Results 41 to 50 of about 3,289 (188)

Nicastrin: Gatekeeper of the γ-Secretase Complex [PDF]

Cell, 2005
The gamma-secretase intramembrane protease cleaves many type I membrane proteins including amyloid precursor protein and Notch, generating peptide fragments that are important signaling components. In this issue of Cell, Shah et al. (2005) reveal the function of nicastrin, the largest member of the gamma-secretase complex.
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Association of active γ-secretase complex with lipid rafts

Journal of Lipid Research, 2005
Cholesterol has been implicated in the pathogenesis of Alzheimer's disease (AD). Although the underlying mechanisms are not yet clear, several studies have provided evidence for the involvement of cholesterol-rich lipid rafts in the production of amyloid
Yasuomi Urano, Ikuo Hayashi, Noriko Isoo, Patrick C. Reid, Yoshikazu Shibasaki, Noriko Noguchi, Taisuke Tomita, Takeshi Iwatsubo, Takao Hamakubo, Tatsuhiko Kodama   +9 more
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Tau, APP, NCT and BACE1 in lymphocytes through cognitively normal ageing and neuropathology

Anais da Academia Brasileira de Ciências, 2013
Although Alzheimer's disease is a brain disorder, a number of peripheral alterations have been found in these patients; however, little is known about how the key genes involved in the pathophysiology express in peripheral cells such as lymphocytes ...
MARISOL HERRERA-RIVERO, ABRAHAM SOTO-CID, MARIA E. HERNaNDEZ, GONZALO E. ARANDA-ABREU   +3 more
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Hidradenitis Suppurativa: A Systematic Review Integrating Inflammatory Pathways Into a Cohesive Pathogenic Model

Frontiers in Immunology, 2018
Background: The pathogenesis of hidradenitis suppurativa (HS) is not fully understood. This systematic review examined the latest evidence for molecular inflammatory pathways involved in HS as a chronic inflammatory skin disease.Methods: A systematic ...
Allard R. J. V. Vossen, Hessel H. van der Zee, Errol P. Prens   +2 more
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Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo. [PDF]

PLoS ONE, 2011
Increase in the generation and deposition of amyloid-β (Aβ) plays a central role in the development of Alzheimer's Disease (AD). Elevation of the activity of γ-secretase, a key enzyme required for the generation for Aβ, can thus be a potential risk ...
Tong Li, Yue-Ming Li, Kwangwook Ahn, Donald L Price, Sangram S Sisodia, Philip C Wong   +5 more
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In silico Analysis of Gamma-Secretase-Complex Mutations in Hidradenitis Suppurativa Demonstrates Disease-Specific Substrate Recognition and Cleavage Alterations

Frontiers in Medicine, 2019
Background: Familial Hidradenitis Suppurativa and Familial Alzheimer's Disease are both associated with Gamma-Secretase Complex mutations; however, the two diseases are not epidemiologically associated. Understanding the molecular differences between the
John W. Frew, Kristina Navrazhina, Kristina Navrazhina   +2 more
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Magnesium Ions Inhibit the Expression of Tumor Necrosis Factor α and the Activity of γ-Secretase in a β-Amyloid Protein-Dependent Mechanism in APP/PS1 Transgenic Mice

Frontiers in Molecular Neuroscience, 2018
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by cognitive impairment. The neuropathological features of AD are the aggregation of extracellular amyloid β-protein (Aβ) and tau phosphorylation.
Xin Yu, Pei-Pei Guan, Di Zhu, Yun-Yue Liang, Tao Wang, Zhan-You Wang, Pu Wang   +6 more
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Maternal High Fat Diet Anticipates the AD-like Phenotype in 3xTg-AD Mice by Epigenetic Dysregulation of Aβ Metabolism

Cells, 2023
Maternal overnutrition has been reported to affect brain plasticity of the offspring by altering gene expression, regulating both synaptic plasticity and adult neurogenesis.
Francesca Natale, Matteo Spinelli, Marco Rinaudo, Sara Cocco, Ida Nifo Sarrapochiello, Salvatore Fusco, Claudio Grassi   +6 more
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The γ-secretase complex: from structure to function

Frontiers in Cellular Neuroscience, 2014
One of the most critical pathological features of Alzheimer’s disease (AD) is the accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain. Aβ is derived from β-amyloid precursor protein through sequential cleavage by β-
Xian eZhang, Yanfang eLi, Huaxi eXu, Huaxi eXu, Yun-Wu eZhang   +4 more
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Glu-333 of Nicastrin Directly Participates in γ-Secretase Activity [PDF]

Journal of Biological Chemistry, 2009
gamma-Secretase is a proteolytic membrane complex that processes a variety of substrates including the amyloid precursor protein and the Notch receptor. Earlier we showed that one of the components of this complex, nicastrin (NCT), functions as a receptor for gamma-secretase substrates.
Daniel R, Dries, Sanjiv, Shah, Yu-Hong, Han, Cong, Yu, Sophie, Yu, Mark S, Shearman, Gang, Yu   +6 more
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