Results 1 to 10 of about 134,103 (347)

Nicotinamide adenine dinucleotide and the sirtuins caution: Pro-cancer functions. [PDF]

Aging Med (Milton), 2021
This scoping review aims to perform a brief but comprehensive assessment of existing peer‐reviewed literature and determine whether raising nicotinamide adenine dinucleotide can prevent or promote tumorigenesis. The examination of extensive peer‐reviewed
Palmer RD, Vaccarezza M.
europepmc   +4 more sources

Molecular properties and regulation of NAD+ kinase (NADK)

Redox Biology, 2023
Nicotinamide adenine dinucleotide (NAD+) kinase (NADK) phosphorylates NAD+, thereby producing nicotinamide adenine dinucleotide phosphate (NADP). Both NADK genes and the NADP(H)-producing mechanism are evolutionarily conserved among archaea, bacteria ...
Shin-ichi Oka, Allen Sam Titus, Daniela Zablocki, Junichi Sadoshima   +3 more
doaj   +1 more source

Remote Limb Ischemic Postconditioning Protects Against Ischemic Stroke by Promoting Regulatory T Cells Thriving

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Remote limb ischemic postconditioning (RLIPoC) has been demonstrated to protect against ischemic stroke. However, the underlying mechanisms of RLIPoC mediating cross‐organ protection remain to be fully elucidated.
Hai‐Han Yu, Xiao‐Tong Ma, Xue Ma, Man Chen, Yun‐Hui Chu, Long‐Jun Wu, Wei Wang, Chuan Qin, Dai‐Shi Tian   +8 more
doaj   +1 more source

Progress in research on mechanism of nicotinamide adenine dinucleotide and its precursors against aging-related diseases

Zhongguo gonggong weisheng, 2023
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme of various dehydrogenases, which plays an important role in physiological processes such as glycolysis and tricarboxylic acid cycle.
Shixiong ZHENG, Jing LÜ, Shentao GUO, Xingfen YANG, Zhini HE   +4 more
doaj   +1 more source

Niacin – a scoping review for Nordic Nutrition Recommendations 2023

Food & Nutrition Research, 2023
Niacin is the precursor to pyridine nucleotides NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate). Niacin (vitamin B3) is the common term for nicotinic acid, nicotinamide and derivatives that exhibit the ...
Riitta Freese, Vegard Lysne
doaj   +1 more source

Novel GSK-3β Inhibitor Neopetroside A Protects Against Murine Myocardial Ischemia/Reperfusion Injury

JACC: Basic to Translational Science, 2022
Summary: Recent trends suggest novel natural compounds as promising treatments for cardiovascular disease. The authors examined how neopetroside A, a natural pyridine nucleoside containing an α-glycoside bond, regulates mitochondrial metabolism and heart
Hyoung Kyu Kim, PhD, Min Kim, PhD, Jubert C. Marquez, PhD, Seung Hun Jeong, PhD, Tae Hee Ko, PhD, Yeon Hee Noh, MS, Pham Trong Kha, PhD, Ha Min Choi, BS, Dong Hyun Kim, PhD, Jong Tae Kim, PhD, Young Il Yang, PhD, Kyung Soo Ko, PhD, Byoung Doo Rhee, PhD, Larisa K. Shubina, PhD, Tatyana N. Makarieva, PhD, Dmitry Y. Yashunsky, PhD, Alexey G. Gerbst, PhD, Nikolay E. Nifantiev, PhD, Valentin A. Stonik, PhD, Jin Han, PhD   +19 more
doaj   +1 more source

Circulating blood eNAMPT drives the circadian rhythms in locomotor activity and energy expenditure

Nature Communications, 2023
Nicotinamide phosphoribosyl transferase (NAMPT) is a critical regulator of cellular nicotinamide adenine dinucleotide (NAD)+ levels. Here, the authors show that blood NAMPT contributes to the circadian rhythm generation of locomotor activity and energy ...
Jae Woo Park, Eun Roh, Gil Myoung Kang, So Young Gil, Hyun Kyong Kim, Chan Hee Lee, Won Hee Jang, Se Eun Park, Sang Yun Moon, Seong Jun Kim, So Yeon Jeong, Chae Beom Park, Hyo Sun Lim, Yu Rim Oh, Han Na Jung, Obin Kwon, Byung Soo Youn, Gi Hoon Son, Se Hee Min, Min-Seon Kim   +19 more
doaj   +1 more source

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity [PDF]

Diabetes & Metabolism Journal, 2014
The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and ...
In-Kyu Lee
doaj   +1 more source

Enzymology of Ca²⁺-Mobilizing Second Messengers Derived from NAD: From NAD Glycohydrolases to (Dual) NADPH Oxidases

Cells, 2023
Nicotinamide adenine dinucleotide (NAD) and its 2′-phosphorylated cousin NADP are precursors for the enzymatic formation of the Ca2+-mobilizing second messengers adenosine diphosphoribose (ADPR), 2′-deoxy-ADPR, cyclic ADPR, and nicotinic acid adenine ...
Andreas H. Guse
doaj   +1 more source

The role of nicotinamide-β-adenine dinucleotide phosphate-H-cytochrome P450 oxidoreductase in the activation of cytochromes [PDF]

BIO Web of Conferences
The aim of this theoretical study is to investigate the mechanisms of action of these enzymes in the context of metabolism in highly productive animals.
Popova Olga, Bylinskaya Daria, Nikitina Anastasia, Ukrainskaya Olga   +3 more
doaj   +1 more source