman Jaisankar, Parasuraman Jaisankar, Arun Bandyopadhyay, Arun Bandyopadhyay   +13 more
doaj   +1 more source

The Role of Neutrophil Proteins on the Amyloid Beta-RAGE Axis. [PDF]

PLoS ONE, 2016
We previously showed an elevated expression of the neutrophil protein, cationic antimicrobial protein of 37kDa (CAP37), in brains of patients with Alzheimer's disease (AD), suggesting that CAP37 could be involved in AD pathogenesis.
Amanda J Stock, Anne Kasus-Jacobi, Jonathan D Wren, Virginie H Sjoelund, Glenn D Prestwich, H Anne Pereira   +5 more
doaj   +1 more source

Human Neutrophil Elastase Degrades SPLUNC1 and Impairs Airway Epithelial Defense against Bacteria [PDF]

, 2013
Background:Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a significant cause of mortality of COPD patients, and pose a huge burden on healthcare. One of the major causes of AECOPD is airway bacterial (e.g.
Bowler, RP, Chu, HW, Jiang, D, Schnell, C, Wenzel, SE, Wu, Q   +5 more
core   +6 more sources

Hemodialysis membrane-related neutrophil dysfunctions and pentoxifylline - a pilot study [PDF]

, 1990
Hemodialysis treatment is associated with activation of neutrophil granulocytes. Pentoxifylline has been shown to inhibit neutrophil activation in vitro and in vivo.
Hoffmann, H., Jochum, Marianne, Schiffl, H., Spannagl, Michael   +3 more
core   +1 more source

Clinical results of application of lymphotropic antibioticotherapy in patients with an acute pancreatitis

Український журнал клінічної хірургії, 2023
Objective.. To compare the clinical results of application of lymphotropic therapy and standard procedure of parenteral introduction of preparations. Materials and methods.
I. D. Duzhyi, O. L. Sytnik, G. I. Piatikop   +2 more
doaj   +1 more source

Visceral leishmaniasis patients display altered composition and maturity of neutrophils as well as impaired neutrophil effector functions [PDF]

, 2016
Immunologically, active visceral leishmaniasis (VL) is characterised by profound immunosuppression, severe systemic inflammatory responses and an impaired capacity to control parasite replication.
Adem, E, Cruz Cervera, E, Diro, E, Getahun, M, Hailu, A, Kropf, P, Lemma, M, Melkamu, R, Mengesha, B, Mesfin, G, Modolell, M, Muller, I, Munder, M, Skhedy, Z, Tajebe, F, Takele, Y, Van der Auwera, G, Yardley, V, Yeshanew, A, Yizengaw, E   +19 more
core   +3 more sources

Differential Inhibition of Human Neutrophil Elastase and Bacterial Elastase by endogenous Protease Inhibitors

Journal of Clinical and Biomedical Sciences, 2018
Human Neutrophil Elastase (HNE) is released from neutrophils when foreign substances are encoun-tered. Elastase is also released by invasive pathogenic microorganisms and is an important virulence factor.
Deena Mendez, Prasad SR, Kutty AVM
doaj   +1 more source