Results 81 to 90 of about 108,193 (313)

Advancing the Tendinopathy Triad: Comment on “Tendinopathy: The Interplay Between Mechanical Stress, Inflammation, and Vascularity”

Advanced Science, EarlyView.
Abstract Building upon the integrative framework of tendinopathy proposed by Gehwolf et al.—which elegantly connects mechanical stress, inflammation, and vascularity—this commentary extends the discussion by introducing novel mechanistic insights and future research directions that move beyond the established triad. A paradigm shift is proposed ...
DuJiang Yang, Jiexiang Yang, Shuang Wang, GuoYou Wang   +3 more
wiley   +1 more source

Up-regulation of nerve growth factor in cholestatic livers and its hepatoprotective role against oxidative stress.

PLoS ONE, 2014
The role of nerve growth factor (NGF) in liver injury induced by bile duct ligation (BDL) remains elusive. This study aimed to investigate the relationship between inflammation and hepatic NGF expression, to explore the possible upstream molecules up ...
Ming-Shian Tsai, Yu-Chun Lin, Cheuk-Kwan Sun, Shih-Che Huang, Po-Huang Lee, Ying-Hsien Kao   +5 more
doaj   +1 more source

Future directions for the management of pain in osteoarthritis. [PDF]

, 2014
Osteoarthritis (OA) is the predominant form of arthritis worldwide, resulting in a high degree of functional impairment and reduced quality of life owing to chronic pain. To date, there are no treatments that are known to modify disease progression of OA
Aigner T, Anasuya Kuttapitiya, Balanescu AR, Bannuru RR, Chou R, da Costa BR, Danielsson L, Fanelli A, Fransen M, Haviv B, Huskisson EC, Lim YZ, Mankin HJ, McAlindon TE, Merlotti D, Nguyen US, Nidhi Sofat, Pelletier JP, Sagar DR, Sellers RS, Sofat N, Tannenbaum H, Wajed J, Wakitani S   +23 more
core   +1 more source

Schwann Cell Synthesized Cholesterol Orchestrates Peripheral Nerve Regeneration via Structural and IGF1‐Dependent Signaling Mechanisms

Advanced Science, EarlyView.
This study reveals that Schwann cell FDFT1‐mediated cholesterol synthesis is essential for peripheral nerve regeneration via dual roles: as a structural component for myelin and as a metabolic signal that upregulates IGF1. IGF1 promotes axonal growth through paracrine action and enhances Schwann cell differentiation/ myelination via an intrinsic IGF1R ...
Shuyi Xu, Ye He, Ying Zou, Mengyao Zhao, Jiaqi Zhang, Yizhou Xu, Jiale Cai, Xiongbo Luo, Xinrui Ma, Saini Wu, Yuling Huang, Xianghai Wang, Jiasong Guo   +12 more
wiley   +1 more source

Pulsed Electromagnetic Fields: A Novel Attractive Therapeutic Opportunity for Neuroprotection After Acute Cerebral Ischemia

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Acute cerebral ischemia is characterized by several pathological processes evolving during time, which contribute to the final tissue damage. Secondary processes, such as prolonged inflammatory response, impaired mitochondrial function and oxidative stress, are responsible for the progression of brain injury to the peri‐infarct area,
Fioravante Capone, Simona Salati, Fabrizio Vincenzi, Micaela Liberti, Giorgio Aicardi, Francesca Apollonio, Katia Varani, Ruggero Cadossi, Vincenzo Di Lazzaro   +8 more
wiley   +1 more source

Ulinastatin Promotes Regeneration of Peripheral Nerves After Sciatic Nerve Injury by Targeting let-7 microRNAs and Enhancing NGF Expression

Drug Design, Development and Therapy, 2020
Jincheng Zhang, Yingqi Zhang, Lei Chen, Zhitao Rao, Yeqing Sun Department of Orthopedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, People’s Republic of ChinaCorrespondence: Yeqing SunDepartment of Orthopedics Tongji ...
Zhang J, Zhang Y, Chen L, Rao Z, Sun Y
doaj  

Pro‐Inflammatory c‐Met+ CD4 T Cells in Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Hepatocyte growth factor (HGF) binds exclusively the c‐Met surface receptor, and the HGF/c‐Met axis regulates T cell function in autoimmune diseases. We analyzed c‐Met expression on human CD4 T cells in the blood and cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS) versus non‐inflammatory neurological disease (NIND), to ...
Gautier Breville, Mahdia Benkhoucha, Ayman Rezk, Ngoc Lan Tran, Isis Senoner, Amit Bar‐Or, Patrice H. Lalive   +6 more
wiley   +1 more source

Small Interfering RNA Targeting Nerve Growth Factor Alleviates Allergic Airway Hyperresponsiveness

Molecular Therapy: Nucleic Acids, 2014
Airway hyperresponsiveness is the hallmark of allergic asthma and caused by multiple factors. Nerve growth factor (NGF), a neurotrophin, is originally known for regulation of neural circuit development and function.
Yi-Lien Chen, Hsin-Ying Huang, Chen-Chen Lee, Bor-Luen Chiang   +3 more
doaj   +1 more source

Cellular Localization of NGF and NGF Receptors in Aged Human Thymus

Folia Biologica, 2003
Recent evidence indicates that some thymic cells of developing and adult laboratory animals express the neurotrophin NGF and its low-affinity p75NTR and high-affinity TrkA receptor. Less is known as to whether the thymus of adult and aged humans express these markers. We hypothesize that the presence and distribution of immunopositive cells for NGF and
Marinova T, Velikova K, Philipov S, Stankulov I, Chaldakov G, Aloe L   +5 more
openaire   +4 more sources

Bioprinted Excitable Tissues with Multistimulation Systems for Promoting Function and Maturation

Advanced NanoBiomed Research, EarlyView.
This review provides an overview of stimulation strategies used to enhance the functional maturation of bioprinted excitable tissues. It addresses key limitations in physiological performance of bioprinted excitable tissues, outlines major stimulation modalities—including electrical, mechanical, optical, magnetic, ultrasound, and hybrid—and examines ...
Uijung Yong, Jinseon Park, Jinah Jang
wiley   +1 more source