Results 41 to 50 of about 51,366 (193)

Properly Substituted Benzimidazoles as a New Promising Class of Nicotinate Phosphoribosyltransferase (NAPRT) Modulators

Pharmaceuticals, 2023
The prevention of nicotinamide adenine dinucleotide (NAD) biosynthesis is considered an attractive therapeutic approach against cancer, considering that tumor cells are characterized by an increased need for NAD to fuel their reprogrammed metabolism.
Cecilia Baldassarri, Gianfabio Giorgioni, Alessandro Piergentili, Wilma Quaglia, Stefano Fontana, Valerio Mammoli, Gabriele Minazzato, Elisa Marangoni, Massimiliano Gasparrini, Leonardo Sorci, Nadia Raffaelli, Loredana Cappellacci, Riccardo Petrelli, Fabio Del Bello   +13 more
doaj   +1 more source

Nicotinamide phosphoribosyltransferase/visfatin does not catalyze nicotinamide mononucleotide formation in blood plasma. [PDF]

PLoS ONE, 2011
Nicotinamide (Nam) phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in mammalian NAD synthesis, catalyzing nicotinamide mononucleotide (NMN) formation from Nam and 5-phosphoribosyl 1-pyrophosphate (PRPP).
Nobumasa Hara, Kazuo Yamada, Tomoko Shibata, Harumi Osago, Mikako Tsuchiya   +4 more
doaj   +1 more source

From Rate-Limiting Enzyme to Therapeutic Target: The Promise of NAMPT in Neurodegenerative Diseases

Frontiers in Pharmacology, 2022
Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD) salvage pathway in mammals. It is of great significance in the metabolic homeostasis and cell survival via synthesizing nicotinamide
Yumeng Zhu, Ping Xu, Xuan Huang, Wen Shuai, Li Liu, Shuai Zhang, Rui Zhao, Xiuying Hu, Guan Wang   +8 more
doaj   +1 more source

Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD

Biomolecules, 2021
It has recently been demonstrated that the rat poison vacor interferes with mammalian NAD metabolism, because it acts as a nicotinamide analog and is converted by enzymes of the NAD salvage pathway. Thereby, vacor is transformed into the NAD analog vacor
Lars Jansen Sverkeli, Faisal Hayat, Marie E. Migaud, Mathias Ziegler   +3 more
doaj   +1 more source

The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells

Haematologica, 2012
Background Inhibitors of nicotinamide phosphoribosyltransferase have recently been validated as therapeutic targets in leukemia, but the mechanism of leukemogenic transformation downstream of this enzyme is unclear.Design and Methods Here, we evaluated ...
Lan Dan, Olga Klimenkova, Maxim Klimiankou, Jan-Henning Klusman, Marry M. van den Heuvel-Eibrink, Dirk Reinhardt, Karl Welte, Julia Skokowa   +7 more
doaj   +1 more source

NAMPT and NAPRT: Two Metabolic Enzymes With Key Roles in Inflammation

Frontiers in Oncology, 2020
Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT) are two intracellular enzymes that catalyze the first step in the biosynthesis of NAD from nicotinamide and nicotinic acid, respectively.
Valentina Audrito, Vincenzo Gianluca Messana, Silvia Deaglio   +2 more
doaj   +1 more source

Huangqi-Danshen decoction protects against cisplatin-induced acute kidney injury in mice

Frontiers in Pharmacology, 2023
Background: Acute kidney injury (AKI) induced by cisplatin remains a major impediment to the clinical application of cisplatin, necessitating urgent exploration for promising solutions.
Xinhui Liu, Liwen Gao, Xi Huang, Ruyu Deng, Shanshan Wu, Yu Peng, Jiandong Lu   +6 more
doaj   +1 more source

Synthesizing and salvaging NAD: lessons learned from Chlamydomonas reinhardtii.

PLoS Genetics, 2010
The essential coenzyme nicotinamide adenine dinucleotide (NAD+) plays important roles in metabolic reactions and cell regulation in all organisms. Bacteria, fungi, plants, and animals use different pathways to synthesize NAD+.
Huawen Lin, Alan L Kwan, Susan K Dutcher
doaj   +1 more source

PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma

Nature Communications, 2019
Mutations in the Protein Phosphatase PPM1D are oncogenic in certain cancers including diffuse intrinsic pontine glioma (DIPG). Here, the authors show that PPM1D mutations in DIPG induce the silencing of the nicotinic acid phosphoribosyltransferase gene ...
Nathan R. Fons, Ranjini K. Sundaram, Gregory A. Breuer, Sen Peng, Ryan L. McLean, Aravind N. Kalathil, Mark S. Schmidt, Diana M. Carvalho, Alan Mackay, Chris Jones, Ángel M. Carcaboso, Javad Nazarian, Michael E. Berens, Charles Brenner, Ranjit S. Bindra   +14 more
doaj   +1 more source

NAD+ metabolism controls inflammation during senescence

Molecular & Cellular Oncology, 2019
We have recently discovered that nicotinamide adenine dinucleotide metabolism controls the pro-inflammatory senescence-associated secretory phenotype during cellular senescence.
Timothy Nacarelli, Rugang Zhang
doaj   +1 more source