Results 1 to 10 of about 456,853 (317)

The protective activity of natural flavonoids against osteoarthritis by targeting NF-κB signaling pathway

Frontiers in Endocrinology, 2023
Osteoarthritis (OA) is a typical joint disease associated with chronic inflammation. The nuclear factor-kappaB (NF-κB) pathway plays an important role in inflammatory activity and inhibiting NF-κB-mediated inflammation can be a potential strategy for ...
Yongjun Ye, Jianguo Zhou
doaj   +2 more sources

Effects of the NF-κB Signaling Pathway Inhibitor BAY11-7082 in the Replication of ASFV

Viruses, 2022
African swine fever virus (ASFV) mainly infects the monocyte/macrophage lineage of pigs and regulates the production of cytokines that influence host immune responses. Several studies have reported changes in cytokine production after infection with ASFV,
Qi Gao, Yunlong Yang, Yongzhi Feng, Weipeng Quan, Yizhuo Luo, Heng Wang, Jiachen Zheng, Xiongnan Chen, Zhao Huang, Xiaojun Chen, Runda Xu, Guihong Zhang, Lang Gong   +12 more
doaj   +2 more sources

NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1 [PDF]

Viruses, 2013
The principal Epstein-Barr virus (EBV) oncoprotein, Latent Membrane Protein 1 (LMP1), is expressed in most EBV-associated human malignancies. LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive NF-κB, MAP kinase, IRF7, and PI3
Benjamin E. Gewurz, Ina Ersing, Katharina Bernhardt   +2 more
doaj   +6 more sources

Inhibition of NF-κB Signaling Pathway by Resveratrol Improves Spinal Cord Injury

Frontiers in Neuroscience, 2018
Spinal cord injury (SCI) can have a significant impact on an individual’s life. Herein, we discuss how resveratrol improves SCI by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway.
Luyao Xu, Benson O. A. Botchway, Songou Zhang, Jingying Zhou, Xuehong Liu   +4 more
doaj   +2 more sources

LPAR1 Promotes Activation of Pathways Alveolar Hypercoagulation and Fibrinolytic Inhibition in ARDS via NF‐κB Signaling Pathway [PDF]

FASEB BioAdvances
Alveolar hypercoagulation and fibrinolytic inhibition are critical mechanisms contributing to refractory hypoxemia in acute respiratory distress syndrome (ARDS).
Ying Liu, Xianjun Chen, Meng Liu, Jia Yuan, Qing Li, Lu Li, Qi Dong, Junling Tao, Feng Shen, Chuan Xiao   +9 more
doaj   +2 more sources

Quercetin improves cerebral ischemia/reperfusion injury by promoting microglia/macrophages M2 polarization via regulating PI3K/Akt/NF-κB signaling pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023
The modulation of microglial polarization from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype shows promise as a therapeutic strategy for ischemic stroke.
Lin Li, Weifeng Jiang, Baojian Yu, Huiqi Liang, Shihui Mao, Xiaowei Hu, Yan Feng, Jiadong Xu, Lisheng Chu   +8 more
semanticscholar   +1 more source

cGMP signaling pathway that modulates NF-κB activation in innate immune responses

iScience, 2021
Summary: The nuclear factor-kappa B (NF-κB) pathway is an evolutionarily conserved signaling pathway that plays a central role in immune responses and inflammation. Here, we show that Drosophila NF-κB signaling is activated via a pathway in parallel with
Hirotaka Kanoh, Shinzo Iwashita, Takayuki Kuraishi, Akira Goto, Naoyuki Fuse, Haruna Ueno, Mariko Nimura, Tomohito Oyama, Chang Tang, Ryo Watanabe, Aki Hori, Yoshiki Momiuchi, Hiroki Ishikawa, Hiroaki Suzuki, Kumiko Nabe, Takeshi Takagaki, Masataka Fukuzaki, Li-Li Tong, Sinya Yamada, Yoshiteru Oshima, Toshiro Aigaki, Julian A.T. Dow, Shireen-Anne Davies, Shoichiro Kurata   +23 more
doaj   +1 more source

Pharmacological Effects of Polyphenol Phytochemicals on the Intestinal Inflammation via Targeting TLR4/NF-κB Signaling Pathway

International Journal of Molecular Sciences, 2022
TLR4/NF-κB is a key inflammatory signaling transduction pathway, closely involved in cell differentiation, proliferation, apoptosis, and pro-inflammatory response.
Caiyun Yu, D. Wang, Zaibin Yang, Tian Wang   +3 more
semanticscholar   +1 more source

STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway

Cell Death and Disease, 2021
Damaged deoxyribonucleic acid (DNA) is a primary pathologic factor for osteoarthritis (OA); however, the mechanism by which DNA damage drives OA is unclear.
Qiang Guo, Ximiao Chen, Jiaoxiang Chen, Gang Zheng, Chenglong Xie, Hongqiang Wu, Zhimin Miao, Yan Lin, Xiangyang Wang, Weiyang Gao, Xiangtao Zheng, Zongyou Pan, Yifei Zhou, Yaosen Wu, Xiaolei Zhang   +14 more
semanticscholar   +1 more source

Progress and Prospects of Non-Canonical NF-κB Signaling Pathway in the Regulation of Liver Diseases

Molecules, 2022
Non-canonical nuclear factor kappa B (NF-κB) signaling pathway regulates many physiological and pathological processes, including liver homeostasis and diseases.
Li Tao, Xiaomeng Ren, Wenhui Zhai, Zheng Chen   +3 more
doaj   +1 more source