Results 11 to 20 of about 132,023 (311)

Nicotinamide Improves Cognitive Function in Mice With Chronic Cerebral Hypoperfusion

Frontiers in Neurology, 2021
Normal brain function requires steady blood supply to maintain stable energy state. When blood supply to the brain becomes suboptimal for a long period of time, chronic cerebral hypoperfusion (CCH) and a variety of brain changes may occur.
Bin Liu, Guifeng Zhao, Ling Jin, Jingping Shi   +3 more
doaj   +1 more source

The Role of NAD⁺ in Metabolic Regulation of Adipose Tissue: Implications for Obesity-Induced Insulin Resistance

Biomedicines, 2023
Obesity-induced insulin resistance is among the key factors in the development of type 2 diabetes, atherogenic dyslipidemia and cardiovascular disease. Adipose tissue plays a key role in the regulation of whole-body metabolism and insulin sensitivity. In
Tatjana Ruskovska, David A. Bernlohr
doaj   +1 more source

Nicotinamide Deteriorates Post-Stroke Immunodepression Following Cerebral Ischemia–Reperfusion Injury in Mice

Biomedicines, 2023
(1) Background: Inducing experimental stroke leads to biphasic immune responses, where the early activation of immune functions is followed by severe immunosuppression accompanied by spleen and thymus atrophy.
Shih-Huang Tai, Liang-Chun Chao, Sheng-Yang Huang, Hsiao-Wen Lin, Ai-Hua Lee, Yi-Yun Chen, E-Jian Lee   +6 more
doaj   +1 more source

Amyotrophic lateral sclerosis and intestinal microbiota—toward establishing cause and effect

Gut Microbes, 2020
The intestinal microbiota may be involved, through metabolic gut–brain interactions, in a variety of neurological conditions. In this addendum, we summarize the findings of our recent study investigating the potentially modulatory influence of the ...
Marc Gotkine, Denise Kviatcovsky, Eran Elinav   +2 more
doaj   +1 more source

The Anion Impact on Dimensionality of Cadmium(II) Complexes with Nicotinamide

Chemistry, 2023
Three novel cadmium(II) coordination compounds, the dimeric [Cd(CH3COO)2(nia)2]2 (1), the polymeric {[Cd(nia)4](ClO4)2}n (2), and the monomeric [Cd(H2O)3(nia)3](ClO4)2·nia (3), were prepared in the reactions of the nicotinamide (pyridine-3-carboxamide ...
Željka Soldin, Boris-Marko Kukovec, Milica Kovačić, Marijana Đaković, Zora Popović   +4 more
doaj   +1 more source

Design and Activity of Novel Oxadiazole Based Compounds That Target Poly(ADP-ribose) Polymerase

Molecules, 2022
Novel PARP inhibitors with selective mode-of-action have been approved for clinical use. Herein, oxadiazole based ligands that are predicted to target PARP-1 have been synthesized and screened for the loss of cell viability in mammary carcinoma cells ...
Divakar Vishwanath, Swamy S. Girimanchanaika, Dukanya Dukanya, Shobith Rangappa, Ji-Rui Yang, Vijay Pandey, Peter E. Lobie, Basappa Basappa   +7 more
doaj   +1 more source

A Novel Peptide, Nicotinyl–Isoleucine–Valine–Histidine (NA–IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells

Marine Drugs, 2018
Nicotinamide (NA), a water-soluble vitamin B3, has been shown to exert cellular-protective effects against reactive oxygen species (ROS). In order to improve the cellular-protective effects of NA, we synthesized a novel compound, nicotinyl&ndash ...
Dong Hwee Son, Dong Joo Yang, Ji Su Sun, Seul Ki Kim, Namju Kang, Jung Yun Kang, Yun-Hee Choi, Jeong Hun Lee, Sang Hyun Moh, Dong Min Shin, Ki Woo Kim   +10 more
doaj   +1 more source

Topical nicotinamide in combination with calcipotriol for the treatment of mild to moderate psoriasis: A double-blind, randomized, comparative study

Advanced Biomedical Research, 2013
Background: Current treatment strategies of psoriasis are not completely satisfactorily. By inhibiting inflammatory cytokines, nicotinamide may enhance the effects of current topical treatments.
Amir Hossein Siadat, Fariba Iraji, Mehdi Khodadadi, Maryam Kalateh Jary   +3 more
doaj   +1 more source

The Prospective Synergy of Antitubercular Drugs With NAD Biosynthesis Inhibitors

Frontiers in Microbiology, 2021
Given the upsurge of drug-resistant tuberculosis worldwide, there is much focus on developing novel drug combinations allowing shorter treatment duration and a lower toxicity profile.
Kyle H. Rohde, Leonardo Sorci
doaj   +1 more source

Dissolution Enhancement of Atorvastatin Calcium by Cocrystallization [PDF]

Advanced Pharmaceutical Bulletin, 2019
Purpose: To enhance the dissolution rate of the poorly soluble drug atorvastatin calcium (ATC) by cocrystallization with selected coformers. Enhancement of the dissolution rate and solubility of the drug, which is classified as Class II of the ...
Reham Al-Kazemi, Yacoub Al-Basarah, Aly Nada   +2 more
doaj   +1 more source