Results 81 to 90 of about 159,313 (139)

The Proteome of African Spitting and Non‐Spitting Cobra Venoms and Cytotoxicity Against Pancreatic Cancer Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT African cobra (Naja spp.) venom contains toxins dominated by proteins and peptides with inter‐ and intra‐specific variations. There are several FDA‐approved drugs from snake venom toxins from other regions, including South America and Asia. Profiling the proteomes of medically important African cobra venoms from different locations will aid in
Benedict C. Offor, Beric Muller, Lesetja R. Motadi, Lizelle A. Piater   +3 more
wiley   +1 more source

Physiologically Based Pharmacokinetic (PBPK) Model to Predict the Magnitude of Drug–Drug Interaction Between Fezolinetant and CYP1A2 Inhibitors

The Journal of Clinical Pharmacology, EarlyView.
Abstract Fezolinetant is a non‐hormonal, selective neurokinin 3 receptor antagonist approved in multiple countries including the United States, in Europe, and in Asia for the treatment of moderate to severe vasomotor symptoms in menopausal women. Fezolinetant is primarily metabolized by CYP1A2 and was found to be a sensitive substrate for CYP1A2 ...
Mary P. Choules, Yukio Otsuka, Jace C. Nielsen, Megumi Iwai, Peter L. Bonate   +4 more
wiley   +1 more source

Physiologically Based Pharmacokinetic Modeling to Predict Nicotine Pharmacokinetics of Nicotine Pouches Under Naturalistic Use Conditions

The Journal of Clinical Pharmacology, EarlyView.
Abstract Adult users of traditional tobacco products like combustible cigarettes (CC) or moist smokeless tobacco (MST) products can reduce exposure to toxicants by switching to potentially less harmful alternatives such as tobacco‐free nicotine pouches (NP). Nicotine exposure assessment is an important consideration to determine the switching potential
Ali Salehi, Mohamadi A. Sarkar, Jennifer H. Smith, Ali A. Rostami   +3 more
wiley   +1 more source

Multi‐cycle high‐throughput growth media optimization using batch Bayesian optimization

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND The optimization of growth media is a crucial step in enhancing microbial growth and product formation in industrial bioprocesses. While Design of Experiments (DoE) is widely used for this purpose, it has inherent limitations, particularly in capturing complex interactions between media components and managing the high number of ...
Frédéric M. Lapierre, Pasquale Mattaliano, Dennis Raith, Mariela Castillo‐Cota, Jonas Bermeitinger, Robert Huber   +5 more
wiley   +1 more source

Genetically‐targeted control of the spinal cord and peripheral nervous system

Journal of Intelligent Medicine, EarlyView.
Application of genetically‐targeted stimulation for treating diseases or injuries outside the brain. Optogenetic and chemogenetic systems have been developed for dysfunction in the cochlea, spinal cord, dorsal root ganglia (DRGs), peripheral nerves, lower urinary tract, and enteric nervous system (ENS). Created with Biorender.com.
Anakaren Romero Lozano, Victoria Koptelova, Zoya Ahmad, Huiliang (Evan) Wang   +3 more
wiley   +1 more source

Early Division of the Paramedian Forehead Flap: A Systematic Review and Retrospective Analysis

The Laryngoscope, EarlyView.
Early division of the paramedian forehead flap pedicle may help alleviate emotional distress, functional deficit, and productivity cost associated with the reconstructive process. In the present cohort, flap division 16 days and earlier was feasible and safe in nonsmoking patients with partial thickness defects and limited use of cartilage grafting ...
Connie C. Ma, Clara Si, Feyisayo Adegboye, Jaclyn Lee, Ina Lee, Scott J. Stephan, Priyesh N. Patel, Shiayin F. Yang   +7 more
wiley   +1 more source

Non‐Tobacco Nicotine Use and Complications in Free Flap Repair in Head and Neck Cancer

The Laryngoscope, EarlyView.
Non‐tobacco nicotine use is associated with an increased risk of postoperative complications in HNC patients following free flap reconstruction. ABSTRACT Objective Assess associations between non‐tobacco nicotine usage and free flap repair complications in head and neck cancer (HNC) patients.
Asher C. Park, Larry Wang, Milan P. Fehrenbach, Oluwatobiloba Ayo‐Ajibola, Urjeet A. Patel, Sandeep Samant, Katelyn O. Stepan   +6 more
wiley   +1 more source

Responses of Consumers to the Mandatory Disclosure of Information: Evidence from Natural Experiments in Japanese Inter-brand Cigarette Demands [PDF]

I estimated inter-brand cigarette demands with nicotine, tar content and policy event information in Japan during 1950-84. The demand for all brands increased but the demand for plain (non-filter) brands decreased due to the dissemination ofgA Note about
Junmin Wan
core  

Malignant Transformation Rate of Oral Premalignant Disorders: A Large Database Analysis

The Laryngoscope, EarlyView.
ABSTRACT Objectives Oral leukoplakia (OL), oral lichen planus (OLP), and oral submucous fibrosis (OSF) are precancerous lesions known to progress to oral squamous cell carcinoma (OSCC). The transformation rates to OSCC are controversial and have been based on small, heterogeneous, single‐institution studies. We present the largest study to date looking
Andrew Meci, Neerav Goyal, David Goldenberg   +2 more
wiley   +1 more source

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, EarlyView.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source