Results 31 to 40 of about 456,853 (317)

The NF-κB Signaling Pathway, the Microbiota, and Gastrointestinal Tumorigenesis: Recent Advances

Frontiers in Immunology, 2020
Gastrointestinal (GI) cancers, especially gastric cancer and colorectal cancer (CRC), represent a major global health burden. A large population of microorganisms residing in the GI tract regulate physiological processes, such as the immune response ...
Chao Peng, Yaobin Ouyang, N. Lu, Nianshuang Li   +3 more
semanticscholar   +1 more source

The role of PKM2 nuclear translocation in the constant activation of the NF-κB signaling pathway in cancer-associated fibroblasts

Cell Death and Disease, 2021
Cancer-associated fibroblasts (CAFs) play critical roles in cancer progression by regulating tumor cell proliferation, angiogenesis, and metastasis.
J. Gu, Xuechun Li, Lin Zhao, Ying Yang, Chunling Xue, Yang Gao, Jing Li, Q. Han, Zhao Sun, C. Bai, R. Zhao   +10 more
semanticscholar   +1 more source

CircRNF10-DHX15 interaction suppressed breast cancer progression by antagonizing DHX15-NF-κB p65 positive feedback loop

Cellular & Molecular Biology Letters, 2023
Background Breast cancer (BC) is a common threat to women. The continuous activation of nuclear factor kappa B (NF-κB) signaling pathway contributes to the development of BC.
Wenfang Zheng, Xuehui Wang, Yunhe Yu, Changle Ji, Lin Fang   +4 more
doaj   +1 more source

The anti-malarial artemisinin inhibits pro-inflammatory cytokines via the NF-κB canonical signaling pathway in PMA-induced THP-1 monocytes

International Journal of Molecular Medicine, 2011
Several kinds of sesquiterpene lactones have been proven to inhibit NF-κB and to retard atherosclerosis by reducing lesion size and changing plaque composition. The anti-malarial artemisinin (Art) is a pure sesquiterpene lactone extracted from the Chinese herb Artemisia annua (qinghao, sweet wormwood).
Yue, Wang, Zhouqing, Huang, Liansheng, Wang, Shu, Meng, Yuqi, Fan, Ting, Chen, Jiatian, Cao, Rujia, Jiang, Changqian, Wang   +8 more
openaire   +3 more sources

Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells [PDF]

, 2013
As inhibitor of apoptosis (IAP) proteins can regulate additional signaling pathways beyond apoptosis, we investigated the effect of the second mitochondrial activator of caspases (Smac) mimetic BV6, which antagonizes IAP proteins, on non-apoptotic ...
Eckhardt, Ines, Fulda, Simone, Jennewein, Carla, Rajalingam, Krishnaraj, Tchoghandjian, Aurélie   +4 more
core   +3 more sources

Mesenchymal stem cell-derived exosomes containing miR-145-5p reduce inflammation in spinal cord injury by regulating the TLR4/NF-κB signaling pathway

Cell Cycle, 2021
EXs (Exosomes) secreted by mesenchymal stem cells (MSCs) have the potential to treat spinal cord injury (SCI), this study aimed to further explore the therapeutic effect of EXs on SCI.
Zhensong Jiang, Jianru Zhang
semanticscholar   +1 more source

IRF4b and IRF8 Negatively Regulate RLR-Mediated NF-κB Signaling by Targeting MITA for Degradation in Teleost Fish

Frontiers in Immunology, 2022
Mediator of IRF3 activation (MITA) is a significant signal adaptor in the retinoic acid-inducible gene-I like receptor (RLR) signaling pathway and plays an important role in the innate immune system.
Xiaolong Yan, Xueyan Zhao, Ming Zhou, Yuena Sun, Yuena Sun, Yuena Sun, Tianjun Xu, Tianjun Xu, Tianjun Xu, Tianjun Xu   +9 more
doaj   +1 more source

Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways. [PDF]

, 2012
The NF-κB protein RelB controls dendritic cell (DC) maturation and may be targeted therapeutically to manipulate T cell responses in disease. Here we report that RelB promoted DC activation not as the expected RelB-p52 effector of the noncanonical NF-κB ...
Asagiri, Masataka, Davis-Turak, Jeremy, Fagerlund, Riku, Hoffmann, Alexander, Huang, Jenny Q, Kearns, Jeffrey D, Macal, Monica, Ponomarenko, Julia, Shih, Vincent F-S, Yu, Tony, Zuniga, Elina I   +10 more
core   +2 more sources

Efficacy of herb-partitioned moxibustion at Qihai (CV 6) and bilateral Tianshu (ST 25) on colonic damage and the TLR4/NF-κB signaling pathway in rats with Crohn's disease

Journal of Traditional Chinese Medicine, 2018
To observe the effect of stimulating Qihai (CV 6) and bilateral Tianshu (ST 25) with herb-partitioned moxibustion (HPM) in rats with Crohn's disease (CD), and to investigate the possible anti-inflammatory mechanism of HPM.Forty rats were randomly divided into four groups (n = 10 rats per group): normal control (NC), model control (MC), mesalamine (MES),
Dan, Zhang, Xiaopeng, Ma, Huangan, Wu, Jue, Hong, Cuihong, Zhang, Lingxiang, Wu, Jie, Liu, Yi, Zhu, Ling, Yang, Kai, Wei, Huang, Yan   +10 more
openaire   +2 more sources

METTL3 Promotes Activation and Inflammation of FLSs Through the NF-κB Signaling Pathway in Rheumatoid Arthritis

Frontiers in Medicine, 2021
Rheumatoid arthritis (RA), a common autoimmune disease, is extremely damaging to human health. Fibroblast-like synoviocytes (FLSs) have a vital role in the occurrence and development of RA.
W. Shi, Yan Zheng, Shuai Luo, Xiao-Feng Li, Yilong Zhang, Xiao-ming Meng, Cheng Huang, Jun Li   +7 more
semanticscholar   +1 more source