Results 1 to 10 of about 100 (90)
mBio, 2022 Transmission of the New World hemorrhagic fever arenaviruses Junín virus (JUNV) and Machupo virus (MACV) to humans is facilitated, in part, by the interaction between the arenavirus GP1 glycoprotein and the human transferrin receptor 1 (hTfR1).
Weng M. Ng +9 more
doaj +4 more sources
TRIM2, a novel member of the antiviral family, limits New World arenavirus entry.
PLoS Biology, 2019 Tripartite motif (TRIM) proteins belong to a large family with many roles in host biology, including restricting virus infection. Here, we found that TRIM2, which has been implicated in cases of Charcot-Marie-Tooth disease (CMTD) in humans, acts by ...
Nicolas Sarute +9 more
doaj +6 more sources
The board is set, the pieces are moving: Modulation of New World arenavirus entry by host proteins.
PLoS Pathogens, 2021 Nicolás Sarute, Susan R Ross
doaj +6 more sources
CACNA1S haploinsufficiency confers resistance to New World arenavirus infection [PDF]
Proceedings of the National Academy of Sciences, 2020 Significance It is well known that genetic differences among individuals can influence their susceptibility to infectious disease. Our results, using New World arenavirus-infected mice heterozygous for the α1S chain of the VGCC, human cells heterozygous for a mutation of this chain, and drugs that target this receptor, highlight the ...
Nicolás Sarute, Susan R. Ross
openaire +2 more sources
Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa. [PDF]
PLoS Pathogens, 2009 Lujo virus (LUJV), a new member of the family Arenaviridae and the first hemorrhagic fever-associated arenavirus from the Old World discovered in three decades, was isolated in South Africa during an outbreak of human disease characterized by nosocomial ...
Thomas Briese +11 more
doaj +1 more source
Activity of a Phenolic Dibenzylsulfide against New World Arenavirus Infections [PDF]
Antiviral Chemistry and Chemotherapy, 2014 Background: Junín virus (JUNV) and several other clade B New World arenaviruses cause human disease ranging from mild febrile illness to severe viral haemorrhagic fever. These viruses pose a significant threat to national security and safe and effective therapies are limited except in Argentina, where immune plasma is the standard of care for treating ...
Brian B, Gowen +5 more
openaire +2 more sources
The late endosome-resident lipid bis(monoacylglycero)phosphate is a cofactor for Lassa virus fusion.
PLoS Pathogens, 2021 Arenavirus entry into host cells occurs through a low pH-dependent fusion with late endosomes that is mediated by the viral glycoprotein complex (GPC). The mechanisms of GPC-mediated membrane fusion and of virus targeting to late endosomes are not well ...
Ruben M Markosyan +4 more
doaj +1 more source
Junin Virus Activates p38 MAPK and HSP27 Upon Entry
Frontiers in Cellular and Infection Microbiology, 2022 Junín virus (JUNV), a New World arenavirus, is a rodent-borne virus and the causative agent of Argentine hemorrhagic fever. Humans become infected through exposure to rodent host secreta and excreta and the resulting infection can lead to an acute ...
Collin J. Fitzpatrick +11 more
doaj +1 more source
Fatal illnesses associated with a new world arenavirus--California, 1999-2000. [PDF]
MMWR. Morbidity and mortality weekly report, 2000 The California Department of Health Services (CDHS) and the University of Texas Medical Branch (UTMB) recently identified evidence of infection with an arenavirus in three patients hospitalized with similar fatal illnesses. This report summarizes the investigation of these cases.
+5 more sources
Sabiá Virus–Like Mammarenavirus in Patient with Fatal Hemorrhagic Fever, Brazil, 2020
Emerging Infectious Diseases, 2020 New World arenaviruses can cause chronic infection in rodents and hemorrhagic fever in humans. We identified a Sabiá virus–like mammarenavirus in a patient with fatal hemorrhagic fever from São Paulo, Brazil.
Fernanda de Mello Malta +13 more
doaj +1 more source