Results 31 to 40 of about 57,341 (275)

Neutrophil-Associated Inflammatory Changes in the Pre-Diabetic Pancreas of Early-Age NOD Mice

Frontiers in Endocrinology, 2021
A growing body of evidence indicates that neutrophils are the first major leukocyte population accumulating inside the pancreas even before the onset of a lymphocytic-driven impairment of functional beta cells in type 1 diabetes mellitus (T1D). In humans,
Yesica Garciafigueroa, Brett E. Phillips, Carl Engman, Massimo Trucco, Massimo Trucco, Nick Giannoukakis, Nick Giannoukakis   +6 more
doaj   +1 more source

The Role of Neutrophils and Neutrophil Elastase in Pneumococcal Pneumonia [PDF]

Frontiers in Cellular and Infection Microbiology, 2021
Streptococcus pneumoniae, also known as pneumococcus, is a Gram-positive diplococcus and a major human pathogen. This bacterium is a leading cause of bacterial pneumonia, otitis media, meningitis, and septicemia, and is a major cause of morbidity and mortality worldwide. To date, studies onS.
Hisanori Domon, Hisanori Domon, Yutaka Terao, Yutaka Terao   +3 more
openaire   +3 more sources

Elevated serum neutrophil elastase is related to prehypertension and airflow limitation in obese women

BMC Women's Health, 2011
Background Neutrophil elastase level/activity is elevated in a variety of diseases such as atherosclerosis, systolic hypertension and obstructive pulmonary disease.
El-Baiomy Azza A, Zeidan Amany E, Mousa Amany A, El-Adawy Eman H, El-Eshmawy Mervat M, Abdel-Samie Elham R, Saleh Omayma M   +6 more
doaj   +1 more source

Discrimination of Methionine Sulfoxide and Sulfone by Human Neutrophil Elastase

Molecules, 2021
Human neutrophil elastase (HNE) is a uniquely destructive serine protease with the ability to unleash a wave of proteolytic activity by destroying the inhibitors of other proteases.
Darren Leahy, Cameron Grant, Alex Jackson, Alex Duff, Nicholas Tardiota, Jessica Van Haeften, Xingchen Chen, Jonathan M. Peake, Michael D. Kruppa, Eliot T. Smith, David A. Johnson, William B. Lott, Jonathan M. Harris   +12 more
doaj   +1 more source

Aprotinin reduces cardiac troponin I release and inhibits apoptosis of polymorphonuclear cells during off-pump coronary artery bypass surgery [PDF]

, 2008
Objectives: In addition to blood-sparing effects, aprotinin may have cardioprotective and anti-inflammatory effects during cardiopulmonary bypass-assisted cardiac surgery.
Bert, C., Ceuppens, J., De Buck, F., Delforge, M., Kasran, A., Meyns, B., Sergeant, P., Van Duppen, V., Van Hemelrijck, J., Wouters, Patrick   +9 more
core   +2 more sources

Activation of Proteinase 3 Contributes to Nonalcoholic Fatty Liver Disease and Insulin Resistance

Molecular Medicine, 2016
Activation of inflammatory pathways is known to accompany development of obesity-induced nonalcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes.
Erik J M Toonen, Andreea-Manuela Mirea, Cees J Tack, Rinke Stienstra, Dov B Ballak, Janna A van Diepen, Anneke Hijmans, Triantafyllos Chavakis, Wim H Dokter, Christine T N Pham, Mihai G Netea, Charles A Dinarello, Leo A B Joosten   +12 more
doaj   +1 more source

Serine protease inhibitor derived from Trichinella spiralis (TsSERP) inhibits neutrophil elastase and impairs human neutrophil functions

Frontiers in Cellular and Infection Microbiology, 2022
During early infection with Trichinella spiralis, host neutrophils destroy newborn larvae migrating in the bloodstream, preventing infection. However, parasites secrete various immunomodulatory molecules to escape the host’s defense mechanisms, allowing ...
Porntida Kobpornchai, Onrapak Reamtong, Orawan Phuphisut, Preeyarat Malaitong, Poom Adisakwattana   +4 more
doaj   +1 more source

Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection [PDF]

, 2015
Bioactive matrix fragments (matrikines) have been identified in a myriad of disorders, but their impact on the evolution of airway inflammation has not been demonstrated.
Snelgrove, RJ
core   +1 more source

Pathogenesis of chronic obstructive pulmonary disease [PDF]

, 2005
The current paradigm for the pathogenesis of chronic obstructive pulmonary disease is that chronic airflow limitation results from an abnormal inflammatory response to inhaled particles and gases in the lung. Airspace inflammation appears to be different
Macnee, W
core   +2 more sources

Neutrophil elastase in the tumor microenvironment [PDF]

Steroids, 2018
Myeloid cell production within the bone marrow is accelerated in the setting of cancer, and the numbers of circulating and infiltrating neutrophils and granulocytic myeloid derived suppressor cells (MDSCs) correlate with tumor progression and patient survival.
Irina, Lerman, Stephen R, Hammes
openaire   +2 more sources