Results 21 to 30 of about 456,853 (317)

Inhibition of BET Protein Function Suppressed the Overactivation of the Canonical NF-κB Signaling Pathway in 6-OHDA-Lesioned Rat Model of Levodopa-Induced Dyskinesia

Frontiers in Neuroscience, 2022
BackgroundNeuroinflammation is involved in the mechanisms of levodopa-induced dyskinesia (LID). The canonical NF-κB activation signaling pathway plays a critical role in the neuroinflammation development and BET protein-induced NF-κB-mediated ...
Ying Wan, Li Han, Lu Rong, Shuyuan Yang, Lu Song, Na Wu, Zhenguo Liu, Jing Gan   +7 more
doaj   +1 more source

IRF3 and IRF8 Regulate NF-κB Signaling by Targeting MyD88 in Teleost Fish

Frontiers in Immunology, 2020
MyD88 is a conserved intracellular adaptor, which plays an important role in the innate immune system. MyD88 transmits signals for downstream of toll-like and IL-1 receptors to activate NF-κB signaling pathway, which is tightly controlled in the immune ...
Xiaolong Yan, Xiaolong Yan, Xueyan Zhao, Ruixuan Huo, Tianjun Xu, Tianjun Xu, Tianjun Xu, Tianjun Xu, Tianjun Xu   +8 more
doaj   +1 more source

Effect of canonical NF-κB signaling pathway on the differentiation of rat dental epithelial stem cells

Stem Cell Research & Therapy, 2019
Background Nuclear factor-κB (NF-κB), an important transcription factor, participates in many physiological and pathological processes such as growth, differentiation, organogenesis, apoptosis, inflammation, and immune response, including tooth ...
Yan Liang, Guoqing Chen, Yuzhi Yang, Ziyue Li, Tian Chen, Wenhua Sun, Mei Yu, Kuangwu Pan, Weihua Guo, Weidong Tian   +9 more
doaj   +1 more source

Acupuncture Attenuates Inflammation in Microglia of Vascular Dementia Rats by Inhibiting miR-93-Mediated TLR4/MyD88/NF-κB Signaling Pathway

Oxidative Medicine and Cellular Longevity, 2020
Background It is widely accepted that inflammation may contribute to cognitive impairment in patients with vascular dementia (VD). Our prior clinical researches have reported that acupuncture can alleviate cognitive function in VD, but the underlying ...
Lu Wang, Jing-Wen Yang, Li-Ting Lin, Jin Huang, Xuerui Wang, Xin-Tong Su, Yan Cao, M. Fisher, Cun-Zhi Liu   +8 more
semanticscholar   +1 more source

Research progress of NF-κB signaling pathway and thrombosis

Frontiers in Immunology, 2023
Venous thromboembolism is a very common and costly health problem. Deep-vein thrombosis (DVT) can cause permanent damage to the venous system and lead to swelling, ulceration, gangrene, and other symptoms in the affected limb. In addition, more than half
Z. Wang, Chucun Fang, Mengting Yao, Dongwen Wu, Maga Chen, Tianting Guo, Jianwen Mo   +6 more
semanticscholar   +1 more source

Anaplasma phagocytophilum Activates NF-κB Signaling via Redundant Pathways

Frontiers in Public Health, 2020
Anaplasma phagocytophilum subverts neutrophil function permitting intracellular survival, propagation and transmission. Sustained pro-inflammatory response, recruitment of new host cells for population expansion, and delayed apoptosis are associated with
J. Stephen Dumler, J. Stephen Dumler, Marguerite Lichay, Wan-Hsin Chen, Kristen E. Rennoll-Bankert, Jin-ho Park   +5 more
doaj   +1 more source

WITHDRAWN: Inhibition of CHOP weakens the promotion of chronic intermittent hypoxia on epithelial cells apoptosis via inhibiting PI3K-Akt and NF-κB signaling pathways

Oncotarget, 2017
// Yi-Bin Wang 1, * , Yin Ni 2, * , Ren-Hua Sun 2 , Xiao-Zhou Mou 3 , Fang Han 2 , Qian Li 2 , Hai-Jun Huang 4 , Jing-Quan Liu 2 and Yue-Xing Tu 2 1 Department of Cardiology, Chun’an First People’s Hospital, Zhejiang Provincial People’s Hospital Chun’an Branch, Hangzhou, Zhejiang 311700, China 2 Department of Critical Care Medicine ...
Yi-Bin Wang, Yi-Bin Wang, Yin Ni, Yin Ni, Ren-Hua Sun, Ren-Hua Sun, Xiao-Zhou Mou, Xiao-Zhou Mou, Fang Han, Fang Han, Qian Li, Qian Li, Hai-Jun Huang, Hai-Jun Huang, Jing-Quan Liu, Jing-Quan Liu, Yue-Xing Tu, Yue-Xing Tu   +17 more
openaire   +1 more source

Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity [PDF]

, 2015
The nuclear factor κB (NF-κB) pathway is a master regulator of inflammatory processes and is implicated in insulin resistance and pancreatic β cell dysfunction in the metabolic syndrome.
Brink, Robert, Cantley, James, Grey, Shane T., Hesselson, Daniel, Koay, Yen Chin, Loudovaris, Tom, Malle, Elisabeth K., McAlpine, Shelli R., Tan, Bernice M., Villanueva, Jeanette E., Walters, Stacey N., Wu, Jianmin, Zammit, Nathan W.   +12 more
core   +4 more sources

Macrophage SCAP Contributes to Metaflammation and Lean NAFLD by Activating STING–NF-κB Signaling Pathway

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims Sterol regulatory element binding protein cleavage-activating protein (SCAP) is a cholesterol sensor that confers a broad range of functional effects in metabolic diseases.
Xinyu Huang, Yingcheng Yao, Xiaoli S. Hou, Li Wei, Y. Rao, Yu Su, G. Zheng, X. Ruan, Dan-yang Li, Yaxi Chen   +9 more
semanticscholar   +1 more source

Mechanisms of NF-κB p65 and strategies for therapeutic manipulation [PDF]

, 2018
The transcription factor NF-κB is a critical regulator of immune and inflammatory responses. In mammals, the NF-κB/Rel family comprises five members: p50, p52, p65 (Rel-A), c-Rel, and Rel-B proteins, which form homo- or heterodimers and remain as an ...
Giridharan, Sivagami, Srinivasan, Mythily   +1 more
core   +1 more source