Results 11 to 20 of about 99,548 (294)

A novel anti-NGF PEGylated Fab’ provides analgesia with lower risk of adverse effects

mAbs, 2023
Nerve growth factor (NGF) has emerged as a key driver of pain perception in several chronic pain conditions, including osteoarthritis (OA), and plays an important role in the generation and survival of neurons.
Yukari Koya, Hirotsugu Tanaka, Eiji Yoshimi, Nobuaki Takeshita, Shuji Morita, Hiroki Morio, Kanako Mori, Hiroshi Fushiki, Masazumi Kamohara   +8 more
doaj   +1 more source

Cdk5 activation promotes Cos-7 cells transition towards neuronal-like cells

Translational Neuroscience, 2023
Cyclin-dependent kinase 5 (Cdk5) activity is specifically active in neurogenesis, and Cdk5 and neocortical neurons migration related biomarker are expressed in Cos-7 cells.
Bao Li, Lan Xiao-Mei, Zhang Guo-Qing, Bao Xi, Li Bo, Ma Dan-Na, Luo Hong-Yan, Cao Shi-Lu, Liu Shun-Yao, Jing E, Zhang Jian-Zhong, Zheng Ya-Li   +11 more
doaj   +1 more source

The strategic uses of collagen in adherent cell cultures

Cell Biology International, Volume 47, Issue 2, Page 367-373, February 2023., 2023
Abstract The culture of adherent mammalian cells involves adhesion to the tissue culture vessel. This requires attachment factors from serum and/or a suitable substrate on the vessel surface. Some cells require collagen or other substrates to promote neurite outgrowth, differentiation or growth.
PinFen Chua, William K. Lim
wiley   +1 more source

One at a time, live tracking of NGF axonal transport using quantum dots [PDF]

, 2007
Retrograde axonal transport of nerve growth factor (NGF) signals is critical for the survival, differentiation, and maintenance of peripheral sympathetic and sensory neurons and basal forebrain cholinergic neurons.
A. Ramirez, B. Cui, Beattie, Bhattacharyya, Bomont, Bonneau, Bronfman, C. Wu, Campenot, Chan, Claude, Delcroix, E. L. Bearer, Fu, Giepmans, Ginty, Grimes, Hohng, Howe, Korsching, Kuruvilla, L. Chen, Lidke, Miller, Mobley, Pinaud, Reynolds, Reynolds, Rosenberg, S. Chu, Salehi, Sofroniew, Tani, Taylor, Ure, Valdez, von Bartheld, Vu, W. C. Mobley, W.-P. Li, Watson, Weible, Wu, Ye, Zhuang, Zweifel   +45 more
core   +2 more sources

A method to investigate muscle target‐specific transcriptional signatures of single motor neurons

Developmental Dynamics, Volume 252, Issue 1, Page 208-219, January 2023., 2023
Abstract Background Motor neurons in the vertebrate spinal cord have long served as a paradigm to study the transcriptional logic of cell type specification and differentiation. At limb levels, pool‐specific transcriptional signatures first restrict innervation to only one particular muscle in the periphery, and get refined, once muscle connection has ...
Bianka Berki, Fabio Sacher, Antoine Fages, Patrick Tschopp, Maëva Luxey   +4 more
wiley   +1 more source

Wiring the senses: Factors that regulate peripheral axon pathfinding in sensory systems

Developmental Dynamics, Volume 252, Issue 1, Page 81-103, January 2023., 2023
Abstract Sensory neurons of the head are the ones that transmit the information about the external world to our brain for its processing. Axons from cranial sensory neurons sense different chemoattractant and chemorepulsive molecules during the journey and in the target tissue to establish the precise innervation with brain neurons and/or receptor ...
Gemma Nomdedeu‐Sancho, Berta Alsina
wiley   +1 more source

Interplay between hysteresis and nonlocality during onset and arrest of flow in granular materials [PDF]

Soft Matter 17, 7359-7375 (2021), 2021
The jamming transition in granular materials is well-known for exhibiting hysteresis, wherein the level of shear stress required to trigger flow is larger than that below which flow stops. Although such behavior is typically modeled as a simple non-monotonic flow rule, the rheology of granular materials is also nonlocal due to cooperativity at the ...
arxiv   +1 more source

Influence of the complex drug Cocarnit on the sciatic nerve in the development of diabetic polyneuropathy in rats

Current Issues in Pharmacy and Medical Sciences, 2020
Ulcers and slow wound healing are common in diabetic polyneuropathy (DP), as well as shooting or burning pain, sensitivity to touch or lack of sensitivity, low oxygenation of nerve tissue, conductivity disorders and various vascular disorders.
Nikitina Nataliia, Berehoviy Serhii, Stepanova Ludmila, Savchuk Olexiy, Kuryk Olena, Ostapchenko Ludmila, Beregova Tetyana   +6 more
doaj   +1 more source

Protective effects of Derinat, a nucleotide-based drug, on experimental traumatic brain injury, and its cellular mechanisms

Медицинская иммунология, 2021
Traumatic brain injury is the most common cause of death and disability in young people including sport athletes and soldiers, people under 45 years of age in the industrialized countries, representing a growing health problem in developing countries, as
E. A. Korneva, E. V. Dmitrienko, S. Miyamura, M. Noda, N. Akimoto   +4 more
doaj   +1 more source

The Transcriptional Corepressor NAB2 Inhibits NGF-induced Differentiation of PC12 Cells [PDF]

, 1998
The PC12 pheochromocytoma cell line responds to NGF by undergoing growth arrest and proceeding to differentiate toward a neuronal phenotype. Among the early genetic events triggered by NGF in PC12 cells are the rapid activation of the zinc finger ...
Davidson, Norman, Ehrengruber, Markus U., Milbrandt, Jeffrey, Qu, Zhican, Svaren, John, Wolfraim, Lawrence A.   +5 more
core   +2 more sources