Results 1 to 10 of about 97,079 (192)

Nicotinic acid induces antinociceptive and anti-inflammatory effects in different experimental models [PDF]

, 2012
Although in vitro studies have shown that nicotinic acid inhibits some aspects of the inflammatory response, a reduced number of in vivo studies have investigated this activity.
Bastos, Leandro Francisco S., Coelho, Márcio M., Ferreira, Raphael G., Ferreira, Wallace C., Godin, Adriana M., Merlo, Leonardo A., Nascimento, Elias B., Paiva, André Luiz L., Rocha, Leonardo Tadeu S.   +8 more
core   +1 more source

Arachidonic Acid as a Possible Negative Feedback Inhibitor of Nicotinic Acetylcholine Receptors on Neurons [PDF]

, 1995
Neuronal acetylcholine receptors, being highly permeable to calcium, are likely to regulate calcium-dependent events in neurons. Arachidonic acid is a membrane-permeant second messenger that can be released from membrane phospholipids by phospholipases ...
Berg, Darwin K., Blumenthal, Edward M, Huang, Bo, Vijayaraghavan, Sukumar   +3 more
core   +2 more sources

The distribution of charged amino acid residues and the Ca(2+) permeability of nicotinic acetylcholine receptors: a predictive model [PDF]

, 2017
Nicotinic acetylcholine receptors (nAChRs) are cation-selective ligand-gated ion channels exhibiting variable Ca(2+) permeability depending on their subunit composition.
Fucile, Sergio
core   +1 more source

Scientific Opinion on the safety and efficacy of niacin (nicotinic acid and nicotinamide) as a feed additive for all animal species based on a dossier submitted by Lonza Benelux BV [PDF]

, 2012
<p>The term ‘niacin’ is used as a generic description of nicotinic acid and nicotinamide with pyridine as the basic structure. Nicotinic acid and nicotinamide function mainly as precursors of the co-enzymes NAD and NADP.
AWT (Arbeitsgemeinschaft für Wirkstoffe in der Tierernährung e.V.), Baker, Chang, Chang, Copelin, Da Silva, EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), EFSA Panel on Food Additive and Nutrient Sources added to food (ANS), EFSA Panel on Food Additive and Nutrient Sources added to food (ANS), European Pharmacopeia (PhEur), European Pharmacopoeia (PhEur), Harmon, Harmon, Harms, Huff, Huff, Ivers, Johnson, Johnson, Knox, Leeson, Luce, Mason, Mason, McDowell, Niehof, Nilson, NRC (National Research Council), NRC (National Research Council), NRC (National Research Council), NRC (National Research Council), Oduho, Perlzweig, Real, Reddi, Shibata, Shibata, Shibata, Shibata, Wagner, Waldroup, Whittemore, Yen, Yen   +45 more
core   +2 more sources

Altered hippocampal plasticity by prenatal kynurenine administration, kynurenine-3-monoxygenase (KMO) deletion or galantamine [PDF]

, 2015
Glutamate receptors sensitive to N-methyl-d-aspartate (NMDA) are involved in embryonic brain development but their activity may be modulated by the kynurenine pathway of tryptophan metabolism which includes an agonist (quinolinic acid) and an antagonist (
Darlington, L.G., Forrest, C.M., Khalil, O.S., Mcnair, K., Pisar, M., Stone, T.W.   +5 more
core   +1 more source

Differential Contribution of Subunit Interfaces to α 9 α 10 Nicotinic Acetylcholine Receptor Function [PDF]

, 2017
Nicotinic acetylcholine receptors can be assembled from either homomeric or heteromeric pentameric subunit combinations. At the interface of the extracellular domains of adjacent subunits lies the acetylcholine binding site, composed of a principal ...
Boffi, Juan Carlos, Bouzat, Cecilia Beatriz, Collins, Toby, Corradi, Jeremias, Craig, Patricio Oliver, Elgoyhen, Ana Belen, Gill Thind, JasKiran K., Lipovsek, Maria Marcela, Marcovich, Irina, Millar, Neil S., Moglie, Marcelo Javier, Plazas, Paola Viviana   +11 more
core   +3 more sources

A New Method for the Determination of Nucleic Acid Using an Eu3+– nicotinic Acid Complex as a Resonance Light Scattering Probe [PDF]

, 2008
This study found that in Tris-HCl buffer, the resonance light scattering (RLS) intensity of the Eu3+-nicotinic acid system can be greatly enhanced by nucleic acids and the enhanced intensity is proportional to the concentration of nucleic acid in the ...
Collins, Jia, Jing-He Yang, Lin-Tong Wang, Liu, Liu, Meng Guo, Wei Xu, Wu, Wu, Xia Wu   +10 more
core   +2 more sources

Alzheimer’s Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts [PDF]

, 2019
Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol (Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid-ordered microdomains (raft domains), together with saturated ...
Antollini, Silvia Susana, Fabiani, Camila   +1 more
core   +1 more source

Ultrastructural Distribution of the 7 Nicotinic Acetylcholine Receptor Subunit in Rat Hippocampus [PDF]

, 2001
Acetylcholine (ACh) is an important neurotransmitter in the mammalian brain; it is implicated in arousal, learning, and other cognitive functions. Recent studies indicate that nicotinic receptors contribute to these cholinergic effects, in addition to ...
Alan Fine, Emanuele Sher, Heather A. Davies, Michael G. Stewart, Mick L. Errington, Paul Skehel, Ruth Fabian-Fine   +6 more
core   +1 more source

An expanding range of targets for kynurenine metabolites of tryptophan [PDF]

, 2013
The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that is not committed to protein synthesis and includes compounds active in the nervous and immune systems.
Darlington, L. Gail, Stone, Trevor W., Stoy, Nicholas   +2 more
core   +1 more source