Results 11 to 20 of about 32,351 (183)

Predictors of HIV Vertical Transmission in Exposed Infants in Northwest, Ethiopia: A Retrospective Cohort Study. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Although the global plan aimed to eliminate mother‐to‐child transmission of HIV by 2015, an estimated 130,000 children were newly infected, and 84,000 children died from HIV related causes in 2022. In Ethiopia, 3200 children became newly infected and 1,900 children died from HIV related causes in 2022.
Ejigu AG, Degu T, Ahmed AF, Temesgen A, Yeshiwas AG, Kebede AM, Bayeh GM, Yenew C, Gebeyehu AA, Alemu BW, Yigzaw ZA, Mekonen H, Bogale TW, Anteneh RM, Enawgaw AS, Yirdaw G, Desalegn RB, Mekonnen BA, Alemayehu MA, Tsega SS.   +19 more
europepmc   +2 more sources

A Riboflavin-Derived Flavinium Salt Mediates Chemoselective Methylation Reactions. [PDF]

Chemistry
A two‐component methylation protocol was developed, where the active flavin mediator can be recycled in a single step. Crystallographic data and NMR spectroscopy support the mechanistic proposal, while chemoselective methylation was observed for a broad range of biologically relevant substrates. ABSTRACT Selective methylation is among the most relevant
Langschwager T, Suylu E, Zuber J, Storch G.   +3 more
europepmc   +2 more sources

Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals. [PDF]

, 2007
BackgroundThe SCID-hu Thy/Liv mouse model of HIV-1 infection is a useful platform for the preclinical evaluation of antiviral efficacy in vivo.
A Adachi, A Valentin, April N. Kinkade, Barbara Sloan, BD Jamieson, BD Jamieson, BK Berges, BS Robinson, CA Stoddart, CA Stoddart, CA Stoddart, Cheryl A. Bales, Cheryl A. Stoddart, E De Clercq, ED Miller, EJ Freireich, ES Withers-Ward, G Kovalev, George Chkhenkeli, GM Aldrovandi, GM Aldrovandi, GM Aldrovandi, H Kaneshima, H Kaneshima, J McCune, J Mordenti, Jennifer C. Bare, JF Krowka, JM McCune, JM McCune, JM McCune, JM McCune, JM Strizki, José M. Rivera, JY Feng, L Rabin, L Su, L Su, L Zhang, Linqi Zhang, LT Rimsky, M Markowitz, Mary E. Moreno, ME Keir, MG Manz, ML Bonyhadi, ML Greenberg, Paul L. Black, PS Koka, R Datema, R Namikawa, R Namikawa, RC Bast, RD Berkowitz, RD Berkowitz, RD Berkowitz, RD Berkowitz, RG Amado, Rollie E. Ronquillo, S Baenziger, S Gartner, S Gorantla, SD Young, SG Kitchen, SG Kitchen, SK Stanley, Sofiya A. Galkina, Z Sun   +67 more
core   +12 more sources

Nevirapine versus Efavirenz for patients co-infected with HIV and Tuberculosis: A Randomised Non-Inferiority Trial [PDF]

, 2013
BACKGROUND: In countries with a high incidence of HIV and tuberculosis co-infection, nevirapine and efavirenz are widely used as antiretroviral therapy but both interact with antituberculosis drugs. We aimed to compare efficacy and safety of a nevirapine-
Agnès Sobry, Alexandra Calmy, Anne-Marie Taburet, Avihingsanon, Blackwelder, Boulle, Carlota Silva, Chen, Christine Rouzioux, Christophe Michon, Cohen, Cohen, Davies, Dejesus, Dieterich, Elisabeth Baudin, Elizabete Nunes, Flandre, Ford, Gengiah, Gulick, Ilesh Jani, Kwara, Laura Ciaffi, Maartens, Manosuthi, Manosuthi, Maryline Bonnet, Matteelli, Mbuagbaw, Meintjes, Nilesh Bhatt, Rui Bastos, Scourfield, Shipton, Soriano, Swaminathan, Tang, Telenti, van Leth   +39 more
core   +3 more sources

HIV-positive nigerian adults harbor significantly higher serum lumefantrine levels than HIV-negative individuals seven days after treatment for Plasmodium falciparum infection. [PDF]

