Results 41 to 50 of about 57,446 (263)

Inhibition of Nicotinamide Phosphoribosyltransferase [PDF]

Journal of Biological Chemistry, 2010
Maria Gloria Pittelli, Laura Formentini, Giuseppe Faraco, Andrea Lapucci, Elena Rapizzi, Francesca Cialdai, G. Romano, Gloriano Moneti, Flavio Moroni, Alberto Chiarugi   +9 more
openalex   +3 more sources

Crystallization of human nicotinamide phosphoribosyltransferase [PDF]

Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2007
In the NAD biosynthetic pathway, nicotinamide phosphoribosyltransferase (NMPRTase; EC 2.4.2.12) plays an important role in catalyzing the synthesis of nicotinamide mononucleotide from nicotinamide and 5'-phosphoribosyl-1'-pyrophosphate. Because the diffraction pattern of the initially obtained crystals was not suitable for structure analysis, the ...
Ryo Takahashi, Shota Nakamura, Takuya Yoshida, Yuji Kobayashi, Tadayasu Ohkubo   +4 more
openalex   +4 more sources

Cardioprotective Effects of 1-(3,6-Dibromo-carbazol-9-yl)-3-Phenylamino-Propan-2-Ol in Diabetic Hearts via Nicotinamide Phosphoribosyltransferase Activation. [PDF]

J Pharmacol Exp Ther, 2022
Tur J, Badole SL, Manickam R, Chapalamadugu KC, Xuan W, Guida W, Crews JJ, Bisht KS, Tipparaju SM.   +8 more
europepmc   +2 more sources

Nicotinamide phosphoribosyltransferase inhibitors, design, preparation and SAR. [PDF]

Journal of Medicinal Chemistry, 2013
Existing pharmacological inhibitors for nicotinamide phosphoribosyltransferase (NAMPT) are promising therapeutics for treating cancer. Using medicinal and computational chemistry methods, the structure-activity relationship for novel classes of NAMPT inhibitors is described and compounds optimized. Compounds are designed inspired by the NAMPT inhibitor
Annemette Thougaard, Antje Garten, Beauparlant P., Becke A. D., Becke A. D., Binderup E., Butera J. A., Cea M., Colombano G., Deraeve C., Diefenbach J., Ditchfield R., Einars Loza, Elliott G. C., Elstner M., Fleischer T. C., Foster J. W., Fredrik Björkling, Galli U., Garten A., Genazzani A. A., Grimme S., Gross J. W., Hageman G. J., Hasmann M., Holen K., Hovstadius P., Hufton S. E., Humljan J., Ivars Kalvinsh, Jette Tjørnelund, Kamille D. Erichsen, Khan J. A., Khan J. A., Kim M. K., Kornet M. J., Lee C., Lengauer C., Linderoth L., Magni G., Malavasi F., Maxwell Sehested, Mette K. Christensen, Nahimana A., Natarajan A., Nomura F., Olesen U. H., Olesen U. H., Olesen U. H., Orwig K. S., Peter B. Jensen, Peter Fristrup, Preiss J., Preiss J., Rongvaux A., Saunders L. R., Schou C., Shackelford R. E., Skelton L. A., Søren Jensby Nielsen, Uffe H. Olesen, van Beijnum J. R., Wang B., Watson M., Wieland Kiess, Zhao X., Ziegler M.   +66 more
core   +6 more sources

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

NAMPT (nicotinamide phosphoribosyltransferase) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on NAMPT (nicotinamide phosphoribosyltransferase), with data on DNA, on the protein encoded, and where the gene is implicated.
Koumaki, V, Dalamaga, M
openaire   +2 more sources

Biosynthesis of Nicotinamide Mononucleotide: Current Metabolic Engineering Strategies, Challenges, and Prospects

Fermentation, 2023
Nicotinamide mononucleotide (NMN) is an essential precursor of nicotinamide adenine dinucleotide (NAD+), which is widely applied in the pharmaceutical and biotech industries.
Shiqi Luo, Juntao Zhao, Yangyang Zheng, Tao Chen, Zhiwen Wang   +4 more
doaj   +1 more source

Synthesis and structure-activity relationship of new nicotinamide phosphoribosyltransferase inhibitors with antitumor activity on solid and haematological cancer

European journal of medicinal chemistry, 2023
Simone Fratta, Paulina Biniecka, Antonio J. Moreno‐Vargas, Ana T. Carmona, Aimable Nahimana, Michel A. Duchosal, Francesco Piacente, Santina Bruzzone, Irene Caffa, Alessio Nencioni, Inmaculada Robina   +10 more
openalex   +3 more sources

It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]

, 2016
The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
core   +5 more sources

Insights into the NAD+ biosynthesis pathways involved during meiotic maturation and spindle formation in porcine oocytes

The Journal of Reproduction and Development, 2022
Treatments that elevate NAD+ levels have been found to improve oocyte quality in mice, cattle, and pigs, suggesting that NAD+ is vital during oocyte maturation.
Charley-Lea POLLARD, Ashleigh YOUNAN, Aleona SWEGEN, Zamira GIBB, Christopher G. GRUPEN   +4 more
doaj   +1 more source