Results 81 to 90 of about 42,486 (297)
Cholinergic System Changes in Dopa‐Unresponsive Freezing of Gait in Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background Freezing of gait (FoG) is a debilitating mobility disturbance that becomes increasingly resistant to dopaminergic pharmacotherapies with advancing Parkinson's disease (PD). The pathophysiology underlying the response of FoG to dopaminergic treatment is poorly understood.
Kelvin L. Chou +6 more
wiley +1 more source
Nicotinic acetylcholine receptors mediate lung cancer growth
Frontiers in Physiology, 2013 Ion channels modulate ion flux across cell membranes, activate signal transduction pathways, and influence cellular transport – vital biological functions that are inexorably linked to cellular processes that go awry during carcinogenesis.
Ma. Reina eImprogo +3 more
doaj +1 more source
Boundary lipids of the nicotinic acetylcholine receptor: spontaneous partitioning via coarse-grained molecular dynamics simulation [PDF]
arXiv, 2018 Reconstituted nicotinic acetylcholine receptors (nAChRs) exhibit significant gain-of-function upon addition of cholesterol to reconstitution mixtures, and cholesterol affects organization of nAChRs within domain-forming membranes, but whether nAChR partitions to cholesterol-rich liquid-ordered ("raft" or $l_o$) domains or cholesterol-poor liquid ...
arxiv
Antidepressant-like Effects of Neuropeptide SF (NPSF) [PDF]
World Journal of Research and Review (WJRR) ISSN:2455-3956,
Volume-4, Issue-5, May 2017 Pages 26-30, 2020 Neuropeptide SF (NPSF) is a member of RFamide neuropeptides that play diverse roles in central nervous system. Little is know about the effects of NPSF on brain functions. Antidepressant-like effect of NPSF was studied in modified mice FST. NPSF showed the antidepressant-like effects by decreasing the immobility time and increasing the climbing and ...
arxiv
Regulation of Nicotinic Acetylcholine Receptor Assembly
Annals of the New York Academy of Sciences, 2003 Abstract: The four muscle‐type nicotinic acetylcholine receptor (AChR) subunits, α, β, γ, and δ, assemble into functional α2βγδ pentamers in the endoplasmic reticulum (ER) through a series of interdependent folding and oligomerization events. The first stable assembly intermediate is a trimer composed of α, β, and γ subunits.
Wanamaker, C, Christianson, J, Green, W
openaire +3 more sources
Light‐Activated Pharmacological Tools for Exploring the Cholinergic System
Medicinal Research Reviews, EarlyView.ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni +5 more
wiley +1 more source
Cell-surface translational dynamics of nicotinic acetylcholine receptors
Frontiers in Synaptic Neuroscience, 2014 Synapse efficacy heavily relies on the number of neurotransmitter receptors available at a given time. In addition to the equilibrium between the biosynthetic production, exocytic delivery and recycling of receptors on the one hand, and the endocytic ...
Francisco J Barrantes
doaj +1 more source
The Channel Capacity of Channelrhodopsin and Other Intensity-Driven Signal Transduction Receptors [PDF]
arXiv, 2018 Biological systems transduce signals from their surroundings through a myriad of pathways. In this paper, we describe signal transduction as a communication system: the signal transduction receptor acts as the receiver in this system, and can be modeled as a finite-state Markov chain with transition rates governed by the input signal.
arxiv
Cytoplasmic nanojunctions between lysosomes and sarcoplasmic reticulum are required for specific calcium signaling [PDF]
, 2014 We demonstrate how nanojunctions between lysosomes and sarcoplasmic reticulum (L-SR junctions) serve to couple lysosomal activation to regenerative, ryanodine receptor-mediated cellular calcium (Ca2+) waves. In pulmonary artery smooth muscle cells (PASMCs) nicotinic acid adenine dinucleotide phosphate (NAADP) may trigger increases in cytoplasmic Ca2 ...
arxiv +1 more source
Nicotinic Receptor Activity Alters Synaptic Plasticity
The Scientific World Journal, 2001 Studies using specific agonists, antagonists, and lesions have shown that nicotinic cholinergic systems participate in attention, learning, and memory[1,2].
John A. Dani
doaj +1 more source