Results 101 to 110 of about 297,452 (281)
An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse. [PDF]
, 2018 Tobacco use disorder is the leading cause of disease and preventable death worldwide, but current medications that are based on pharmacodynamics have low efficacy.
George, Olivier +4 more
core +1 more source
Increasing phospholipid biomimicry governs water permeability in droplet interface bilayers
Droplet, EarlyView.Increasing phospholipid biomimicry in droplet interface bilayers alters how membranes respond to “membrane‐active molecules” such as cholesterol and niacin. This shows that membranes made using synthetic lipids can overestimate small‐molecule effects, highlighting the importance of using biomimetic lipid compositions to improve physiological relevance ...
Alejandro Forigua, Katherine S. Elvira
wiley +1 more source
MicroRNA Regulation of nAChR Expression and Nicotine-Dependent Behavior in C. elegans
Cell Reports, 2017 Summary: Chronic exposure to nicotine upregulates nicotinic acetylcholine receptors (nAChRs), and such upregulation is critical for the development of nicotine dependence in humans and animal models.
Manish Rauthan +6 more
doaj +1 more source
Drug Testing and Analysis, EarlyView.New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley +1 more source
Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle
Developmental Dynamics, EarlyView.Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell +3 more
wiley +1 more source
Neurofeedback for Binge‐Eating Disorder: Neurophysiological Outcome Predictors and Rapid Response
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Pioneer studies suggested the effectiveness of food‐specific electroencephalography (EEG) and real‐time functional near‐infrared spectroscopy (rtfNIRS) neurofeedback (NF) trainings in the treatment of binge‐eating disorder (BED). These trainings aim to improve participants' neurophysiological self‐regulation.
Ben Schreglmann +3 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li +12 more
wiley +1 more source
An update on nicotine replacement therapy
Journal of Oral Research and Review, 2019 Tobacco use is the single greatest preventable cause of death in the world. Most tobacco users want to quit but find it difficult to stop due to the addictiveness of nicotine. Interventions for tobacco cessation are important in enabling tobacco users to
K A Kamala, S Sankethguddad, S G Sujith
doaj +1 more source
Improvement of Peak Integration in Capillary Electrophoresis: Reference Data Set No. 1
ELECTROPHORESIS, EarlyView.ABSTRACT Capillary electrophoresis (CE) often provides superior separation of macromolecules such as monoclonal antibodies (mAbs), a major biopharmaceutical class, compared with liquid chromatography. However, electropherograms frequently exhibit complex baselines and peak shapes that are not reliably handled by integration algorithms designed for ...
Marlon Krompholz +14 more
wiley +1 more source
Drug and Alcohol Dependence ReportsIn the past few years, technological advancements enabled the development of novel electronic nicotine delivery systems (ENDS). Several empirical measures such as “nicotine flux” are being proposed to evaluate the abuse liability potential of these ...
Aditya R. Kolli +7 more
doaj +1 more source