Results 21 to 30 of about 99,548 (294)

Pathogenetic role of the pain threshold Hypothetical therapeutic perspectives based on the use of drugs to elevate it

open access: yesPathos, 2023
The pain threshold determines the extent of pain perception, and in some cases, its manifestation. Therefore, it is important in certain situations to increase the pain threshold. Measuring the pain threshold is challenging due to its approximate nature.
Guido Orlandini
doaj  

Effect of GK-1 NGF Loop 4 Dipeptide Mimetic on tumor growth and metastasis of Lewis lung carcinoma in experiment on male C57BL/6 mice

open access: yesФармакокинетика и Фармакодинамика, 2023
Article describes results of study of antitumor and antimetastatic action of dipeptide mimetic of the nerve growth factor amide N-monosuccinyl-L-glutamyl-L-lysine (compound GK-1) in comparison with gemcitabine. Two injections of gemcitabine in total dose
L. P. Kovalenko   +3 more
doaj   +1 more source

Phase I trial of recombinant human nerve growth factor for neurotrophic keratitis [PDF]

open access: yes, 2018
Neurotrophic keratitis/keratopathy (NK), a rare degenerative corneal disease, lacks effective pharmacologic therapies.1 Because NK pathology involves trigeminal nerve damage and loss of corneal innervation, nerve growth factor (NGF) is surmised to ...
Alio, Jorge   +45 more
core   +1 more source

Network geometry with flavor: from complexity to quantum geometry [PDF]

open access: yesPhys. Rev. E 93, 032315 (2016), 2015
Here we introduce the Network Geometry with Flavor $s=-1,0,1$ (NGF) describing simplicial complexes defined in arbitrary dimension $d$ and evolving by a non-equilibrium dynamics. The NGF can generate discrete geometries of different nature, ranging from chains and higher dimensional manifolds to scale-free networks with small-world properties, scale ...
arxiv   +1 more source

Increased expression and activity of p75NTR are crucial events in azacitidine-induced cell death in prostate cancer [PDF]

open access: yes, 2016
The high affinity nerve growth factor (NGF) NGF receptor, p75NTR, is a member of the tumor necrosis factor (TNF) receptor superfamily that shares a conserved intracellular death domain capable of inducing apoptosis and suppressing growth in prostate ...
Biordi, Leda   +9 more
core   +2 more sources

Experimental muscle hyperalgesia modulates sensorimotor cortical excitability, which is partially altered by unaccustomed exercise [PDF]

open access: yes, 2018
Impaired corticomotor function is reported in patients with lateral epicondylalgia, but the causal link to pain or musculotendinous overloading is unclear.
De Martino, Enrico   +4 more
core   +3 more sources

NGF-response of EGF-dependent progenitor cells obtained from human sympathetic ganglia [PDF]

open access: yes, 1994
SIGNALLING molecules are thought to play a significant role in determining the fate of neural crest progenitor cells. The human sympathetic chain was identified at 6.5, 7.5, 8.2, 10.2 and 11.4 postconception (PC) weeks demonstrating low affinity nerve ...
Ampietro, A.   +6 more
core   +1 more source

Proliferating cell nuclear antigen (PCNA) allows the automatic identification of follicles in microscopic images of human ovarian tissue [PDF]

open access: yesPathology and Laboratory Medicine International 2010:2; 99-105, 2010
Human ovarian reserve is defined by the population of nongrowing follicles (NGFs) in the ovary. Direct estimation of ovarian reserve involves the identification of NGFs in prepared ovarian tissue. Previous studies involving human tissue have used hematoxylin and eosin (HE) stain, with NGF populations estimated by human examination either of tissue ...
arxiv   +1 more source

Three-dimensional granular flow continuum modeling via material point method with hyperelastic nonlocal granular fluidity [PDF]

open access: yes, 2021
The accurate and efficient modeling of granular flows and their interactions with external bodies is an open research problem. Continuum methods can be used to capture complexities neglected by terramechanics models without the computational expense of discrete element methods.
arxiv   +1 more source

Network meta‐analysis of randomized trials in multiple myeloma: Efficacy and safety in frontline therapy for patients not eligible for transplant

open access: yesHematological Oncology, Volume 40, Issue 5, Page 987-998, December 2022., 2022
Abstract The treatment scenario for newly‐diagnosed transplant‐ineligible multiple myeloma patients (NEMM) is quickly evolving. Currently, combinations of proteasome inhibitors and/or immunomodulatory drugs +/− the monoclonal antibody Daratumumab are used for first‐line treatment, even if head‐to‐head comparisons are lacking.
Cirino Botta   +17 more
wiley   +1 more source

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