Poly(amido amine)s as Gene Delivery Vectors: Effects of Quaternary Nicotinamide Moieties in the Side Chains [PDF]
, 2008 To evaluate the effect of quaternary nicotinamide pendant groups on gene delivery properties, a series of poly(amido amine) (co)polymers were synthesized by Michael addition polymerization of N, N-cystaminebisacrylamide with variable ratios of 1-(4 ...
Engbersen, Johan F.J. +4 more
core +6 more sources
Biomedicines, 2023 Obesity-induced insulin resistance is among the key factors in the development of type 2 diabetes, atherogenic dyslipidemia and cardiovascular disease. Adipose tissue plays a key role in the regulation of whole-body metabolism and insulin sensitivity. In
Tatjana Ruskovska, David A. Bernlohr
doaj +1 more source
It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]
, 2016 The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
core +2 more sources
Biomedicines, 2023 (1) Background: Inducing experimental stroke leads to biphasic immune responses, where the early activation of immune functions is followed by severe immunosuppression accompanied by spleen and thymus atrophy.
Shih-Huang Tai +6 more
doaj +1 more source
Resveratrol mediated modulation of Sirt-1/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: potential role of Runx2 deacetylation. [PDF]
, 2012 Osteogenic repair in response to bone injury is characterized by activation and differentiation of mesenchymal stem cells (MSCs) to osteoblasts.
Aldinger, Constance +6 more
core +5 more sources
The Anion Impact on Dimensionality of Cadmium(II) Complexes with Nicotinamide
Chemistry, 2023 Three novel cadmium(II) coordination compounds, the dimeric [Cd(CH3COO)2(nia)2]2 (1), the polymeric {[Cd(nia)4](ClO4)2}n (2), and the monomeric [Cd(H2O)3(nia)3](ClO4)2·nia (3), were prepared in the reactions of the nicotinamide (pyridine-3-carboxamide ...
Željka Soldin +4 more
doaj +1 more source
Amyotrophic lateral sclerosis and intestinal microbiota—toward establishing cause and effect
Gut Microbes, 2020 The intestinal microbiota may be involved, through metabolic gut–brain interactions, in a variety of neurological conditions. In this addendum, we summarize the findings of our recent study investigating the potentially modulatory influence of the ...
Marc Gotkine +2 more
doaj +1 more source
Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B2) in aqueous solution [PDF]
, 2006 The effect of caffeine (CAF) and nicotinamide (NMD) on the solubility of a vitamin B2 derivative (FMN) has been evaluated for mixtures containing either a single hydrotrope (CAF or NMD) or the two hydrotropes simultaneously.
A.A. Hernandez Santiago +22 more
core +1 more source
Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding [PDF]
, 2016 Funding: The Scottish Government's Rural and Environment Science and Analytical Services Division.Peer ...
Drew, Janice E. +3 more
core +1 more source
Design and Activity of Novel Oxadiazole Based Compounds That Target Poly(ADP-ribose) Polymerase
Molecules, 2022 Novel PARP inhibitors with selective mode-of-action have been approved for clinical use. Herein, oxadiazole based ligands that are predicted to target PARP-1 have been synthesized and screened for the loss of cell viability in mammary carcinoma cells ...
Divakar Vishwanath +7 more
doaj +1 more source