Results 111 to 120 of about 271,508 (291)

Nanotherapy targeting NF-κB attenuates acute pain after joint injury

Precision Nanomedicine, 2019
Inflammation after joint injury leads to joint responses that result in eventual osteoarthritis development. Blockade of inflammation, by suppressing NF-κB expression, has been shown to reduce joint injury-induced chondrocyte apoptosis and ...
Huimin Yan, Xin Duan, Kelsey H. Collins, Luke E. Springer, Farshid Guilak, Samuel A. Wickline, M. Farooq Rai, Hua Pan, Christine Pham   +8 more
doaj   +1 more source

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

Advanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo, Yalin Wang, Binyu Lu, Yu Zhang, David M. Frazer, Bing Zhou   +5 more
wiley   +1 more source

Computational models of the NF-κB signalling pathway [PDF]

, 2014
In this review article, we discuss the current state of computational modelling of the nuclear factor-kappa B (NF-κB) signalling pathway. NF-κB is a transcription factor, which is ubiquitous within cells and controls a number of immune responses ...
Qwarnstrom, Eva E., Timmis, Jon, Williams, Richard   +2 more
core   +3 more sources

Eggshell membrane hydrolyzates activate NF-κB in vitro: possible implications for in vivo efficacy

Journal of Inflammation Research, 2015
Kevin J Ruff,1 Paul L Durham,2 Austin O’Reilly,2 F Daniel Long1 1ESM Technologies, LLC, Carthage, MO, USA; 2Center for Biomedical and Life Sciences, Missouri State University, Springfield, MO, USA Purpose: Eggshell membrane (ESM) has been shown to
Ruff KJ, Durham PL, O’Reilly A, Long FD   +3 more
doaj  

RPS3‐Enriched Extracellular Vesicles Mediate Liver‐Spinal Cord Inter‐Organ Communication

Advanced Science, EarlyView.
Spinal cord injury activates the liver to send extracellular vesicles loaded with RPS3 protein to the lesion site. These vesicles are taken up by neural stem cells and astrocytes, triggering NF‐κB signaling, impairing the regeneration of neurons and myelin, and promotes harmful inflammation, ultimately hindering recovery.
Peiwen Song, Zuomeng Wu, Yixiang Dong, Yunxiong Fang, Shiyu Bian, Daokuan Wang, Huang Fang, Yunlei Liu, Wang Ying, Jun Qian, Tianyu Han, Cailiang Shen   +11 more
wiley   +1 more source

Androgen receptor targets NFKB and TSPI to suppress prostate tumor growth in vivo [PDF]

, 2007
The androgen role in the maintenance of prostate epithelium is subject to conflicting opinions. While androgen ablation drives the regression of normal and cancerous prostate, testosterone may cause both proliferation and apoptosis. Several investigators
Aurora, Arin, Budunova, Irina, Filleur, Stephanie, Mirochnik, Yelena, Nelius, Thomas, Shroff, E., Veliceasa, Dorina, Volpert, Olga V., Volpert, OV, Northwestern Univ, Feinberg Sch Med, Dept Urol, 303 E Chicago Ave, Chicago, IL 60611 USA, Wang, Zhou, Xiao, Wuhan, Yemelyanov, Alexander   +11 more
core  

Ubiquitin-mediated regulation of RIPK1 kinase activity independent of IKK and MK2 [PDF]

, 2018
Tumor necrosis factor (TNF) can drive inflammation, cell survival, and death. While ubiquitylation-, phosphorylation-, and nuclear factor kappa B (NF-kappa B)-dependent checkpoints suppress the cytotoxic potential of TNF, it remains unclear whether ...
Annibaldi, Alessandro, Bertin, John, Bianchi, Katiuscia, Choi, Sze Men, Elliott, Paul R, John, Sidonie Wicky, Komander, David, Liccardi, Gianmaria, Meier, Pascal, Ruan, Jianbin, Silke, John, Swatek, Kirby N, Van Coillie, Samya, Vanden Berghe, Tom, Vandenabeele, Peter, Wu, Hao   +15 more
core   +2 more sources

MR‐DELTAnet: A Longitudinal MRI‐Transformer Model Predicting Pathological Complete Response and Revealing Immune Microenvironment via scRNA‐seq in Locally Advanced Rectal Cancer

Advanced Science, EarlyView.
The MR‐DELTAnet model utilizes longitudinal MRI to predict treatment response after neoadjuvant chemoradiotherapy in locally rectal cancer patients, accurately identifying patients likely to achieve pathological complete response for personalized management.
Wuteng Cao, Huaxian Chen, Jiao Li, Yihui Zheng, Liqing Xie, Guozhong Xiao, Zeyan Wang, Fen Yuan, Junhong Chen, Chongbao Sun, Jing Dai, Jinping Zeng, Xinhua Wang, Lei Wu, Hongcheng Lin   +14 more
wiley   +1 more source

TNF-induced activation of NF-kappa B.

Immunobiology, 1996
Tumor Necrosis Factor (TNF) is one of the most potent physiological inducers of the nuclear transcription factor NF-kappa B. In light of the pivotal role of NF-kappa B in the development of immune responses and activation of HIV replication, the identification of TNF signal transduction pathways involved in NF-kappa B activation is of particular ...
S, Schütze, K, Wiegmann, T, Machleidt, M, Krönke   +3 more
openaire   +2 more sources

Vaccinia virus protein B14, an inhibitor of NF-κB activation, and its counterpart in MVA

, 2010
Vaccinia virus (VACV) encodes multiple proteins which modulate NF-[kappa]B activation to evade the host immune response. One example is B14, a virulence factor that reduces NF-[kappa]B activation via interaction with IKK [Beta].
McCoy, Laura Ellen, McCoy, Laura Ellen
core   +1 more source