Results 31 to 40 of about 3,289 (188)
Microorganisms, 2021 Nicastrin (NICT) is a transmembrane protein physically associated with the polytypical aspartyl protease presenilin that plays a vital role in the correct localization and stabilization of presenilin to the membrane-bound γ-secretase complex.
Guilherme Curty Lechuga +5 more
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Nicastrin Deficiency Induces Tyrosinase-Dependent Depigmentation and Skin Inflammation [PDF]
Journal of Investigative Dermatology, 2020 Skin depigmentation diseases, such as vitiligo, are pigmentation disorders that often destroy melanocytes. However, their pathological mechanisms remain unclear, and therefore, promising treatments or prevention has been lacking. Here, we demonstrate that a zebrafish insertional mutant showing a significant reduction of nicastrin transcript possesses ...
Chia-Hao Hsu +2 more
openaire +2 more sources
Nicastrin guards Alzheimer’s gate [PDF]
Proceedings of the National Academy of Sciences, 2016 Alzheimer’s disease is characterized by protein deposits of amyloid-β as plaques in the brain (1). The suite of enzymes that produce amyloid-β by cutting it out of the amyloid-β precursor protein (APP) have long been considered to be prime targets for therapeutic intervention.
openaire +2 more sources
Crystal structure of the γ-secretase component nicastrin [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance γ-Secretase is a four-component intramembrane protease associated with the onset of Alzheimer's disease. Nicastrin is the putative substrate-recruiting component of the γ-secretase complex, but no atomic-resolution structure had been identified on γ-secretase or any of its four components.
Tian, Xie +8 more
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Neuartige Variante des NCSTN‐Gens bei einer Frau mit familiärer Hidradenitis suppurativa [PDF]
J Dtsch Dermatol GesJDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 10, Page 1332-1334, October 2025.
Hempel C +6 more
europepmc +2 more sources
P2‐314: Molecular studies of nicastrin in the γ‐Secretase complex using an artificial nicastrin independent presenilin 1 double mutant [PDF]
Alzheimer's & Dementia, 2011 Annelie Svensson +5 more
openalex +2 more sources
Molecular Metabolism, 2016 Objective: As the obesity pandemic continues to expand, novel molecular targets to reduce obesity-related insulin resistance and Type 2 Diabetes (T2D) continue to be needed.
David P. Sparling +6 more
doaj +1 more source
Structure of nicastrin unveils secrets of γ-secretase [PDF]
Proceedings of the National Academy of Sciences, 2014 Despite afflicting tens of millions worldwide, Alzheimer’s disease (AD) remains a devastating brain-destroying malady with no effective treatment or cure. A central hallmark of AD is the deposition of amyloid plaques in the brain. These plaques are primarily composed of the amyloid β-peptide (Aβ), a byproduct of proteolytic processing of the amyloid ...
David M, Bolduc, Michael S, Wolfe
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A Role for Presenilin 1 in Regulating the Delivery of Amyloid Precursor Protein to the Cell Surface
Neurobiology of Disease, 2002 Presenilin 1 (PS1) and presenilin 2 play a critical role in the γ-secretase processing of amyloid precursor protein (APP) and Notch1. Here, we investigate maturation and intracellular trafficking of APP and other membrane proteins in cells expressing an ...
Jae Yoon Leem +13 more
doaj +1 more source
Transcript‐Level Modulation of O‐GlcNAc Transferase for Aging‐Related Neurodegenerative Diseases [PDF]
ChembiochemO‐GlcNAc Transferase (OGT) and O‐GlcNAcase (OGA) maintain O‐GlcNAc homeostasis, but OGT expression and activity decline in the aging brain, promoting protein aggregation and neurodegeneration. Current approaches raise O‐GlcNAc levels via OGA inhibition. New insights into OGT splicing enable direct OGT upregulation using ASO‐ or PROTAC‐based strategies,
Malard F.
europepmc +2 more sources