Results 31 to 40 of about 23,399,129 (120)
Highly Pathogenic New World Arenavirus Infection Activates the Pattern Recognition Receptor Protein Kinase R without Attenuating Virus Replication in Human Cells [PDF]
Journal of Virology, 2017 ABSTRACT The arenavirus family consists of several highly pathogenic viruses, including the Old World (OW) arenavirus Lassa fever virus (LASV) and the New World (NW) Junin virus (JUNV) and Machupo virus (MACV). Host response to infection by these pathogenic arenaviruses is distinct in many aspects.
Cheng, Huang +4 more
openaire +2 more sources
Novel Oliveros-like Clade C Mammarenaviruses from Rodents in Argentina, 1990–2020
VirusesFollowing an Argentine Hemorrhagic Fever (AHF) outbreak in the early 1990s, a rodent survey for Junín virus, a New World Clade B arenavirus, in endemic areas of Argentina was conducted.
Elizabeth Shedroff +12 more
doaj +1 more source
Viruses, 2018 New World arenaviruses cause fatal hemorrhagic disease in South America. Pirital virus (PIRV), a mammarenavirus hosted by Alston’s cotton rat (Sigmodon alstoni), causes a disease in Syrian golden hamsters (Mesocricetus auratus) (biosafety level-3 ...
Corey L. Campbell +7 more
doaj +1 more source
The New World arenavirus Tacaribe virus induces caspase-dependent apoptosis in infected cells
Journal of General Virology, 2016 The Arenaviridae is a diverse and growing family of viruses that already includes more than 25 distinct species. While some of these viruses have a significant impact on public health, others appear to be non-pathogenic. At present little is known about the host cell responses to infection with different arenaviruses, particularly those found in the ...
Wolff, Svenja +6 more
openaire +4 more sources
Potent inhibition of Junín virus infection by interferon in murine cells. [PDF]
PLoS Neglected Tropical Diseases, 2014 The new world arenavirus Junín virus (JUNV) is the causative agent of Argentine hemorrhagic fever, a lethal human infectious disease. Adult laboratory mice are generally resistant to peripheral infection by JUNV.
Cheng Huang +6 more
doaj +1 more source
Molecular organization of the New World arenavirus spike glycoprotein complex
Nature MicrobiologyAbstract Of the multiple arenaviruses that cause haemorrhagic fevers in the Americas, all lack reliable therapeutic options, and only one has a vaccine. The arenavirus glycoprotein complex (GPC) binds cellular receptors and mediates pH-dependent fusion of viral and host cell membranes during entry.
Colin J. Mann +8 more
openaire +2 more sources
PLoS Neglected Tropical Diseases, 2023 Numerous arenaviruses have been identified throughout the Americas and a subset of these viruses cause viral hemorrhagic fever in humans. This study compared the pathology and viral RNA distribution in Hartley guinea pigs challenged with two human ...
Curtis Cline +10 more
doaj +1 more source
South American Hemorrhagic Fevers: A summary for clinicians
International Journal of Infectious Diseases, 2021 Objectives: This article is one of a series on acute, severe diseases of humans caused by emerging viruses for which there are no or limited licensed medical countermeasures.
Maria G. Frank +22 more
doaj +1 more source
Scientific Reports, 2017 Machupo virus (MACV) is a New World (NW) arenavirus and causative agent of Bolivian hemorrhagic fever (HF). Here, we identified a variant of MACV strain Carvallo termed Car91 that was attenuated in guinea pigs.
Joseph W. Golden +6 more
doaj +1 more source
Tacaribe virus but not junin virus infection induces cytokine release from primary human monocytes and macrophages. [PDF]
PLoS Neglected Tropical Diseases, 2011 The mechanisms underlying the development of disease during arenavirus infection are poorly understood. However, common to all hemorrhagic fever diseases is the involvement of macrophages as primary target cells, suggesting that the immune response in ...
Allison Groseth +6 more
doaj +1 more source