Results 21 to 30 of about 57,341 (275)
Solar ultraviolet irradiation induces decorin degradation in human skin likely via neutrophil elastase. [PDF]
PLoS ONE, 2013 Exposure of human skin to solar ultraviolet (UV) irradiation induces matrix metalloproteinase-1 (MMP-1) activity, which degrades type I collagen fibrils. Type I collagen is the most abundant protein in skin and constitutes the majority of skin connective
Yong Li +5 more
doaj +1 more source
Triterpenoids as Neutrophil Elastase Inhibitors [PDF]
Natural Product Communications, 2015 Neutrophile elastase has the capacity to degrade elastin, a protein found in the connective tissue of the lungs. Unchecked elastase leads to pulmonary pathologies. Therefore, the development of elastase inhibitors is currently actively pursued in the therapeutic field.
Dom, Guillaume +4 more
openaire +2 more sources
Mediators of Inflammation, 2010 Background. Inhaled antibiotics are commonly used in the treatment of cystic fibrosis lung disease. A previous study suggested neutrophil elastase activation by colistin in vitro.
Andreas Hector +2 more
doaj +1 more source
The Role of Neutrophils and Neutrophil Elastase in Pulmonary Arterial Hypertension
Frontiers in Medicine, 2018 Pulmonary arterial hypertension (PAH) is a severe vasculopathy characterized by the presence of fibrotic lesions in the arterial wall and the loss of small distal pulmonary arteries.
Shalina Taylor +7 more
doaj +1 more source
Earthworm coelomocyte extracellular traps : structural and functional similarities with neutrophil NETs [PDF]
, 2018 ROD UJ /
Joanna Homa
core +2 more sources
TRPV4-A Missing Link Between Mechanosensation and Immunity [PDF]
, 2020 Transient receptor potential vanilloid-type 4 (TRPV4) cation channel is widely expressed in all tissues as well as in immune cells and its function as mechanosensitive Ca2+ channel seems to be conserved throughout all mammalian species. Of late, emerging
Kuebler, Wolfgang M., Michalick, Laura
core +1 more source
Neutrophil elastase alters the murine gut microbiota resulting in enhanced Salmonella colonization. [PDF]
PLoS ONE, 2012 The intestinal microbiota has been found to play a central role in the colonization of Salmonella enterica serovar Typhimurium in the gastrointestinal tract.
Navkiran Gill +7 more
doaj +1 more source
The Natural Polypeptides as Significant Elastase Inhibitors
Frontiers in Pharmacology, 2020 Human neutrophil elastase (HNE) is a major cause of the destruction of tissues in cases of several different chronic andinflammatory diseases. Overexpression of the elastase enzyme plays a significant role in the pathogenesis of various diseases ...
Shabir Ahmad +10 more
doaj +1 more source
Flavonoids as inhibitors of human neutrophil elastase [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Elastase is a proteolytic enzyme belonging to the family of hydrolases produced by human neutrophils, monocytes, macrophages, and endothelial cells. Human neutrophil elastase is known to play multiple roles in the human body, but an increase in its activity may cause a variety of diseases.
Jakimiuk, Katarzyna +3 more
openaire +4 more sources
Східноукраїнський медичний журнал, 2020 Relevance. According to the WHO and the International Diabetes Federation (IDF), the number of patients with diabetes in the world reached 463 million people in 2019.
A. S. Nikolaienko
doaj +1 more source