Results 111 to 120 of about 13,531,604 (176)

Development of a Suicide Inhibition-Based Protein Labeling Strategy for Nicotinamide N‑Methyltransferase

, 2019
Nicotinamide N-methyltransferase (NNMT) catalyzes the S-adenosyl-l-methionine-dependent methylation of nicotinamide to form N-methylnicotinamide. This enzyme detoxifies xenobiotics and regulates NAD+ biosynthesis.
Eranthie Weerapana (1377093), Walter Fast, Ari J. Salinger, Santanu Mondal, Li Zheng, Eranthie Weerapana, Santanu Mondal (3113793), Paul R. Thompson (105487), Li Zheng (15952), Walter Fast (1264839), Sudeshna Sen (1845961), Paul R. Thompson, Sudeshna Sen, Ari J. Salinger (2910698)   +13 more
core   +1 more source

Nicotinamide N-Methyltransferase [PDF]

, 2020
openaire   +1 more source

Self-amplifying nicotinamide N-methyltransferase feedback loops: Drivers of anticancer drug resistance and therapeutic opportunities

Journal of Pharmaceutical Analysis
Drug resistance poses a significant challenge in cancer therapy, undermining treatment efficacy and patient survival. Nicotinamide N-methyltransferase (NNMT), a pivotal cytoplasmic enzyme, plays a crucial role in mediating drug resistance by linking ...
Shuang-Zhou Bi, Xiang-Li Ni, Wei-Dong Sun, Chen-Ying Zhang, An Liu, Shi-Yan Lai, Jiang-Hua Li   +6 more
doaj   +1 more source

Nicotinamide N-methyltransferase (NNMT) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Nicotinamide N-methyltransferase (NNMT) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Preliminary investigation of nicotinamide N-methyltransferase as an HBV-specific biomarker for hepatocellular carcinoma diagnosis

The International Journal of Biological Markers
Background Nicotinamide N-methyltransferase (NNMT), a metabolic enzyme in the liver, has been implicated in various biological processes, and its high expression in hepatocellular carcinoma has been linked to tumor metastasis and poor prognosis. However,
Yi Zhang, Huayang Chen, Song You, Xiaoqin Chi, Yongxi Chen, Zhiyong Wu, Jiepeng Zheng, Xin Cheng, Jianming Liu, Jie Li   +9 more
doaj   +1 more source

Nicotinamide N-methyltransferase mediates lipofibroblast-myofibroblast transition and apoptosis resistance. [PDF]

J Biol Chem, 2023
Rehan M, Deskin B, Kurundkar AR, Yadav S, Matsunaga Y, Manges J, Smith N, Dsouza KG, Burow ME, Thannickal VJ.   +9 more
europepmc   +1 more source

Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization

, 2015
Nicotinamide N-methyltransferase (Nnmt) methylates nicotinamide, a form of vitamin B3, to produce N1-methylnicotinamide (MNAM). Nnmt has emerged as a metabolic regulator in adipocytes, but its role in the liver, the tissue with the strongest Nnmt ...
Deepthi Prasad, Yoonjin Lee, Lee, Yoonjin, Wei, Xiaojing, Tzameli, Iphigenia, Pavlos Pissios, Jose M Moreno-Navarrete, Shangyu Hong, Xiaojing Wei, Hong, Shangyu, Jose Manuel Fernandez-Real, Eleftheria Maratos-Flier, Pissios, Pavlos, Fernández-Real Lemos, José Manuel, Prasad, Deepthi, Iphigenia Tzameli, Asara, John M., Maratos-Flier, Eleftheria, Moreno Navarrete, José María, John M Asara, Kikukawa, Yusuke, Yusuke Kikukawa   +21 more
core   +1 more source

Nicotinamide N-Methyltransferase upregulation correlates with tumour differentiation in oral squamous cell carcinoma [PDF]

, 2010
We investigated expression levels of Nicotinamide N-Methyltransferase (NNMT), an enzyme involved in the biotransformation of many drugs and xenobiotic compounds, in oral squamous cell carcinoma (OSCC).
EMANUELLI, Monica, RUBINI, Corrado, Lo Muzio L., Sartini, Davide, Rossi, Valentina, SANTARELLI, Andrea, Lo Muzio, L., POZZI, VALENTINA, Ciavarella, Domenico, SARTINI, Davide, Rossi V., Rubini, C., Ciavarella D.   +12 more
core  

Nicotinamide N-methyltransferase sustains a core epigenetic program that promotes metastatic colonization in breast cancer. [PDF]

EMBO J, 2023
Couto JP, Vulin M, Jehanno C, Coissieux MM, Hamelin B, Schmidt A, Ivanek R, Sethi A, Bräutigam K, Frei AL, Hager C, Manivannan M, Gómez-Miragaya J, Obradović MM, Varga Z, Koelzer VH, Mertz KD, Bentires-Alj M.   +17 more
europepmc   +1 more source