Results 101 to 110 of about 142,436 (357)

Nicotinamide adenine dinucleotide suppresses epileptogenesis at an early stage

Scientific Reports, 2017
The pathophysiologic mechanisms of epileptogenesis are poorly understood, and no effective therapy exists for suppressing epileptogenesis. Numerous reports have shown that nicotinamide adenine dinucleotide (NAD+) has neuroprotective effects, suggesting ...
Juan Liu, Beimeng Yang, Pei Zhou, Yingying Kong, Weiwei Hu, Geng Zhu, Weihai Ying, Weidong Li, Yun Wang, Shengtian Li   +9 more
doaj   +1 more source

The processes of the catalytic cycle of the cytochrome system associated with its activation by means of the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase [PDF]

BIO Web of Conferences
The paper presents a theoretical study of the molecular mechanism of activation of the cytochrome P450 system by the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase in the catalytic cycle.
Popova Olga, Bylinskaya Daria, Nikitina Anastasia, Ukrainskaya Olga   +3 more
doaj   +1 more source

Insight into an Oxidative DNA-Cleaving DNAzyme: Multiple Cofactors, the Catalytic Core Map and a Highly Efficient Variant

iScience, 2020
Summary: An oxidative DNA-cleaving DNAzyme (PL) employs a double-cofactor model “X/Cu2+” for catalysis. Herein, we verified that reduced nicotinamide adenine dinucleotide (NADH), flavin mononucleotide, cysteine, dithiothreitol, catechol, resorcinol ...
Wenqian Yu, Shijin Wang, Dongling Cao, Hongyue Rui, Chengcheng Liu, Yongjie Sheng, Yanhong Sun, Jin Zhang, Jiacui Xu, Dazhi Jiang   +9 more
doaj   +1 more source

Inhibition of Nicotinamidase by Nicotinamide Adenine Dinucleotide

Journal of Biological Chemistry, 1971
Abstract Feedback inhibition by NAD was shown with the nicotinamidases of a number of microorganisms. The purified enzyme from Fleischmann's yeast was found to have a molecular weight of 110,000 and consist of presumably identical subunits with a molecular weight of 26,000.
D F, Calbreath, J G, Joshi
openaire   +2 more sources

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Oxidative Stress in Human Aorta of Patients with Advanced Aortoiliac Occlusive Disease

Brazilian Journal of Cardiovascular Surgery
Introduction: Oxidative stress seems to be a role in the atherosclerosis process, but research in human beings is scarce. Objective: To evaluate the role of oxidative stress on human aortas of patients submitted to surgical treatment for advanced ...
Márcio Luís Lucas, Cristina Campos Carraro, Adriane Belló-Klein, Antonio Nocchi Kalil, Newton Aerts   +4 more
doaj   +1 more source

Is there an interplay between adherence to mediterranean diet, antioxidant status, and vascular disease in atrial fibrillation patients? [PDF]

, 2015
Mediterranean Diet (Med-Diet) is associated with reduced incidence of vascular events (VEs) in atrial fibrillation (AF), but the mechanism accounting for its beneficial effect is only partially known.
PASTORI, DANIELE, CARNEVALE, Roberto, MENICHELLI, DANILO, NOCELLA, CRISTINA, BARTIMOCCIA, SIMONA, NOVO, MARTA, Leo, Isabella, VIOLI, Francesco, PIGNATELLI, Pasquale   +8 more
core   +4 more sources

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Cloning, expression and characterization of alcohol dehydrogenases in the silkworm Bombyx mori

Genetics and Molecular Biology, 2011
Alcohol dehydrogenases (ADH) are a class of enzymes that catalyze the reversible oxidation of alcohols to corresponding aldehydes or ketones, by using either nicotinamide adenine dinucleotide (NAD) or nicotinamide adenine dinucleotide phosphate (NADP ...
Nan Wang, Haifeng Shi, Qin Yao, Yang Zhou, Lequn Kang, Huiqin Chen, Keping Chen   +6 more
doaj   +1 more source

Biofilm development in a fluidized bed bioreactor for aerobic phenol degradation : a thesis presented in partial fulfilment of the requirements for the degree of Master of Technology in Biotechnology and Bioprocess Engineering at Massey University [PDF]

, 1993
The main objective of this thesis was to follow the biofilm development during start-up of a fluidized bed biorcactor with the help of digital image processing.
Maushake, Kirsten
core