Results 41 to 50 of about 138,340 (316)

Embedded Cholesterol in the Nicotinic Acetylcholine Receptor [PDF]

Biophysical Journal, 2008
The nicotinic acetylcholine receptor (nAChR) is a cation-selective channel central to both neuronal and muscular processes and is considered the prototype for ligand-gated ion channels, motivating a structural determination effort that spanned several decades [Unwin N (2005) Refined structure of the nicotinic acetylcholine receptor at 4 Å ...
Jérôme Hénin, Grace Brannigan, Richard J. Law, Michael L. Klein, Roderic G. Eckenhoff   +4 more
openaire   +4 more sources

Discoveries and future significance of research into amyloid-beta/α7-containing nicotinic acetylcholine receptor (nAChR) interactions

Pharmacological Research, 2023
Initiated by findings that Alzheimer’s disease is associated with a profound loss of cholinergic markers in human brain, decades of studies have examined the interactions between specific subtypes of nicotinic acetylcholine receptors and amyloid-β ...
Paul Whiteaker, Andrew A. George
doaj  

The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia. [PDF]

PLoS ONE, 2016
The development of alpha7 nicotinic acetylcholine receptor agonists is considered a promising approach for the treatment of cognitive symptoms in schizophrenia patients. In the present studies we characterized the novel agent, (2R)-N-(6-(1H-imidazol-1-yl)
Linda J Bristow, Amy E Easton, Yu-Wen Li, Digavalli V Sivarao, Regina Lidge, Kelli M Jones, Debra Post-Munson, Christopher Daly, Nicholas J Lodge, Lizbeth Gallagher, Thaddeus Molski, Richard Pieschl, Ping Chen, Adam Hendricson, Ryan Westphal, James Cook, Christiana Iwuagwu, Daniel Morgan, Yulia Benitex, Dalton King, John E Macor, Robert Zaczek, Richard Olson   +22 more
doaj   +1 more source

Diversity of vertebrate nicotinic acetylcholine receptors [PDF]

Neuropharmacology, 2009
Nicotinic acetylcholine receptors (nAChRs) are pentameric neurotransmitter receptors. They are members of the Cys-loop family of ligand-gated ion channels which also include ionotropic receptors for 5-hydroxytryptamine (5-HT), gamma-aminobutyric acid (GABA) and glycine.
Millar NS, Gotti C
openaire   +4 more sources

Signaling of nicotinic acetylcholine receptors in mononuclear phagocytes

Pharmacological Research, 2023
Nicotinic acetylcholine receptors are not only expressed by the nervous system and at the neuro-muscular junction but also by mononuclear phagocytes, which belong to the innate immune system.
Katrin Richter, Veronika Grau
doaj  

Functional characterisation of a nicotinic acetylcholine receptor alpha subunit from the brown dog tick, Rhipicephalus sanguineus [PDF]

, 2014
Open Access funded by Biotechnology and Biological Sciences Research Council Under a Creative Commons license This work was supported by a Biotechnology and Biological Sciences Research Council (UK) Industrial CASE studentship award (BBSSM200411428) to K.
Alan S. Bowman, Aljamali, Anatriello, Anderson, Andrew K. Jones, Baines, Ball, Bass, Bennett, Bertrand, Bissinger, Blagburn, Blake, Bowman, Breer, Buckingham, Buckingham, Chmelar, David B. Sattelle, Debra J. Woods, Dederer, Dederer, Dermauw, Erdmanis, Gao, Geng, George, Gray, Grbic, Halevi, Halevi, Hedges, Hermsen, Hosie, Hsu, Huang, Inokuma, Jeschke, Jeyaprakash, Jones, Jongejan, Kao, Karim, Kazuhiko Matsuda, Kristin Lees, Kumar, Lansdell, Lansdell, Lansdell, Lees, Lees, Liu, Lupu-Meiri, Marshall, Meinke, Miki Akamatsu, Miller, Mounsey, Nauen, Nene, Perry, Roma, Salgado, Simo, Sonenshine, Song, Tang, Taylor, Turberg, Watson, Woods, Yao, Zheng   +72 more
core   +3 more sources

Identification and Characterization of a G Protein-binding Cluster in α7 Nicotinic Acetylcholine Receptors*

Journal of Biological Chemistry, 2015
Background: α7 nicotinic acetylcholine receptors are ligand-gated ion channels that bind intracellular signaling proteins. Results: A mutation in the M3-M4 loop of the α7 nicotinic acetylcholine receptor abolishes Gαq activation of intracellular calcium ...
J. R. King, Jacob C. Nordman, Samuel P Bridges, Mingkuan Lin, N. Kabbani   +4 more
semanticscholar   +1 more source

Alpha7 nicotinic acetylcholine receptor signaling modulates ovine fetal brain astrocytes transcriptome in response to endotoxin [PDF]

Front. Immunol. 2019, 2018
Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of astrocytes. We hypothesized that agonism on alpha7 nicotinic acetylcholine receptor (alpha7nAChR) in fetal astrocytes
arxiv   +1 more source

Acetylcholine induces stem cell properties of gastric cancer cells of diffuse type

Tumor Biology, 2018
Gastric cancer is the third leading cause of cancer-related death worldwide, but the mechanisms of gastric carcinogenesis are not completely understood.
Phu Hung Nguyen, Yann Touchefeu, Tony Durand, Philippe Aubert, Emilie Duchalais, Stanislas Bruley des Varannes, Christine Varon, Michel Neunlist, Tamara Matysiak-Budnik   +8 more
doaj   +1 more source

Nicotine addiction : a review [PDF]

, 2013
Nicotine, the major psychoactive compound in tobacco, acts as a potent addictive drug in humans. The addictive nature of nicotine leads to more than 6 million deaths a year.
Di Giovanni, Giuseppe, Vella, Jacob
core   +1 more source