, 2013
Management of coinfection with malaria and HIV is a major challenge to public health in developing countries, and yet potential drug-drug interactions between antimalarial and antiviral regimens have not been adequately investigated in people with both ...
Albert van Wyk, Back, Beshir, Blessborn, Bousema, Byakika-Kibwika, Chijioke Nwauche, Colin J. Sutherland, Dinko, Djimde, Djimdé, Dlamini, Ezzet, Ezzet, Federal Ministry of Health Nigeria, Gerber, Harparkash Kaur, Havlir, Humphreys, Ifeyinwa Chijioke-Nwauche, Khalid B. Beshir, Khoo, Korenromp, Kredo, Lefèvre, McGready, Nwauche, Salman, Sutherland, van Vugt, Whitworth   +30 more
core   +1 more source

Microbicides development programme: engaging the community in the standard of care debate in a vaginal microbicide trial in Mwanza, Tanzania. [PDF]

, 2009
BACKGROUND: HIV prevention research in resource-limited countries is associated with a variety of ethical dilemmas. Key amongst these is the question of what constitutes an appropriate standard of health care (SoC) for participants in HIV prevention ...
Changalucha, John, Hayes, Richard J, Kazimoto, Johari, Lees, Shelley, Masanja, Joseph, McCormack, Sheena, Moffat, Claire, Nikolau, Lawi, Shagi, Charles, Shapiro, Katherine, Soteli, Selephina, Vallely, Andrew   +11 more
core   +2 more sources

High acceptability of voluntary counselling and HIV-testing but unacceptable loss to follow up in a prevention of mother-to-child HIV transmission programme in rural Malawi: scaling-up requires a different way of acting. [PDF]

, 2005
SETTING: Thyolo District Hospital, rural Malawi. OBJECTIVES: In a prevention of mother-to-child HIV transmission (PMTCT) programme, to determine: the acceptability of offering 'opt-out' voluntary counselling and HIV-testing (VCT); the progressive loss to
Brahmbhatt, Bulterys, Caballero-Gordo, Graham, Graham, Green, Guay, Isenalumbe, MOHP, MOHP, MOHP, MOHP, Newell, Nolan, NSO, Stringer, Sweat, Taha, Taha, UNAIDS/WHO, VCT group, Walraven, WHO, WHO/UNAIDS, World Health Organization (WHO), Zachariah, Zachariah   +26 more
core   +2 more sources

Evaluation of a 5-year programme to prevent mother-to-child transmission of HIV infection in Northern Uganda [PDF]

, 2010
Prevention of mother-to-child transmission (PMTCT) is essential in HIV/AIDS control. We analysed 2000-05 data from mother-infant pairs in our PMTCT programme in rural Uganda, examining programme utilization and outcomes, HIV transmission rates and ...
Ahoua, Laurence, Ayikoru, Harriet, Balkan, Suna, Gnauck, Katherine, Odar, Emmanuel, Odaru, Grace, Olson, David, Ondoa-Onama, Christine, Pinoges, Loretxu, Pujades-Rodríguez, Mar   +9 more
core   +2 more sources

Nevirapine Increases Sodium/Iodide Symporter-Mediated Radioiodide Uptake by Activation of TSHR/cAMP/CREB/PAX8 Signaling Pathway in Dedifferentiated Thyroid Cancer

Frontiers in Oncology, 2020
Nevirapine has been proved to be effective in inducing re-differentiation and suppressing tumor growth in several tumor cells. This study aims to investigate the therapeutic potential of nevirapine in dedifferentiated thyroid cancer (DeTC), which ...
Hongxia Shang, Junyu Zhao, Junyu Zhao, Jinming Yao, Huanjun Wang, Jianjun Dong, Lin Liao, Lin Liao   +7 more
doaj   +1 more source

Nevirapine- and efavirenz-associated hepatotoxicity under programmatic conditions in Kenya and Mozambique. [PDF]

, 2012
To describe the frequency, risk factors, and clinical signs and symptoms associated with hepatotoxicity (HT) in patients on nevirapine- or efavirenz-based antiretroviral therapy (ART), we conducted a retrospective cohort analysis of patients attending ...
Biot, M, Chu, K M, Ford, N P, Manzi, M, Rasschaert, F, Zachariah, R, Zuniga, I   +6 more
core   +2 more sources