Results 21 to 30 of about 23,399,129 (120)

Machupo virus glycoprotein determinants for human transferrin receptor 1 binding and cell entry. [PDF]

PLoS ONE, 2011
Machupo virus (MACV) is a highly pathogenic New World arenavirus that causes hemorrhagic fever in humans. MACV, as well as other pathogenic New World arenaviruses, enter cells after their GP1 attachment glycoprotein binds to their cellular receptor ...
Sheli R Radoshitzky, Lindsay E Longobardi, Jens H Kuhn, Cary Retterer, Lian Dong, Jeremiah C Clester, Krishna Kota, John Carra, Sina Bavari   +8 more
doaj   +1 more source

Comparative analysis of disease pathogenesis and molecular mechanisms of New World and Old World arenavirus infections

Journal of General Virology, 2014
Arenaviruses can cause fatal human haemorrhagic fever (HF) diseases for which vaccines and therapies are extremely limited. Both the New World (NW) and Old World (OW) groups of arenaviruses contain HF-causing pathogens. Although these two groups share many similarities, important differences with regard to pathogenicity and molecular mechanisms of ...
Lisa, McLay, Yuying, Liang, Hinh, Ly
openaire   +2 more sources

Single Nucleoprotein Residue Modulates Arenavirus Replication Complex Formation

mBio, 2015
The Arenaviridae are enveloped, negative-sense RNA viruses with several family members that cause hemorrhagic fevers. This work provides immunofluorescence evidence that, unlike those of New World arenaviruses, the replication and transcription complexes
Kristeene A. Knopp, Tuan Ngo, Paul D. Gershon, Michael J. Buchmeier   +3 more
doaj   +1 more source

New World Arenavirus Clade C, but Not Clade A and B Viruses, Utilizes α-Dystroglycan as Its Major Receptor [PDF]

Journal of Virology, 2002
ABSTRACT α-Dystroglycan (α-DG) has been identified as a major receptor for lymphocytic choriomeningitis virus (LCMV) and Lassa virus, two Old World arenaviruses. The situation with New World arenaviruses is less clear: previous studies demonstrated that Oliveros virus also exhibited high-affinity binding to α-DG but that Guanarito virus did ...
Christina F, Spiropoulou, Stefan, Kunz, Pierre E, Rollin, Kevin P, Campbell, Michael B A, Oldstone   +4 more
openaire   +2 more sources

Visualization of Double-Stranded RNA Colocalizing With Pattern Recognition Receptors in Arenavirus Infected Cells

Frontiers in Cellular and Infection Microbiology, 2018
An important step in the initiation of the innate immune response to virus infection is the recognition of non-self, viral RNA, including double-stranded RNA (dsRNA), by cytoplasmic pattern recognition receptors (PRRs).
Elizabeth J. Mateer, Slobodan Paessler, Cheng Huang   +2 more
doaj   +1 more source

Chapare virus, a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in Bolivia. [PDF]

PLoS Pathogens, 2008
A small focus of hemorrhagic fever (HF) cases occurred near Cochabamba, Bolivia, in December 2003 and January 2004. Specimens were available from only one fatal case, which had a clinical course that included fever, headache, arthralgia, myalgia, and ...
Simon Delgado, Bobbie R Erickson, Roberto Agudo, Patrick J Blair, Efrain Vallejo, César G Albariño, Jorge Vargas, James A Comer, Pierre E Rollin, Thomas G Ksiazek, James G Olson, Stuart T Nichol   +11 more
doaj   +1 more source

A multivalent and cross-protective vaccine strategy against arenaviruses associated with human disease.

PLoS Pathogens, 2009
Arenaviruses are the causative pathogens of severe hemorrhagic fever and aseptic meningitis in humans, for which no licensed vaccines are currently available. Pathogen heterogeneity within the Arenaviridae family poses a significant challenge for vaccine
Maya F Kotturi, Jason Botten, John Sidney, Huynh-Hoa Bui, Lori Giancola, Matt Maybeno, Josie Babin, Carla Oseroff, Valerie Pasquetto, Jason A Greenbaum, Bjoern Peters, Joey Ting, Danh Do, Lo Vang, Jeff Alexander, Howard Grey, Michael J Buchmeier, Alessandro Sette   +17 more
doaj   +1 more source

World Development Indicators 2011 [PDF]

, 2011
World development indicators 2011, the 15th edition in its current format, aims to provide relevant, high-quality, internationally comparable statistics about development and the quality of people's ...
World Bank
core   +1 more source

Interaction of silver nanoparticles with Tacaribe virus

Journal of Nanobiotechnology, 2010
Background Silver nanoparticles possess many unique properties that make them attractive for use in biological applications. Recently they received attention when it was shown that 10 nm silver nanoparticles were bactericidal, which is promising in light
Speshock Janice L, Murdock Richard C, Braydich-Stolle Laura K, Schrand Amanda M, Hussain Saber M   +4 more
doaj   +1 more source

The Z Protein of the New World Arenavirus Tacaribe Virus Has Bona Fide Budding Activity That Does Not Depend on Known Late Domain Motifs [PDF]

Journal of Virology, 2009
ABSTRACT The arenavirus small RING finger Z protein has been shown to be the main driving force of budding for several arenaviruses. This Z budding activity was found to be mediated by the late (L)-domain motifs P(T/S)AP and PPXY, located at the C terminus of Z. Here, we show that the Z protein of Tacaribe virus (TACV), a New World arenavirus,
Shuzo, Urata, Jiro, Yasuda, Juan Carlos, de la Torre   +2 more
openaire   +2 more sources