Results 41 to 50 of about 6,777 (132)

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, Volume 16, Issue 1, Page 52-67, January 2026.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Therapeutics: Rationales, Controversies, Clinical Experience

Current Drug Targets, 2013
Nicotinamide adenine dinucleotide (NAD+) biosynthesis from nicotinamide is used by mammalian cells to replenish their NAD+ stores and to avoid unwanted nicotinamide accumulation. Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), the key enzyme in this biosynthetic pathway, almost invariably leads to intracellular NAD ...
MONTECUCCO, FABRIZIO, CEA, MICHELE, Bauer I, SONCINI, DEBORA, CAFFA, IRENE, Lasigliè D, Nahimana A, UCCELLI, ANTONIO, BRUZZONE, SANTINA, NENCIONI, ALESSIO   +9 more
openaire   +3 more sources

Inhibition of Nicotinamide Phosphoribosyltransferase [PDF]

Journal of Biological Chemistry, 2010
Maria Pittelli, Laura Formentini, Giuseppe Faraco, Andrea Lapucci, Elena Rapizzi, Francesca Cialdai, Giovanni Romano, Gloriano Moneti, Flavio Moroni, Alberto Chiarugi   +9 more
openaire   +1 more source

Extracellular nicotinamide phosphoribosyltransferase: role in disease pathophysiology and as a biomarker. [PDF]

Front Immunol, 2023
Semerena E, Nencioni A, Masternak K.
europepmc   +1 more source

Nicotinamide Phosphoribosyltransferase Facilitates Post‐Stroke Angiogenesis [PDF]

CNS Neuroscience & Therapeutics, 2015
Pei, Wang, Yun-Feng, Guan, Wen-Lin, Li, Guo-Cai, Lu, Jian-Min, Liu, Chao-Yu, Miao   +5 more
openaire   +2 more sources

Nicotinamide phosphoribosyltransferase (NAMPT) [PDF]

Science-Business eXchange, 2012
openaire   +3 more sources

Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. [PDF]

Biochemistry, 2023
Ratia KM, Shen Z, Gordon-Blake J, Lee H, Laham MS, Krider IS, Christie N, Ackerman-Berrier M, Penton C, Knowles NG, Musku SR, Fu J, Velma GR, Xiong R, Thatcher GRJ.   +14 more
europepmc   +1 more source

Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis. [PDF]

Front Public Health, 2023
Sun X, Su L, Bu T, Zhang Y.
europepmc   +1 more source

Synthesis, Optimization, and Structure-Activity Relationships of Nicotinamide Phosphoribosyltransferase (NAMPT) Positive Allosteric Modulators (N-PAMs). [PDF]

J Med Chem, 2023
Shen Z, Ratia K, Krider I, Ackerman-Berrier M, Penton C, Musku SR, Gordon-Blake JM, Laham MS, Christie N, Ma N, Fu J, Xiong R, Courey JM, Velma GR, Thatcher GRJ.   +14 more
europepmc   +1 more source

Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) neutralization counteracts T cell immune evasion in breast cancer. [PDF]

J Immunother Cancer, 2023
Travelli C, Colombo G, Aliotta M, Fagiani F, Fava N, De Sanctis R, Grolla AA, Garcia JGN, Clemente N, Portararo P, Costanza M, Condorelli F, Colombo MP, Sangaletti S, Genazzani AA.   +14 more
europepmc   +1 more source