The pain threshold determines the extent of pain perception, and in some cases, its manifestation. Therefore, it is important in certain situations to increase the pain threshold. Measuring the pain threshold is challenging due to its approximate nature.
Guido Orlandini
doaj
Article describes results of study of antitumor and antimetastatic action of dipeptide mimetic of the nerve growth factor amide N-monosuccinyl-L-glutamyl-L-lysine (compound GK-1) in comparison with gemcitabine. Two injections of gemcitabine in total dose
L. P. Kovalenko+3 more
doaj +1 more source
Phase I trial of recombinant human nerve growth factor for neurotrophic keratitis [PDF]
Neurotrophic keratitis/keratopathy (NK), a rare degenerative corneal disease, lacks effective pharmacologic therapies.1 Because NK pathology involves trigeminal nerve damage and loss of corneal innervation, nerve growth factor (NGF) is surmised to ...
Alio, Jorge+45 more
core +1 more source
Network geometry with flavor: from complexity to quantum geometry [PDF]
Here we introduce the Network Geometry with Flavor $s=-1,0,1$ (NGF) describing simplicial complexes defined in arbitrary dimension $d$ and evolving by a non-equilibrium dynamics. The NGF can generate discrete geometries of different nature, ranging from chains and higher dimensional manifolds to scale-free networks with small-world properties, scale ...
arxiv +1 more source
Increased expression and activity of p75NTR are crucial events in azacitidine-induced cell death in prostate cancer [PDF]
The high affinity nerve growth factor (NGF) NGF receptor, p75NTR, is a member of the tumor necrosis factor (TNF) receptor superfamily that shares a conserved intracellular death domain capable of inducing apoptosis and suppressing growth in prostate ...
Biordi, Leda+9 more
core +2 more sources
Experimental muscle hyperalgesia modulates sensorimotor cortical excitability, which is partially altered by unaccustomed exercise [PDF]
Impaired corticomotor function is reported in patients with lateral epicondylalgia, but the causal link to pain or musculotendinous overloading is unclear.
De Martino, Enrico+4 more
core +3 more sources
NGF-response of EGF-dependent progenitor cells obtained from human sympathetic ganglia [PDF]
SIGNALLING molecules are thought to play a significant role in determining the fate of neural crest progenitor cells. The human sympathetic chain was identified at 6.5, 7.5, 8.2, 10.2 and 11.4 postconception (PC) weeks demonstrating low affinity nerve ...
Ampietro, A.+6 more
core +1 more source
Proliferating cell nuclear antigen (PCNA) allows the automatic identification of follicles in microscopic images of human ovarian tissue [PDF]
Human ovarian reserve is defined by the population of nongrowing follicles (NGFs) in the ovary. Direct estimation of ovarian reserve involves the identification of NGFs in prepared ovarian tissue. Previous studies involving human tissue have used hematoxylin and eosin (HE) stain, with NGF populations estimated by human examination either of tissue ...
arxiv +1 more source
Three-dimensional granular flow continuum modeling via material point method with hyperelastic nonlocal granular fluidity [PDF]
The accurate and efficient modeling of granular flows and their interactions with external bodies is an open research problem. Continuum methods can be used to capture complexities neglected by terramechanics models without the computational expense of discrete element methods.
arxiv +1 more source
Abstract The treatment scenario for newly‐diagnosed transplant‐ineligible multiple myeloma patients (NEMM) is quickly evolving. Currently, combinations of proteasome inhibitors and/or immunomodulatory drugs +/− the monoclonal antibody Daratumumab are used for first‐line treatment, even if head‐to‐head comparisons are lacking.
Cirino Botta+17 more
wiley +1 more source