Results 101 to 110 of about 13,531,604 (176)

Selective N‐Functionalization of Pyrazoles

European Journal of Organic Chemistry, Volume 29, Issue 40, 27 October 2026.
This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek, Matthias Schrader, Christopher J. Teskey   +2 more
wiley   +1 more source

Bisubstrate Inhibitors of Nicotinamide N‑Methyltransferase (NNMT) with Enhanced Activity

, 2019
Nicotinamide N-methyltransferase (NNMT) catalyzes the methylation of nicotinamide to form N-methylnicotinamide. Overexpression of NNMT is associated with a variety of diseases, including a number of cancers and metabolic disorders, suggesting a role for ...
Alessia Salvucci (6949316), Matthijs J. van Haren (7314779), Ed E. Moret (1822108), Monica Emanuelli (353762), Johannes J. M. Rood (5842712), Pierrick Craveur (6949319), Yongzhi Gao (6949313), Nathaniel I. Martin (847378), Davide Sartini (353765), Nicolas Babault (2742730), Jian Jin (351142)   +10 more
core   +2 more sources

Nicotinamide N-methyltransferase catalyses the N-methylation of the endogenous β-carboline norharman: evidence for a novel detoxification pathway [PDF]

, 2016
Nicotinamide N-methyltransferase (NNMT) is responsible for the N-methylation of nicotinamide to 1-methylnicotinamide. Our recent studies have demonstrated that NNMT regulates cellular processes fundamental to the correct functioning and survival of the ...
Ramsden, Db, van Haren, Matthijs J, Martin, Ni, Thomas, M.G., Martin, Nathaniel I., Mountford, D.M., Barlow, David John; id_orcid, Barlow, David J, Ramsden, David B, Parsons, Richard Bramwell, Barlow, Dj, Emanuelli, Monica, Thomas, Martin G, Mountford, David M, Mountford, David Mark, Ramsden, D.B., Klamt, F, Medicinal Chemistry and Chemical Biology, Reza, M, Barlow, D.J., Martin, Nathaniel I, Haren, M.J. van, Martin, N.I., Klamt, Fábio, Sartini, D., Emanuelli, M., Parsons, Richard B, Thomas, Mg, van Haren, Mj, Parsons, R.B., Ramsden, David B., Parsons, Rb, Reza, Madeehah, Klamt, F., Sartini, Davide, Van Haren, Matthijs J., Mountford, Dm, Reza, M.   +37 more
core   +1 more source

Nicotinamide N-Methyltransferase Suppression Participates in Nickel-Induced Histone H3 Lysine9 Dimethylation in BEAS-2B Cells

Cellular Physiology and Biochemistry, 2017
Background: Nickel compounds are well-established human carcinogens with weak mutagenic activity. Histone methylation has been proposed to play an important role in nickel-induced carcinogenesis.
Qian Li, Min-Di He, Lin Mao, Xue Wang, Yu-Lin Jiang, Min Li, Yong-Hui  Lu, Zheng-Ping Yu, Zhou Zhou   +8 more
doaj   +1 more source

Nicotinamide N-Methyltransferase Expression in Cervical Adenocarcinoma and Its Clinical Significance

Indian Journal of Gynecologic Oncology, 2019
Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme increasingly implicated in tumor progression and resistance to treatment. It is overexpressed in human cancers including glioblastoma, gastric, pancreatic, lung and colorectal cancers. The role of NNMT in cervical adenocarcinoma has not been studied thus far.
Serra Akar, İsmail Harmankaya, Serdar Uğraş, Ersin Çintesun, Çetin Çelik   +4 more
openaire   +2 more sources

Targeting nicotinamide N‐methyltransferase decreased aggressiveness of osteosarcoma cells

European Journal of Clinical Investigation
AbstractBackgroundOsteosarcoma (OS) is a primary bone malignancy that mostly affects young people, characterized by high metastatic potential, and a marked chemoresistance that is responsible for disease relapse in most patients. Therefore, it is necessary to identify novel molecules to setup targeted strategies to improve the clinical outcome.
Serritelli, E.N., Sartini, D., Campagna, R., Pozzi, V., Martin, N.I., Haren, M.J. van, Salvolini, E., Cecati, M., Rubini, C., Emanuelli, M.   +9 more
openaire   +3 more sources

Nicotinamide N -Methyltransferase: More Than a Vitamin B3 Clearance Enzyme [PDF]

Trends in Endocrinology & Metabolism, 2017
Nicotinamide (NAM) N-methyltransferase (NNMT) was originally identified as the enzyme responsible for the methylation of NAM, one of the forms of vitamin B3. Methylated NAM is eventually excreted from the body. Recent evidence has expanded the role of NNMT beyond clearance of excess vitamin B3.
openaire   +2 more sources

SNORA13 antisense oligonucleotides enhances the therapeutical effects of 5-fluorouracil in colon adenocarcinoma

Frontiers in Pharmacology
IndroductionColorectal cancer (CRC) is a prevalent malignancy and is the second leading cause of cancer-related mortality worldwide. 5-Fluorouracil (5-FU) is widely used in clinical intervention, however, drug resistance to 5-FU poses a significant ...
Yanzhi Wang, Huihui An, Yaou Zhang, Yaou Zhang, Qing Rex Lyu, Zhe Zhang   +5 more
doaj   +1 more source

Elevated N‐methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 isoform

Molecular Oncology, 2019
The cross‐talk between hepatic stellate cells (HSCs) and hepatic carcinoma cells contributes to hepatocellular carcinoma (HCC) progression, but the underlying mechanism is largely unknown.
Jie Li, Song You, Sheng Zhang, Qing Hu, Fuqiang Wang, Xiaoqin Chi, Wenxiu Zhao, Chengrong Xie, Changmao Zhang, Yaqi Yu, Jianmin Liu, Yue Zhao, Pingguo Liu, Yi Zhang, Xujin Wei, Qiu Li, Xiaomin Wang, Zhenyu Yin   +17 more
doaj   +1 more source

Kinetic Mechanism of Nicotinamide N‑Methyltransferase

, 2018
Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, pyridine, and other structural analogues.
Paul R. Thompson (105487), Heather S. Loring, Heather S. Loring (5732732), Paul R. Thompson   +3 more
core   +1 more source