Results 11 to 20 of about 256,874 (388)
Frontiers in Aging Neuroscience, 2020 Nicotinamide (vitamin B3) is a key component in the cellular production of Nicotinamide Adenine Dinucleotide (NAD) and has long been associated with neuronal development, survival and death.
Felipe Salech +12 more
doaj +2 more sources
Nicotinamide adenine dinucleotide is transported into mammalian mitochondria
eLife, 2018 Mitochondrial NAD levels influence fuel selection, circadian rhythms, and cell survival under stress. It has alternately been argued that NAD in mammalian mitochondria arises from import of cytosolic nicotinamide (NAM), nicotinamide mononucleotide (NMN),
Antonio Davila +9 more
doaj +2 more sources
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
Science, 2021 Anti-aging supplement effects in humans Synthesis of nicotinamide adenine dinucleotide (NAD+) decreases during aging, which is thought to limit the activity of enzymes that require it for their catalytic activity.
M. Yoshino +10 more
semanticscholar +1 more source
What is really known about the effects of nicotinamide riboside supplementation in humans
Science Advances, 2023 Nicotinamide riboside is a precursor to the important cofactor nicotinamide adenine dinucleotide and has elicited metabolic benefits in multiple preclinical studies.
Mads V. Damgaard, J. T. Treebak
semanticscholar +1 more source
Molecules, 2022 A nicotinamide-based derivative was designed as an antiproliferative VEGFR-2 inhibitor with the key pharmacophoric features needed to interact with the VEGFR-2 catalytic pocket.
E. Elkaeed +8 more
semanticscholar +1 more source
Complex roles of nicotinamide N-methyltransferase in cancer progression
Cell Death and Disease, 2022 Nicotinamide N-methyltransferase (NNMT) is an intracellular methyltransferase, catalyzing the N-methylation of nicotinamide (NAM) to form 1-methylnicotinamide (1-MNAM), in which S-adenosyl-l-methionine (SAM) is the methyl donor.
Weixuan Wang +3 more
semanticscholar +1 more source
Nicotinamide for the treatment of heart failure with preserved ejection fraction
Science Translational Medicine, 2021 The NAD+ precursor nicotinamide improves diastolic dysfunction caused by aging, hypertension, or metabolic syndrome in rodents. Diet and diastolic dysfunction Increasing nicotinamide adenine dinucleotide (NAD+) can mimic some of the benefits of caloric ...
M. Abdellatif +43 more
semanticscholar +1 more source
Antioxidants, 2021 Vitamin B3 (nicotinic acid, niacin) deficiency causes the systemic disease pellagra, which leads to dermatitis, diarrhea, dementia, and possibly death depending on its severity and duration.
Y. Boo
semanticscholar +1 more source
Nature Communications, 2021 With age, hematopoietic stem cells (HSC) undergo changes in function, including reduced regenerative potential and loss of quiescence, which is accompanied by a significant expansion of the stem cell pool that can lead to haematological disorders ...
Xuan Sun +25 more
semanticscholar +1 more source
Nicotinamide Improves Cognitive Function in Mice With Chronic Cerebral Hypoperfusion
Frontiers in Neurology, 2021 Normal brain function requires steady blood supply to maintain stable energy state. When blood supply to the brain becomes suboptimal for a long period of time, chronic cerebral hypoperfusion (CCH) and a variety of brain changes may occur.
Bin Liu +3 more
doaj +1 more source