Results 61 to 70 of about 91,799 (300)

Niacin inhibits surface expression of ATP synthase β chain in HepG2 cells: implications for raising HDL

Journal of Lipid Research, 2008
Niacin is an effective agent for raising HDL, but its cellular target sites are largely unknown. We examined effects of niacin on the surface expression of ATP synthase β chain, a newly described HDL/apolipoprotein A-I (apoA-I) receptor for HDL ...
Lin-Hua Zhang, Vaijinath S. Kamanna, Michael C. Zhang, Moti L. Kashyap   +3 more
doaj   +1 more source

Prolonged niacin treatment leads to increased adipose tissue PUFA synthesis and anti-inflammatory lipid and oxylipin plasma profile[S]

Journal of Lipid Research, 2014
Prolonged niacin treatment elicits beneficial effects on the plasma lipid and lipoprotein profile that is associated with a protective CVD risk profile.
Mattijs M. Heemskerk, Harish K. Dharuri, Sjoerd A.A. van den Berg, Hulda S. Jónasdóttir, Dick-Paul Kloos, Martin Giera, Ko Willems van Dijk, Vanessa van Harmelen   +7 more
doaj   +1 more source

Scientific Opinion on Dietary Reference Values for niacin [PDF]

EFSA Journal, 2014
Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for niacin. Niacin is a generic term for nicotinic acid and nicotinamide. Niacin can be synthesised in
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)
doaj   +1 more source

Effect of Niacin on Inflammation and Angiogenesis in a Murine Model of Ulcerative Colitis

Scientific Reports, 2017
Butyrate and niacin are produced by gut microbiota, however butyrate has received most attention for its effects on colonic health. The present study aimed at exploring the effect of niacin on experimental colitis as well as throwing some light on the ...
Hesham Aly Salem, Walaa Wadie
doaj   +1 more source

The I148M PNPLA3 variant mitigates niacin beneficial effects: How the genetic screening in non-alcoholic fatty liver disease patients gains value

Frontiers in Nutrition, 2023
BackgroundThe PNPLA3 p.I148M impact on fat accumulation can be modulated by nutrients. Niacin (Vitamin B3) reduced triglycerides synthesis in in vitro and in vivo NAFLD models.ObjectivesIn this study, we aimed to investigate the niacin-I148M polymorphism
Erika Paolini, Erika Paolini, Miriam Longo, Miriam Longo, Marica Meroni, Giada Tria, Annalisa Cespiati, Annalisa Cespiati, Rosa Lombardi, Rosa Lombardi, Sara Badiali, Marco Maggioni, Anna Ludovica Fracanzani, Anna Ludovica Fracanzani, Paola Dongiovanni   +14 more
doaj   +1 more source

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source

Roles of reconstituted high-density lipoprotein nanoparticles in cardiovascular disease: A new paradigm for drug discovery [PDF]

, 2020
Epidemiological results revealed that there is an inverse correlation between high-density lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease (ASCVD).
Huang, Hui, Huang, Jiansheng, Huang, Li-Hao, Wang, Dongdong   +3 more
core   +2 more sources

Traceless Regulation of Genetic Circuitry

Advanced Science, EarlyView.
Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley   +1 more source

Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice

Annals of Neurology, EarlyView.
A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi, John Williamson, Huayu Sun, Suchitra Joshi, Rachel Jane Spera, Savaira Zaib, Supriya Sharma, Chengsan Sun, Andrey Brodovskiy, Ifrah Zawar, Jaideep Kapur   +10 more
wiley   +1 more source

Association between dietary intake of niacin and stroke in the US residents: evidence from national health and nutrition examination survey (NHANES) 1999–2018

Frontiers in Nutrition
ObjectiveThis study aims to explore the association between niacin intake and stroke within a diverse, multi-ethnic population.MethodsA stringent set of inclusion and exclusion criteria led to the enrollment of 39,721 participants from the National ...
Jie-Yu Qiu, Wen-Hui Zhang, Xiao-Ming Zhu, Li-Da Wu, Ji-Hua Huang, Jie Zhang   +5 more
doaj   +1 more source