Expression analysis elucidates the roles of Nicastrin, Notch4, and Hes1 in prognosis and endocrine-therapy resistance in ER-positive breast cancer patients [PDF]
Research in Pharmaceutical Sciences, 2023 Background and purpose: Although some proposed mechanisms responsible for tamoxifen resistance have already been present, further study is needed to determine the mechanisms underlying tamoxifen resistance more clearly.
Arad Boustan +5 more
doaj +3 more sources
Expression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer’s, and liver cancer [PDF]
European Journal of Medical ResearchBackground Nicastrin, a subunit of the γ-secretase complex, is encoded by the NCSTN gene and regulates notch signaling, it is involved in the pathogenesis of hidradenitis suppurativa (HS), Alzheimer disease (AD), and liver cancer.
Lu Yan +11 more
doaj +4 more sources
Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase complex, as independent molecular domains [PDF]
Molecular Brain, 2021 Alterations in the canonical processing of Amyloid Precursor Protein generate proteoforms that contribute to the onset of Alzheimer’s Disease. Modified composition of γ-secretase or mutations in its subunits has been directly linked to altered generation
Shekhar Kedia +5 more
doaj +2 more sources
Validation of a commercial antibody to detect endogenous human nicastrin by immunoblot [version 2; peer review: 2 approved, 1 approved with reservations] [PDF]
F1000Research, 2020 Nicastrin (NCSTN) is a transmembrane glycoprotein that is part of the gamma-secretase complex. Gamma-secretase is a protease complex that cleaves type-I single-pass transmembrane proteins.
Rosana A. Mesa, Elisha D.O. Roberson
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MicroRNAs targeting Nicastrin regulate Aβ production and are affected by target site polymorphisms [PDF]
Frontiers in Molecular Neuroscience, 2014 Despite the growing number of genome-wide association studies, the involvement of polymorphisms in microRNA target sites (polymiRTS) in Alzheimer’s disease (AD) remains poorly investigated.
Charlotte eDelay +10 more
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Neurobiology of Disease, 2007 Nicastrin is an integral member of PS-complexes that perform γ-secretase cleavage of numerous type I membrane proteins including amyloid precursor protein that underlies Alzheimer's disease; thus, diminishing γ-secretase activity by reducing levels of ...
Sonya Brijbassi +5 more
doaj +2 more sources
Antibody Responses and the Vaccine Efficacy of Recombinant Glycosyltransferase and Nicastrin Against Schistosoma japonicum [PDF]
PathogensSchistosomiasis is a neglected tropical disease and the second most common parasitic disease after malaria. While praziquantel remains the primary treatment, concerns about drug resistance highlight the urgent need for new drugs and effective vaccines to
Bowen Dong +6 more
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Effect of nicastrin on hepatocellular carcinoma proliferation and apoptosis through PI3K/AKT signalling pathway modulation [PDF]
Cancer Cell International, 2020 Background Increasing evidence has proven that the γ-secretase complex plays significant roles in the carcinogenesis of malignancies. However, the independent effect of nicastrin (NCSTN), the largest constituent of the γ-secretase complex, on the ...
Xicheng Wang +6 more
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PLoS ONE, 2011 Nicastrin is an obligatory component of the γ-secretase; the enzyme complex that leads to the production of Aβ fragments critically central to the pathogenesis of Alzheimer's disease (AD).
Michelle K Lupton +16 more
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Mannose Promotes β‐Amyloid Pathology by Regulating BACE1 Glycosylation in Alzheimer's Disease [PDF]
Advanced ScienceHyperglycemia accelerates Alzheimer's disease (AD) progression, yet the role of monosaccharides remains unclear. Here, it is demonstrated that mannose, a hexose, closely correlates with the pathological characteristics of AD, as confirmed by measuring ...
Chensi Liang +9 more
doaj +2 more sources