Results 1 to 10 of about 108,193 (313)

Research of neuroprotective properties of TrkA-receptor agonist GK-2 on model of oxidative stress in human vascular endothelial cells (HUVEC)

Фармакокинетика и Фармакодинамика, 2019
Oxidative stress resulted to decrease in cells viability compared to the control (78 ± 5 % and 100 ± 6 %, respectively, р < 0,05). GK-2 and NGF prevented H2O2-induced HUVEC cells damages (95 ± 3 % for HA-2 and 97 ± 4 % for NGF vs.
T. A. Antipova, S. V. Nikolaev, S. A. Kryzhanovsky, E. S. Pekeldina   +3 more
doaj   +1 more source

Changes of Nerve Growth Factor Synthesis in Nonneuronal Cells in Response to Sciatic Nerve Transection [PDF]

, 1987
The intact sciatic nerve contains levels of nerve growth factor (NGF) that are comparable to those of densely innervated peripheral target tissues of NGF-responsive (sympathetic and sensory) neurons.
Bandtlow, Christine, Heumann, Rolf, Korsching, Sigrun, Thoenen, Hans   +3 more
core  

Correlations within the Non-Equilibrium Green's Function Method

, 2017
Non-equilibrium Green's Function (NGF) method is a powerful tool for studying the evolution of quantum many-body systems. Different types of correlations can be systematically incorporated within the formalism.
Danielewicz, P., Mahzoon, M. H., Rios, A.   +2 more
core   +1 more source

Involvement of ras p2I in Neurotrophin-induced Response of Sensory, but Not Sympathetic Neurons [PDF]

, 1993
Little is known about the signal transduction mechanisms involved in the response to neurotrophins and other neurotrophic factors in neurons, beyond the activation of the tyrosine kinase activity of the neurotrophin receptors belonging to the trk family.
Barde, Y. A., Borasio, Gian Domenico, Heumann, R., Markus, A., Wittinghofer, A.   +4 more
core   +3 more sources

Characterisation of ERK distribution and activity in rat pheochromocytoma cells : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Molecular Biology at Massey University [PDF]

, 1998
Nerve growth factor (NGF) binds to the NGF receptor, TrkA, at the tips of nerve cell axons, sending a signal that prevents programmed cell death and causes survival, growth, and differentiation of the nerve cell.
MacCormick, Matthew Edgar
core  

Trim17, novel E3 ubiquitin-ligase, initiates neuronal apoptosis [PDF]

, 2010
Accumulating data indicate that the ubiquitin-proteasome system controls apoptosis by regulating the level and the function of key regulatory proteins. In this study, we identified Trim17, a member of the TRIM/RBCC protein family, as one of the critical ...
A Bobba, A Brunet, A Lipkin, A Reymond, AP Aalto, B Pettmann, CM Knudson, CM Pickart, DA Cross, DA Cross, DA Linseman, DP Martin, E Towers, F Jaudon, G Lutfalla, G Meroni, GV Putcha, I Lassot, I Robbins, J Gilley, J Ham, J Ham, J Whitfield, J Yuan, JX Comella, KA Wood, L Swainson, L Vanhille, M Broemer, M Kristiansen, M M Magiera, M Sardiello, MH Glickman, N Canu, R Bhat, R Rahmeh, R Sadoul, RJ Youle, S Desagher, S Desagher, S Mora, S Ogawa, SJ Riedl, SJ Thompson, SR D'Mello, SR Datta, T Urano, TM Miller, TM Miller, V Arce, V Hongisto, Y Du, Z Xia   +52 more
core   +3 more sources

Ca2+ transients are not required as signals for long-term neurite outgrowth from cultured sympathetic neurons [PDF]

, 1990
A method for clamping cytosolic free Ca2+ ([Ca2+]i) in cultures of rat sympathetic neurons at or below resting levels for several days was devised to determine whether Ca2+ signals are required for neurite outgrowth from neurons that depend on Nerve ...
Murrell, R D, Suidan, H S, Tolkovsky, A M, Walker, A E   +3 more
core   +2 more sources

Phase I trial of recombinant human nerve growth factor for neurotrophic keratitis [PDF]

, 2018
Neurotrophic keratitis/keratopathy (NK), a rare degenerative corneal disease, lacks effective pharmacologic therapies.1 Because NK pathology involves trigeminal nerve damage and loss of corneal innervation, nerve growth factor (NGF) is surmised to ...
Alio, Jorge, Allegretti, Marcello, Aragona, Pasquale, Benitez del Castillo, José, Bonini, Stefano, Bonini, Stefano, Bouheraoua, Nacim, Carley, Fiona, Chao, Wendy, Creuzot-Garcher, Catherine, Cursiefen, Claus, Dart, John, De La Paz, Maria, Etxebarria, Jaime, Figueiredo, Francisco, Filatori, Isabella, Fogagnolo, Paolo, Gabison, Eric, Geerling, Gerd, Hossain, Parwez, Kanna, Ramaesh, Koppen, Carina, Kruse, Friedrich, Lambiase, Alessandro, Lambiase, Alessandro, Leonardi, Andrea, Lorenz, Katrin, Malecaze, François, Mantelli, Flavio, Mastropasqua, Leonardo, Mencucci, Rita, Merayo-Lloves, Jesús, Messmer, Elisabeth, Montero, Jesus, Murta, Joaquim Neto, Nemeth, Janos, Rama, Paolo, Rama, Paolo, Rauz, Saaeha, Reinhard, Thomas, Robert, Pierre-Yves, Rolando, Maurizio, Sainz de la Maza, Maite, Szaflik, Jacek P., Torrao, Luis, Wylegala, Edward   +45 more
core   +1 more source

Effects of Crocin on Brain Neurotrophins, Cognition, Balance and Pain in Toxic-Induced Demyelination Model

Acta Neurologica Taiwanica
Objective: The purpose of this study was to investigate the effects of Crocin on brain neuroterophins, cognition, sensory and motor dysfunction and compare to fingolimod effects in toxic-induced demyelination with Ethidium Bromide (EB) in female Wistar ...
Rouholah Fatemi, Hadi Fathi Moghaddam, Yaghoub Farbod, Roya Bigtashkhani   +3 more
doaj   +1 more source

IMMUNOHISTOCHEMICAL EXPRESSION OF NGF/TrkA AND BDNF/TrkB IN TUMOR PARIENCHYMA AND PERIPROSTATIC ADIPOSE TISSUE, DEPENDING ON THE PATHOANATOMIC STAGE OF PROSTATE CANCER [PDF]

Journal of IMAB
Introduction: For more than 30 years, the idea of inhibiting growth factors has taken over the minds of different generations of scientists since the progression of the neoplastic process is determined by uncontrolled proliferation differentiation and ...
Nikolay Evtimov
doaj   +1 more source