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Clinical & Translational Immunology, 2022 Objectives Immune thrombocytopenia (ITP) is an autoimmune disease characterised by impaired platelet production and increased platelet destruction. However, the involvement of neutrophils in ITP is yet to be explored.
Pengcheng Xu +12 more
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Frontiers in Medicine, 2022 Transfusion of granulocyte concentrates (GC) is an alternative therapy for neutropenic patients with life-threatening infections. While neutrophils are the main source of antimicrobial activity, only neutrophil numbers are used to certify GCs.
Andréa Murru +19 more
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The Role of Neutrophils and Neutrophil Elastase in Pneumococcal Pneumonia [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Streptococcus pneumoniae, also known as pneumococcus, is a Gram-positive diplococcus and a major human pathogen. This bacterium is a leading cause of bacterial pneumonia, otitis media, meningitis, and septicemia, and is a major cause of morbidity and mortality worldwide. To date, studies onS.
Hisanori Domon +3 more
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Neutrophils Kill Reactive Oxygen Species-Resistant Pseudomonas aeruginosa by Sphingosine
Cellular Physiology and Biochemistry, 2017 Background/Aims: Cystic fibrosis (CF) is dominated by chronic inflammation and infection of the lung resulting in lung destruction and early death of patients. The lungs of CF patients are characterized by a massive accumulation of neutrophils.
Katrin Anne Becker +9 more
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Cell Cycle, 2015 Neutrophils are short-lived effector cells of the innate immune system that form the first line of defense against microbial pathogens.1 Recent studies show that, by migrating to bone marrow, these cells can also induce (VACV)-specific T cell responses.2 Neutrophils polarize to distinct phenotypes in response to environmental cytokine/chemokine signals.
Mariano Esteban, Mauro Di Pilato
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ERJ Open Research, 2015 In the airways of severe asthmatics, an increase of neutrophils and eosinophils is often observed despite high-dose corticosteroid therapy. We previously reported that interleukin-8-stimulated neutrophils induced trans-basement membrane migration (TBM ...
Fuyumi Nishihara +7 more
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Characterization of Neutrophil Function in Human Cutaneous Leishmaniasis Caused by Leishmania braziliensis. [PDF]
PLoS Neglected Tropical Diseases, 2016 Infection with different Leishmania spp. protozoa can lead to a variety of clinical syndromes associated in many cases with inflammatory responses in the skin.
Jacilara Conceição +7 more
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Circulation Research, 2015 More than a century ago, in 1881, Bizzozero1 discovered platelets and their role in primary hemostasis. Since this founding study, it has been shown that, in addition to the scaffold of platelets and fibrin, other proteins and cells play an important role in thrombus formation and stabilization.
Benoît Ho-Tin-Noé +1 more
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Frontiers in Immunology, 2021 Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that neutrophils play an important role in the pathophysiology, particularly in those with severe disease courses.
Nico Reusch +16 more
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Immunoreceptors on neutrophils
Seminars in Immunology, 2016 Neutrophils play a critical role in the host defense against infection, and they are able to perform a variety of effector mechanisms for this purpose. However, there are also a number of pathological conditions, including autoimmunity and cancer, in which the activities of neutrophils can be harmful to the host. Thus the activities of neutrophils need
van Rees, Dieke J +4 more
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