Results 51 to 60 of about 456,853 (317)

Transcript and protein profiling identifies signaling, growth arrest, apoptosis, and NF-κB survival signatures following GNRH receptor activation [PDF]

, 2013
GNRH significantly inhibits proliferation of a proportion of cancer cell lines by activating GNRH receptor (GNRHR)-G protein signaling. Therefore, manipulation of GNRHR signaling may have an under-utilized role in treating certain breast and ovarian ...
Acharya, Andrew H Sims, ANGELUCCI, Barboule, Beth Harrison, Breitling, Colette Meyer, Dana Faratian, Dangi, EIDNE, Emons, Emons, Emons, Finch, Gentleman, Grundker, Grundker, Grundker, Jianing Bai, Kakar, Kevin Morgan, Kononen, Limonta, Marini, Maudsley, Mebratu, Miller, Moretti, Morgan, Morgan, Morgan, Morwenna Muir, Robert P Millar, Simon P Langdon, Skehan, Straus, Zhu   +36 more
core   +2 more sources

The DNA damage response promotes Polyomavirus JC infection by nucleus to cytoplasm NF-Kappa B activation. [PDF]

, 2017
Background: Infection of glial cells by human neurotropic polyomavirus JC (JCV), the causative agent of the CNS demyelinating disease progressive multifocal leukoencephalopathy (PML), rapidly inflicts damage to cellular DNA.
Bellizzi, Anna, Ibba, Gabriele, Palamara, Anna T., Pietropaolo, Valeria, White, Martyn K., Wollebo, Hassen, Wollebo|   +6 more
core   +1 more source

Modulation of TLR/NF-κB/NLRP Signaling by Bioactive Phytocompounds: A Promising Strategy to Augment Cancer Chemotherapy and Immunotherapy

Frontiers in Oncology, 2022
BackgroundTumors often progress to a more aggressive phenotype to resist drugs. Multiple dysregulated pathways are behind this tumor behavior which is known as cancer chemoresistance. Thus, there is an emerging need to discover pivotal signaling pathways
Sajad Fakhri, Seyed Zachariah Moradi, Seyed Zachariah Moradi, Akram Yarmohammadi, Fatemeh Narimani, Carly E. Wallace, Anupam Bishayee   +6 more
doaj   +1 more source

Model simplification of signal transduction pathway networks via a hybrid inference strategy [PDF]

, 2008
A full-scale mathematical model of cellular networks normally involves a large number of variables and parameters. How to effectively develop manageable and reliable models is crucial for effective computation, analysis and design of such systems.
Asthagiri, Bhalla, Cheong, Conzelmann, Conzelmann, Covert, Dano, Degenring, Fell, Heinrich, Hoffmann, Hoffmann, Ihekwaba, Ingalls, Jia, Kearns, Krishna, Kruger, Lipniacki, Liu, Mauryaa, Nelson, Neves, O'Dea, Werner, Wildermuth, Yue   +26 more
core   +1 more source

Mangiferin Alleviates Mitochondrial ROS in Nucleus Pulposus Cells and Protects against Intervertebral Disc Degeneration via Suppression of NF-κB Signaling Pathway

Oxidative Medicine and Cellular Longevity, 2021
Intervertebral disc degeneration (IVDD), one of the most common clinical diseases worldwide, causes disc herniation and sciatica. Recent studies have identified the involvement of mitochondrial dysfunction, inflammatory responses, and extracellular ...
Haichao Yu, Guowei Hou, Jiankang Cao, Yanyu Yin, Yunpeng Zhao, Lei Cheng   +5 more
semanticscholar   +1 more source

Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer [PDF]

, 2018
The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-kB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological conditions.
Bellavia, Diana, Campese, Antonio Francesco, Felli, MARIA PIA, Ferrandino, Francesca, Grazioli, Paola, Screpanti, Isabella   +5 more
core   +2 more sources

NF-κB signaling pathway in tumor microenvironment

Frontiers in Immunology
The genesis and progression of tumors are multifaceted processes influenced by genetic mutations within the tumor cells and the dynamic interplay with their surrounding milieu, which incessantly impacts the course of cancer.
Yaning Cao, Yanan Yi, Chongxu Han, Bingwei Shi   +3 more
semanticscholar   +1 more source

First Insight into the Modulation of Noncanonical NF-κB Signaling Components by Poxviruses in Established Immune-Derived Cell Lines: An In Vitro Model of Ectromelia Virus Infection

Pathogens, 2020
Dendritic cells (DCs) and macrophages are the first line of antiviral immunity. Viral pathogens exploit these cell populations for their efficient replication and dissemination via the modulation of intracellular signaling pathways.
Justyna Struzik, Lidia Szulc-Dąbrowska, Matylda B. Mielcarska, Magdalena Bossowska-Nowicka, Michał Koper, Małgorzata Gieryńska   +5 more
doaj   +1 more source

Pharmacological strategies in lung cancer-induced cachexia: effects on muscle proteolysis, autophagy, structure, and weakness [PDF]

, 2014
Muscle wasting and cachexia are important systemic manifestations of highly prevalent conditions including cancer. Inflammation, oxidative stress, autophagy, ubiquitin-proteasome system, nuclear factor (NF)-kB, and mitogen activated protein kinases (MAPK)
Bal, Elisa Dora, Barreiro, Eshter, Chacon Cabrera, Alba, Diament, Miriam, Fermoselle, Clara, Mateu Jimenez, Mercè, Sandri, Marco, Urtreger, Alejandro Jorge   +7 more
core   +1 more source

TRIM14 Promotes Noncanonical NF‐κB Activation by Modulating p100/p52 Stability via Selective Autophagy

Advanced Science, 2020
The noncanonical NF‐κB signaling pathway plays a critical role in a variety of biological functions including chronic inflammation and tumorigenesis. Activation of noncanonical NF‐κB signaling largely relies on the abundance as well as the processing of ...
Meixin Chen, Zhiyao Zhao, Qingcai Meng, Puping Liang, Zexiong Su, Yaoxing Wu, Junjiu Huang, Jun Cui   +7 more
doaj   +1 more source