Results 121 to 130 of about 13,531,604 (176)

Synthesis of [11C]nicotinamide analogs for imaging of nicotinamide N‑methyltransferase activity

, 2019
Objectives Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide and various closely related structural analogs to form positively charged pyridinium ions and contributes to the nicotinamide clearance and xenobiotic ...
Ishii, Hideki, Ming-Rong, Zhang, Wakizaka, Hidekatsu, Okada, Maki, 765277, 765278, 765279, 765273, 765274, 765275, 765276, 765280, Okamura, Toshimitsu, 765281, 765282, 765272, 765283, Kikuchi, Tatsuya   +17 more
core  

Management of nicotinamide N-methyltransferase overexpression: inhibit the enzyme or reduce nicotinamide intake? [PDF]

Diabetologia, 2015
Shi-Sheng, Zhou, Da, Li, Yiming, Zhou
openaire   +2 more sources

Synthesis of [11C]nicotinamide analogs for imaging of nicotinamide N‑methyltransferase activity

Synthesis of [11C]nicotinamide analogs for imaging of nicotinamide N‑methyltransferase activity
Objectives Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide and various closely related structural analogs to form positively charged pyridinium ions and contributes to the nicotinamide clearance and xenobiotic detoxification. NNMT is expressed primarily in the liver but has been found in other tissues at lower levels.
openaire   +1 more source

Nicotinamide N-methyltransferase enhances paclitaxel resistance in ovarian clear cell carcinoma. [PDF]

Hum Cell
Kikuchi-Koike R, Sakamoto M, Sasajima Y, Miyagawa Y, Uozaki H, Umayahara K, Hashimoto K, Takahashi Y, Takasaki K, Kihira C, Nishida H, Ichinose T, Hirano M, Hiraike H, Nagasaka K.   +14 more
europepmc   +1 more source

Prognostic and Therapeutic Potential of Nicotinamide N-Methyltransferase and Hypoxia Inducible Lipid Droplet Associated in Clear Cell Renal Cell Carcinoma. [PDF]

J Korean Med Sci
Kim M, Song G, Joung JY, Seo HK, Lee HH, Chung J.   +5 more
europepmc   +1 more source

Exploring Unconventional SAM Analogues To Build Cell-Potent Bisubstrate Inhibitors for Nicotinamide N-Methyltransferase. [PDF]

Angew Chem Int Ed Engl, 2022
Iyamu ID, Vilseck JZ, Yadav R, Noinaj N, Huang R.   +4 more
europepmc   +1 more source

High Expression of Nicotinamide N-Methyltransferase in Patients with Sporadic Alzheimer's Disease. [PDF]

Mol Neurobiol, 2021
Kocinaj A, Chaudhury T, Uddin MS, Junaid RR, Ramsden DB, Hondhamuni G, Klamt F, Parsons L, Parsons RB.   +8 more
europepmc   +1 more source

Nicotinamide N-Methyltransferase Inhibition Mitigates Cerulein-Induced Pancreatic Fibrosis via Galectin-3-Mediated Regulation of Stellate Cell Activation and Macrophage M2 Polarization in Mice. [PDF]

Inflammation
Ren N, Li R, Tao Q, Hong S, Wang J, Zha J, Wang S, Zhang G.   +7 more
europepmc   +1 more source

Linkage of nanosecond protein motion with enzymatic methyl transfer by nicotinamide N-methyltransferase. [PDF]

Turk J Biol, 2021
Jing Y, Cheng Y, Li F, Li Y, Liu F, Zhang J.   +5 more
europepmc   +1 more source

Nicotinamide N-methyltransferase upregulation contributes to palmitate-elicited peroxisome proliferator-activated receptor transactivation in hepatocytes.

Am J Physiol Cell Physiol, 2023
Song Q, Wang J, Griffiths A, Lee SM, Iyamu ID, Huang R, Cordoba-Chacon J, Song Z.   +7 more
europepmc   +1 more source