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Targeting the NF-E2-related factor 2 pathway for overcoming leukemia
International Journal of Biological Macromolecules, 2023Leukemia is cancer of the body's blood-forming tissues, including the bone marrow and the lymphatic system. There are many types of leukemia that some of them occur in children and the others are more common in adults. Currently, there are many different chemotherapy agents for leukemia while chemoresistance increases the survival of the leukemic cells.
Mohammad Sadra, Harifi-Mood +5 more
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Clinica Chimica Acta, 2020
Autophagy, an evolutionarily conserved catabolic process, is the most important pathogenic events in the development and progression of liver diseases. Deregulation of Nrf2 is proposed to play a key pathogenic role in hepatocellular carcinoma (HCC). Under certain pathophysiological conditions, such as oxidative stress, impaired autophagy is accompanied
Juan Zhou +10 more
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Autophagy, an evolutionarily conserved catabolic process, is the most important pathogenic events in the development and progression of liver diseases. Deregulation of Nrf2 is proposed to play a key pathogenic role in hepatocellular carcinoma (HCC). Under certain pathophysiological conditions, such as oxidative stress, impaired autophagy is accompanied
Juan Zhou +10 more
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Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) in non-small cell lung cancer
Life Sciences, 2020Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a transcription factor that can regulate downstream target gene expression. Kelch-like ECH-associated protein 1 (Keap1) negatively regulates Nrf2 activation and translocation to target its 26S proteasomal degradation. It has been widely reported that the Keap1/Nrf2 pathway is associated with
Zhi, Zeng +9 more
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Low and High Dose UVB Regulation of Transcription Factor NF-E2-Related Factor 2
Cancer Research, 2006Abstract Transcription factor NF-E2-related factor 2 (Nrf2) regulates antioxidant response element (ARE)–mediated expression and coordinated induction of chemoprotective proteins in response to chemical stress. In this report, we investigated Nrf2 response to low and high dose UVB irradiation.
Sankaranarayanan, Kannan +1 more
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PP019. A new player in preeclampsia: The NF-E2-related factor 2 (NRF2)
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 2013Preeclampsia PE is characterized by diminished antioxidant capacity. These enzymes are mainly regulated via the transcription factor Nrf2.PE is associated with an increase in Nrf2 activity. Nrf2 involves also in the vascular homeostasis during PE. Respective hemodisturbances have been associated with impaired invasion of the extravillous trophoblast ...
Nisreen, Kweider +7 more
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Targeting the NF-E2-Related Factor 2 Pathway: a Novel Strategy for Traumatic Brain Injury
Molecular Neurobiology, 2017As an essential component of cellular defense against a variety of endogenous and exogenous stresses, nuclear factor erythroid 2-related factor 2 (Nrf2) has received increased attention in the past decades. Multiple studies indicate that Nrf2 acts not only as an important protective factor in injury models but also as a downstream target of therapeutic
Li, Zhang, Handong, Wang
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Role of Protein Phosphorylation in the Regulation of NF-E2–Related Factor 2 Activity
2004Publisher Summary The antioxidant response element (ARE) is a cis-acting enhancer that coordinates the induction of a battery of genes in response to oxidative stress and electrophilic compounds. These genes contain the consensus ARE sequence within their promoter region and encode phase II detoxification enzymes or antioxidant proteins.
Philip J, Sherratt +3 more
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Biochemical and Biophysical Research Communications, 2010
Cereblon is a protein encoded by the CRBN gene, which has been associated with human autosomal recessive nonsyndromic mental retardation. However, little is known about the regulation of CRBN expression. Following exposure of mouse neuroblastoma N2A cells to hypoxia/reoxygenation (H/R), mRNA and protein expression of CRBN were increased.
Kyung Jin, Lee +4 more
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Cereblon is a protein encoded by the CRBN gene, which has been associated with human autosomal recessive nonsyndromic mental retardation. However, little is known about the regulation of CRBN expression. Following exposure of mouse neuroblastoma N2A cells to hypoxia/reoxygenation (H/R), mRNA and protein expression of CRBN were increased.
Kyung Jin, Lee +4 more
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The Expression of NF-E2-Related Factor 2 in the Rat Brain After Traumatic Brain Injury
Journal of Trauma: Injury, Infection & Critical Care, 2009Secondary brain damage plays a critical role in the outcome of patients with traumatic brain injury (TBI). The mechanisms underlying secondary brain damage are complex. A target that can interrupt multiple mechanisms underlying secondary brain damage may represent a promising new therapeutic approach for TBI.
Wei, Yan +5 more
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NF-E2-related factor 2 activation in PC12 cells: its protective role in manganese-induced damage
Archives of Toxicology, 2010Manganese neurotoxicity presents with Parkinson-like symptoms that are associated with the generation of reactive oxygen species. Thus, its occurrence and severity can be reduced by cellular antioxidants. The components of the transcription factor NF-E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway are the central regulators of ...
Huangyuan, Li +5 more
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